BGC0000081: kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650
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Location: 1 - 135,420 nt. (total: 135,420 nt).
This entry is originally from NCBI GenBank JX679499.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000081
Short description kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Iterative type I)
Loci
JX679499.1
via Enzymatic assays
Compounds
  • kedarcidin
Species Streptoalloteichus sp. ATCC 53650 [taxonomy]
References
Chemical products information
kedarcidin Evidence:
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C53H60Cl1N3O16
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFV52099.1
 1834 - 2256 (-) hypothetical protein
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    • AFV52100.1
    		 2265 - 2420 (-) hypothetical protein
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      • AFV52101.1
      		 2617 - 2991 (-) hypothetical protein
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        • AFV52102.1
        		 3093 - 4097 (+) hypothetical protein
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          • AFV52103.1
          		 4291 - 5286 (+) putative O-methyltransferase
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            • AFV52104.1
            		 5630 - 5989 (+) hypothetical protein
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              • AFV52105.1
              		 6036 - 6518 (-) hypothetical protein
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                • AFV52106.1
                		 6515 - 7009 (-) putative flavin reductase
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                  • AFV52107.1
                  		 7003 - 7962 (-) putative monooxygenase
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                    • AFV52108.1
                    		 8093 - 8704 (+) putative TetR transcriptional regulator
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                      • AFV52109.1
                      		 8849 - 9790 (-) hypothetical protein
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                        • AFV52110.1
                        		 9953 - 10621 (+) hypothetical protein
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                          • AFV52111.1
                          		 10777 - 11385 (+) hypothetical protein
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                            • AFV52112.1
                            		 11382 - 11942 (+) hypothetical protein
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                              • AFV52113.1
                              		 12343 - 13569 (+) putative transporter
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                                • AFV52114.1
                                		 13566 - 14351 (+) hypothetical protein
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                                  • AFV52115.1
                                  		 14348 - 14944 (-) hypothetical protein DUF1470
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                                    • AFV52116.1
                                    		 15212 - 16102 (+) putative LysR transcriptional regulator
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                                      • AFV52117.1
                                      		 16189 - 16485 (+) hypothetical protein
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                                        • AFV52118.1
                                        		 16608 - 18056 (+) putative GntR transcriptional regulator/aminotransferase
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                                          • AFV52119.1
                                          		 18116 - 19228 (-) phenylalanine aminotransferase
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                                            • AFV52120.1
                                            		 19255 - 20298 (-) DAHP synthase
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                                              • AFV52121.1
                                              		 20316 - 20546 (-) chorismate mutase
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                                                • AFV52122.1
                                                		 20642 - 21265 (-) ADC synthase II
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                                                  • AFV52123.1
                                                  		 21246 - 22769 (-) ADC synthase I
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                                                    • AFV52124.1
                                                    		 22766 - 23443 (-) ADIC dehydrogenase
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                                                      • AFV52125.1
                                                      		 23714 - 23896 (+) 4-oxalocrotonate tatuomerase
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                                                        • AFV52126.1
                                                        		 23933 - 24316 (+) chorismate mutase-like protein
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                                                          • AFV52127.1
                                                          		 24778 - 25929 (+) peptidase
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                                                            • AFV52128.1
                                                            		 26002 - 26571 (-) TetR-like transcriptional regulator
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                                                              • AFV52129.1
                                                              		 26729 - 27571 (+) epoxide hydrolase-like protein
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                                                                • AFV52130.1
                                                                		 27640 - 28845 (-) hypothetical protein DUF297
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                                                                  • AFV52131.1
                                                                  		 29457 - 30257 (-) hypothetical protein
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                                                                    • AFV52132.1
                                                                    		 30348 - 31352 (-) hypothetical protein
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                                                                      • AFV52133.1
                                                                      		 31374 - 32036 (-) hypothetical protein
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                                                                        • AFV52134.1
                                                                        		 32015 - 32560 (-) hypothetical protein
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                                                                          • AFV52135.1
                                                                          		 32557 - 34194 (-) putative ketoreductase
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                                                                            • AFV52136.1
                                                                            		 34191 - 34760 (-) hypothetical protein
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                                                                              • AFV52137.1
                                                                              		 35246 - 36022 (+) AraC-like transcriptional regulator
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                                                                                • AFV52138.1
                                                                                		 36055 - 37395 (-) P450 monooxygenase
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                                                                                  • AFV52139.1
                                                                                  		 37392 - 37760 (-) hypothetical protein
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                                                                                    • AFV52140.1
                                                                                    		 37757 - 38809 (-) hypothetical protein
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                                                                                      • AFV52141.1
                                                                                      		 38814 - 40760 (-) hypothetical protein
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                                                                                        • AFV52142.1
                                                                                        		 40757 - 41740 (-) hypothetical protein
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                                                                                          • AFV52143.1
                                                                                          		 41806 - 42831 (-) hypothetical protein
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                                                                                            • AFV52144.1
                                                                                            		 42875 - 43834 (-) hypothetical protein
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                                                                                              • AFV52145.1
                                                                                              		 44355 - 50111 (+) polyketide synthase
                                                                                              • Scaffold biosynthesis
                                                                                              • Heterologous expression Other in vivo study
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                                                                                              • AFV52146.1
                                                                                              		 50113 - 50556 (+) hotdog fold thioesterase
                                                                                              • Scaffold biosynthesis
                                                                                              • Heterologous expression Other in vivo study
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                                                                                              • AFV52147.1
                                                                                              		 50553 - 51044 (+) flavin reductase
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                                                                                                • AFV52148.1
                                                                                                		 51325 - 52497 (+) putative enoyl reductase
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                                                                                                  • AFV52149.1
                                                                                                  		 52521 - 52943 (+) hypothetical protein
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                                                                                                    • AFV52150.1
                                                                                                    		 52933 - 54324 (+) FAD dependent monooxygenase
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                                                                                                      • AFV52151.1
                                                                                                      		 54373 - 55599 (-) P450 monooxygenase
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                                                                                                        • AFV52152.1
                                                                                                        		 55633 - 56787 (-) epoxide hydrolase
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                                                                                                          • AFV52153.1
                                                                                                          		 57336 - 58055 (+) hypothetical protein
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                                                                                                            • AFV52154.1
