Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000081.1:
Cluster 1Polyketide1135420

BGC0000081, kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: kedarcidin
PubChem ID: 6477354
SMILES string: Copy to clipboard
Molecular formula: C53H60ClN3O16
Average molecular mass: 1030.518 Da
Molecular activity: Antibacterial, Cytotoxic
Molecular target: DNA

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Enediyine (cyclic)
Polyketide synthase subclass:
Iterative type I / Enediyne type I
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
KEDE
Iterative PKS subtype:
Partially reducing
Number of iterations:
7
Other
Thioesterase type:
Type II
Release / cyclization type:
Hydrolysis

Gene cluster description

kedarcidin (BGC0000081). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank JX679499, positions 29457-134376. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Xiaohui Yan (The Scripps Research Institute)

Literature references

1. Lohman JR et al. (2013) Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics. Mol Biosyst 9(3):478-91. doi: 10.1039/c3mb25523a. Epub 2013 Jan 29.
2. Huang SX et al. (2013) A new member of the 4-methylideneimidazole-5-one-containing aminomutase family from the enediyne kedarcidin biosynthetic pathway. Proc Natl Acad Sci U S A 110(20):8069-74. doi:
3. Horsman GP et al. (2013) Predictive model for epoxide hydrolase-generated stereochemistry in the biosynthesis of nine-membered enediyne antitumor antibiotics. Biochemistry 52(31):5217-24. doi: 10.1021/bi400572a. Epub 2013 Jul