BGC0000081: kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650
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Location: 1 - 135,420 nt. (total: 135,420 nt).
This entry is originally from NCBI GenBank JX679499.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000081
Short description kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Enediyine)
Loci NCBI GenBank: JX679499.1
Compounds
  • kedarcidin
Species Streptoalloteichus sp. ATCC 53650 [taxonomy]
References
Chemical products information
kedarcidin
Copy SMILES
C53H60Cl1N3O16
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFV52099.1
 1834 - 2256 (-) hypothetical protein
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  • AFV52100.1
 2265 - 2420 (-) hypothetical protein
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  • AFV52101.1
 2617 - 2991 (-) hypothetical protein
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  • AFV52102.1
 3093 - 4097 (+) hypothetical protein
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  • AFV52103.1
 4291 - 5286 (+) putative O-methyltransferase
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  • AFV52104.1
 5630 - 5989 (+) hypothetical protein
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  • AFV52105.1
 6036 - 6518 (-) hypothetical protein
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  • AFV52106.1
 6515 - 7009 (-) putative flavin reductase
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  • AFV52107.1
 7003 - 7962 (-) putative monooxygenase
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  • AFV52108.1
 8093 - 8704 (+) putative TetR transcriptional regulator
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  • AFV52109.1
 8849 - 9790 (-) hypothetical protein
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  • AFV52110.1
 9953 - 10621 (+) hypothetical protein
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  • AFV52111.1
 10777 - 11385 (+) hypothetical protein
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  • AFV52112.1
 11382 - 11942 (+) hypothetical protein
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  • AFV52113.1
 12343 - 13569 (+) putative transporter
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  • AFV52114.1
 13566 - 14351 (+) hypothetical protein
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  • AFV52115.1
 14348 - 14944 (-) hypothetical protein DUF1470
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  • AFV52116.1
 15212 - 16102 (+) putative LysR transcriptional regulator
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  • AFV52117.1
 16189 - 16485 (+) hypothetical protein
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  • AFV52118.1
 16608 - 18056 (+) putative GntR transcriptional regulator/aminotransferase
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  • AFV52119.1
 18116 - 19228 (-) phenylalanine aminotransferase
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  • AFV52120.1
 19255 - 20298 (-) DAHP synthase
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  • AFV52121.1
 20316 - 20546 (-) chorismate mutase
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  • AFV52122.1
 20642 - 21265 (-) ADC synthase II
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  • AFV52123.1
 21246 - 22769 (-) ADC synthase I
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  • AFV52124.1
 22766 - 23443 (-) ADIC dehydrogenase
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  • AFV52125.1
 23714 - 23896 (+) 4-oxalocrotonate tatuomerase
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  • AFV52126.1
 23933 - 24316 (+) chorismate mutase-like protein
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  • AFV52127.1
 24778 - 25929 (+) peptidase
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  • AFV52128.1
 26002 - 26571 (-) TetR-like transcriptional regulator
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  • AFV52129.1
 26729 - 27571 (+) epoxide hydrolase-like protein
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  • AFV52130.1
 27640 - 28845 (-) hypothetical protein DUF297
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  • AFV52131.1
 29457 - 30257 (-) hypothetical protein
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  • AFV52132.1
 30348 - 31352 (-) hypothetical protein
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  • AFV52133.1
 31374 - 32036 (-) hypothetical protein
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  • AFV52134.1
 32015 - 32560 (-) hypothetical protein
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  • AFV52135.1
 32557 - 34194 (-) putative ketoreductase
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  • AFV52136.1
 34191 - 34760 (-) hypothetical protein
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  • AFV52137.1
 35246 - 36022 (+) AraC-like transcriptional regulator
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  • AFV52138.1
 36055 - 37395 (-) P450 monooxygenase
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  • AFV52139.1
 37392 - 37760 (-) hypothetical protein
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  • AFV52140.1
 37757 - 38809 (-) hypothetical protein
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  • AFV52141.1
 38814 - 40760 (-) hypothetical protein
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  • AFV52142.1
 40757 - 41740 (-) hypothetical protein
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  • AFV52143.1
 41806 - 42831 (-) hypothetical protein
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  • AFV52144.1
 42875 - 43834 (-) hypothetical protein
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  • AFV52145.1
 44355 - 50111 (+) polyketide synthase
  • Scaffold biosynthesis
Heterologous expression
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  • AFV52146.1
 50113 - 50556 (+) hotdog fold thioesterase
  • Scaffold biosynthesis
Heterologous expression
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  • AFV52147.1
 50553 - 51044 (+) flavin reductase
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  • AFV52148.1
 51325 - 52497 (+) putative enoyl reductase
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  • AFV52149.1
 52521 - 52943 (+) hypothetical protein
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  • AFV52150.1
 52933 - 54324 (+) FAD dependent monooxygenase
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  • AFV52151.1
 54373 - 55599 (-) P450 monooxygenase
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  • AFV52152.1
 55633 - 56787 (-) epoxide hydrolase
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  • AFV52153.1
 57336 - 58055 (+) hypothetical protein
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  • AFV52154.1
 58182 - 60449 (+) efflux pump
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  • AFV52155.1
 60497 - 61870 (-) NDP-hexose 2,3-dehydratase
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  • AFV52156.1
 61867 - 63408 (-) aryl-ACP hydroxylase