                                                                                                            		 58182 - 60449 (+) efflux pump
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                                                                                                              • AFV52155.1
                                                                                                              		 60497 - 61870 (-) NDP-hexose 2,3-dehydratase
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                                                                                                                • AFV52156.1
                                                                                                                		 61867 - 63408 (-) aryl-ACP hydroxylase
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                                                                                                                  • AFV52157.1
                                                                                                                  		 63643 - 64644 (+) O-methyltransferase
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                                                                                                                    • AFV52158.1
                                                                                                                    		 64685 - 65833 (+) sugar aminotransferase
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                                                                                                                      • AFV52159.1
                                                                                                                      		 65833 - 66579 (+) N-methyltransferase
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                                                                                                                        • AFV52160.1
                                                                                                                        		 66576 - 67307 (+) N-methyltransferase
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                                                                                                                          • AFV52161.1
                                                                                                                          		 67596 - 68879 (+) glycosyltransferase
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                                                                                                                            • AFV52162.1
                                                                                                                            		 69115 - 72378 (+) transcriptional regulator
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                                                                                                                              • AFV52163.1
                                                                                                                              		 72974 - 74854 (+) radical SAM C-methyltransferase
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                                                                                                                                • AFV52164.1
                                                                                                                                		 74851 - 76125 (+) acyl-CoA N-acyltransferase
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                                                                                                                                  • AFV52165.1
                                                                                                                                  		 76141 - 77391 (+) glycosyltransferase
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                                                                                                                                    • AFV52166.1
                                                                                                                                    		 77513 - 77731 (+) hypothetical protein
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                                                                                                                                      • AFV52167.1
                                                                                                                                      		 77966 - 79066 (-) monooxygenase
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                                                                                                                                        • AFV52168.1
                                                                                                                                        		 79063 - 80046 (-) enoyl reductase
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                                                                                                                                          • AFV52169.1
                                                                                                                                          		 80055 - 81203 (-) enoyl reductase
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                                                                                                                                            • AFV52170.1
                                                                                                                                            		 81336 - 82526 (+) acyltransferase
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                                                                                                                                              • AFV52171.1
                                                                                                                                              		 82535 - 83755 (+) CoA transferase
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                                                                                                                                                • AFV52172.1
                                                                                                                                                		 83841 - 84581 (+) ketoreductase
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                                                                                                                                                  • AFV52173.1
                                                                                                                                                  		 84578 - 85033 (+) dehydratase
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                                                                                                                                                    • AFV52174.1
                                                                                                                                                    		 85023 - 85505 (+) dehydratase
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                                                                                                                                                      • AFV52175.1
                                                                                                                                                      		 85567 - 85800 (+) acyl-carrier protein
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                                                                                                                                                        • AFV52176.1
                                                                                                                                                        		 85804 - 87009 (+) ketosynthase
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                                                                                                                                                          • AFV52177.1
                                                                                                                                                          		 87006 - 88064 (+) ketosynthase
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                                                                                                                                                            • AFV52178.1
                                                                                                                                                            		 88064 - 89188 (+) ketosynthase
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                                                                                                                                                              • AFV52179.1
                                                                                                                                                              		 89185 - 90054 (+) ketosynthase
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                                                                                                                                                                • AFV52180.1
                                                                                                                                                                		 90047 - 90841 (+) hypothetical protein
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                                                                                                                                                                  • AFV52181.1
                                                                                                                                                                  		 90838 - 91758 (+) thioesterase
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                                                                                                                                                                    • AFV52182.1
                                                                                                                                                                    		 91755 - 92390 (+) isomerase
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                                                                                                                                                                      • AFV52183.1
                                                                                                                                                                      		 92506 - 93243 (+) aldolase
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                                                                                                                                                                        • AFV52184.1
                                                                                                                                                                        		 93277 - 96402 (+) acyl-CoA synthetase/P450 monooxygenase
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                                                                                                                                                                          • AFV52185.1
                                                                                                                                                                          		 96406 - 97383 (+) NDP-hexose oxidoreductase
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                                                                                                                                                                            • AFV52186.1
                                                                                                                                                                            		 97727 - 99007 (-) C-methyltransferase
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                                                                                                                                                                              • AFV52187.1
                                                                                                                                                                              		 99007 - 100665 (-) acyl-CoA synthetase
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                                                                                                                                                                                • AFV52188.1
                                                                                                                                                                                		 100944 - 101381 (-) kedarcidin apoprotein