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  • AFV52157.1
 63643 - 64644 (+) O-methyltransferase
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  • AFV52158.1
 64685 - 65833 (+) sugar aminotransferase
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  • AFV52159.1
 65833 - 66579 (+) N-methyltransferase
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  • AFV52160.1
 66576 - 67307 (+) N-methyltransferase
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  • AFV52161.1
 67596 - 68879 (+) glycosyltransferase
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  • AFV52162.1
 69115 - 72378 (+) transcriptional regulator
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  • AFV52163.1
 72974 - 74854 (+) radical SAM C-methyltransferase
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  • AFV52164.1
 74851 - 76125 (+) acyl-CoA N-acyltransferase
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  • AFV52165.1
 76141 - 77391 (+) glycosyltransferase
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  • AFV52166.1
 77513 - 77731 (+) hypothetical protein
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  • AFV52167.1
 77966 - 79066 (-) monooxygenase
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  • AFV52168.1
 79063 - 80046 (-) enoyl reductase
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  • AFV52169.1
 80055 - 81203 (-) enoyl reductase
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  • AFV52170.1
 81336 - 82526 (+) acyltransferase
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  • AFV52171.1
 82535 - 83755 (+) CoA transferase
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  • AFV52172.1
 83841 - 84581 (+) ketoreductase
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  • AFV52173.1
 84578 - 85033 (+) dehydratase
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  • AFV52174.1
 85023 - 85505 (+) dehydratase
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  • AFV52175.1
 85567 - 85800 (+) acyl-carrier protein
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  • AFV52176.1
 85804 - 87009 (+) ketosynthase
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  • AFV52177.1
 87006 - 88064 (+) ketosynthase
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  • AFV52178.1
 88064 - 89188 (+) ketosynthase
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  • AFV52179.1
 89185 - 90054 (+) ketosynthase
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  • AFV52180.1
 90047 - 90841 (+) hypothetical protein
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  • AFV52181.1
 90838 - 91758 (+) thioesterase
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  • AFV52182.1
 91755 - 92390 (+) isomerase
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  • AFV52183.1
 92506 - 93243 (+) aldolase
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  • AFV52184.1
 93277 - 96402 (+) acyl-CoA synthetase/P450 monooxygenase
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  • AFV52185.1
 96406 - 97383 (+) NDP-hexose oxidoreductase
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  • AFV52186.1
 97727 - 99007 (-) C-methyltransferase
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  • AFV52187.1
 99007 - 100665 (-) acyl-CoA synthetase
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  • AFV52188.1
 100944 - 101381 (-) kedarcidin apoprotein
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  • AFV52189.1
 101584 - 103266 (-) efflux pump
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  • AFV52190.1
 103443 - 105059 (-) 4-Methylideneimidazole-5-one (MIO)-containing aminomutases
  • Tailoring (Unknown)
Activity assay
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  • AFV52191.1
 105061 - 108576 (-) NRPS adenylation domain
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  • AFV52192.1
 108573 - 109928 (-) NRPS condensation domain
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  • AFV52193.1
 110231 - 111721 (+) enoyl reductase
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  • AFV52194.1
 111718 - 112884 (+) enoyl reductase
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  • AFV52195.1
 112881 - 114341 (+) acyl-CoA synthetase
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  • AFV52196.1
 114343 - 114618 (+) acyl-carrier protein
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  • AFV52197.1
 114615 - 115505 (+) hypothetical protein
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  • AFV52198.1
 115507 - 116247 (+) dihydropicolinate reductase
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  • AFV52199.1
 116244 - 118142 (+) acyl-ACP synthetase
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  • AFV52200.1
 118139 - 123547 (+) polyketide synthase module
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  • AFV52201.1
 123544 - 124440 (+) enoyl reductase
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  • AFV52202.1
 124437 - 124712 (+) acyl-carrier protein
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  • AFV52203.1
 124709 - 125911 (+) enoyl reductase
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  • AFV52204.1
 125908 - 126975 (+) hypothetical protein
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  • AFV52205.1
 126972 - 127715 (+) thioesterase
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  • AFV52206.1
 127729 - 128277 (+) hypothetical protein
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  • AFV52207.1
 128252 - 129478 (+) P450 monooxygenase
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  • AFV52208.1
 129934 - 130710 (+) transcriptional regulator
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  • AFV52209.1
 130765 - 131034 (-) NRPS peptidyl-carrier protein
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  • AFV52210.1
 131302 - 132777 (+) aryl-ACP halogenase
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  • AFV52211.1
 132774 - 133772 (+) NDP-hexose oxidoreductase
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  • AFV52212.1
 133780 - 134376 (+) NDP-hexose epimerase
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  • AFV52213.1
 134395 - 134829 (-) hypothetical protein
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Polyketide-specific information
Subclass Enediyine
Starter unit Acetyl-CoA
Cyclic? yes
Release type
  • Hydrolysis
Polyketide-synthases
Genes Properties Modules
AFV52145.1
+
AFV52146.1 		Synthase subclass: Iterative type I/Enediyne type I
Thioesterases:
  • AFV52146.1 (Type II)
Iterative PKS type: Partially reducing, Unknown
Iteration counts: 7
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
AFV52191.1
Module ?
Specificity: R-aza-beta-tyrosine
Evidence for specificity:
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: E2T2HCM4X7QXVS4LL4JVBPPK, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected gene identifiers
  • Added NRP substrate specificities
  • Fixed biosynthetic classes
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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