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                                                                                                                                                                                  • AFV52189.1
                                                                                                                                                                                  		 101584 - 103266 (-) efflux pump
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                                                                                                                                                                                    • AFV52190.1
                                                                                                                                                                                    		 103443 - 105059 (-) 4-Methylideneimidazole-5-one (MIO)-containing aminomutases
                                                                                                                                                                                    • Tailoring
                                                                                                                                                                                    • Activity assay
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                                                                                                                                                                                    • AFV52191.1
                                                                                                                                                                                    		 105061 - 108576 (-) NRPS adenylation domain
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                                                                                                                                                                                      • AFV52192.1
                                                                                                                                                                                      		 108573 - 109928 (-) NRPS condensation domain
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                                                                                                                                                                                        • AFV52193.1
                                                                                                                                                                                        		 110231 - 111721 (+) enoyl reductase
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                                                                                                                                                                                          • AFV52194.1
                                                                                                                                                                                          		 111718 - 112884 (+) enoyl reductase
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                                                                                                                                                                                            • AFV52195.1
                                                                                                                                                                                            		 112881 - 114341 (+) acyl-CoA synthetase
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                                                                                                                                                                                              • AFV52196.1
                                                                                                                                                                                              		 114343 - 114618 (+) acyl-carrier protein
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                                                                                                                                                                                                • AFV52197.1
                                                                                                                                                                                                		 114615 - 115505 (+) hypothetical protein
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                                                                                                                                                                                                  • AFV52198.1
                                                                                                                                                                                                  		 115507 - 116247 (+) dihydropicolinate reductase
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                                                                                                                                                                                                    • AFV52199.1
                                                                                                                                                                                                    		 116244 - 118142 (+) acyl-ACP synthetase
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                                                                                                                                                                                                      • AFV52200.1
                                                                                                                                                                                                      		 118139 - 123547 (+) polyketide synthase module
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                                                                                                                                                                                                        • AFV52201.1
                                                                                                                                                                                                        		 123544 - 124440 (+) enoyl reductase
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                                                                                                                                                                                                          • AFV52202.1
                                                                                                                                                                                                          		 124437 - 124712 (+) acyl-carrier protein
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                                                                                                                                                                                                            • AFV52203.1
                                                                                                                                                                                                            		 124709 - 125911 (+) enoyl reductase
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                                                                                                                                                                                                              • AFV52204.1
                                                                                                                                                                                                              		 125908 - 126975 (+) hypothetical protein
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                                                                                                                                                                                                                • AFV52205.1
                                                                                                                                                                                                                		 126972 - 127715 (+) thioesterase
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                                                                                                                                                                                                                  • AFV52206.1
                                                                                                                                                                                                                  		 127729 - 128277 (+) hypothetical protein
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                                                                                                                                                                                                                    • AFV52207.1
                                                                                                                                                                                                                    		 128252 - 129478 (+) P450 monooxygenase
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                                                                                                                                                                                                                      • AFV52208.1
                                                                                                                                                                                                                      		 129934 - 130710 (+) transcriptional regulator
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                                                                                                                                                                                                                        • AFV52209.1
                                                                                                                                                                                                                        		 130765 - 131034 (-) NRPS peptidyl-carrier protein
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                                                                                                                                                                                                                          • AFV52210.1
                                                                                                                                                                                                                          		 131302 - 132777 (+) aryl-ACP halogenase
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                                                                                                                                                                                                                            • AFV52211.1
                                                                                                                                                                                                                            		 132774 - 133772 (+) NDP-hexose oxidoreductase
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                                                                                                                                                                                                                              • AFV52212.1
                                                                                                                                                                                                                              		 133780 - 134376 (+) NDP-hexose epimerase
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                                                                                                                                                                                                                                • AFV52213.1
                                                                                                                                                                                                                                		 134395 - 134829 (-) hypothetical protein
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                                                                                                                                                                                                                                  Biosynthesis information

                                                                                                                                                                                                                                  Biosynthetic modules

                                                                                                                                                                                                                                  Name
                                                                                                                                                                                                                                  Unk01
                                                                                                                                                                                                                                  Type
                                                                                                                                                                                                                                  nrps-type1
                                                                                                                                                                                                                                  Genes
                                                                                                                                                                                                                                  AFV52191.1
                                                                                                                                                                                                                                  Substrates
                                                                                                                                                                                                                                  R-aza-beta-tyrosine (evidence: )
                                                                                                                                                                                                                                  Integrated Monomers
                                                                                                                                                                                                                                  Domains
                                                                                                                                                                                                                                  adenylation
                                                                                                                                                                                                                                  Annotation changelog

                                                                                                                                                                                                                                  Entry version: 4

                                                                                                                                                                                                                                  Date
                                                                                                                                                                                                                                  Changes
                                                                                                                                                                                                                                  Submitters
                                                                                                                                                                                                                                  Reviewers
                                                                                                                                                                                                                                  2022-10-07
                                                                                                                                                                                                                                  Update chemical activity to schema version 2.11
                                                                                                                                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                                                                                                                  Entry version: 3

                                                                                                                                                                                                                                  Date
                                                                                                                                                                                                                                  Changes
                                                                                                                                                                                                                                  Submitters
                                                                                                                                                                                                                                  Reviewers
                                                                                                                                                                                                                                  2022-09-15
                                                                                                                                                                                                                                  Corrected gene identifiers
                                                                                                                                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                                                                                                  2022-09-15
                                                                                                                                                                                                                                  Added NRP substrate specificities
                                                                                                                                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                                                                                                  2022-09-15
                                                                                                                                                                                                                                  Fixed biosynthetic classes
                                                                                                                                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                                                                                                                  Entry version: 2

                                                                                                                                                                                                                                  Date
                                                                                                                                                                                                                                  Changes
                                                                                                                                                                                                                                  Submitters
                                                                                                                                                                                                                                  Reviewers
                                                                                                                                                                                                                                  2019-10-16
                                                                                                                                                                                                                                  Migrated from v1.4
                                                                                                                                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                                                                                                                  Entry version: 1

                                                                                                                                                                                                                                  Date
                                                                                                                                                                                                                                  Changes
                                                                                                                                                                                                                                  Submitters
                                                                                                                                                                                                                                  Reviewers
                                                                                                                                                                                                                                  2015-06-12
                                                                                                                                                                                                                                  Submitted
                                                                                                                                                                                                                                  • (ID: E2T2HCM4X7QXVS4LL4JVBPPK)
                                                                                                                                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                                                                                                  Detailed domain annotation
                                                                                                                                                                                                                                  Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                                                                                                                                                                                                  A domain glossary is available here, and an explanation of the visualisation is available here.
                                                                                                                                                                                                                                  Selected features only
                                                                                                                                                                                                                                  Show module domains
                                                                                                                                                                                                                                  Similar known gene clusters from MIBiG 4.0
                                                                                                                                                                                                                                  Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                                                                                                                                                                                                  Click on reference genes to show details of similarities to genes within the current region.
                                                                                                                                                                                                                                  Click on an accession to open that entry in the MiBIG database.