BGC0000084: laidlomycin biosynthetic gene cluster from Streptomyces sp. CS684
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Location: 1 - 102,840 nt. (total: 102,840 nt).
This entry is originally from NCBI GenBank JQ793783.1.

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core biosynthetic genes
additional biosynthetic genes
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resistance
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General
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NRPS/PKS domains
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General information about the BGC
MIBiG accession BGC0000084
Short description laidlomycin biosynthetic gene cluster from Streptomyces sp. CS684
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: JQ793783.1
Compounds
  • laidlomycin
Species Streptomyces sp. CS684 [taxonomy]
References
Chemical products information
laidlomycin
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C37H62O12
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFL48545.1
 114 - 698 (+) hypothetical protein
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  • AFL48544.1
 1095 - 2804 (-) putative cytochrome c oxidase
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  • AFL48547.1
 3136 - 5487 (-) putative histidine kinase sensor
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  • AFL48546.1
 5867 - 8620 (+) putative magnesium/manganese-dependent protein phosphatase
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  • AFL48521.1
  • ladA
 9021 - 11429 (-) beta-ketosynthase
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  • AFL48522.1
  • ladBI
 11522 - 12424 (-) Epoxide hydrolase
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  • AFL48523.1
  • ladT
 12705 - 14240 (+) laidlomycin efflux protein
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  • AFL48548.1
  • ladRI
 14254 - 14829 (+) Transcription regulator (TetR family)
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  • AFL48524.1
  • ladD
 15060 - 15848 (-) Thioesterase
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  • AFL48525.1
  • ladSI
 16118 - 23410 (+) laidlomycin polyketide synthase (loading module and module 1)
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  • AFL48526.1
  • ladSII
 23417 - 29932 (+) laidlomycin polyketide synthase (module 2)
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  • AFL48527.1
  • ladSIII
 29985 - 41879 (+) laidlomycin polyketide synthase (module 3 and module 4)
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  • AFL48529.1
  • ladSIV
 41965 - 53637 (+) laidlomycin polyketide synthase (module 5 and module 6)
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  • AFL48528.1
  • ladSV
 53687 - 65374 (+) laidlomycin polyketide synthase (module 7 and module 8)
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  • AFL48520.1
  • ladSVI
 65392 - 70269 (+) laidlomycin polyketide synthase (module 9)
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  • AFL48550.1
  • ladBII
 70432 - 71877 (-) epoxide hydrolase
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  • AFL48530.1
  • ladCI
 71874 - 72311 (-) epoxidase
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  • AFL48531.1
  • ladCII
 72336 - 72770 (-) Epoxidase
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  • AFL48532.1
  • ladSVIII
 72767 - 83737 (-) laidlomycin polyketide synthase (module 11 and module 12)
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  • AFL48533.1
  • ladSVII
 83802 - 88688 (-) laidlomycin polyketide synthase (module 10)
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  • AFL48549.1
  • ladE
 88923 - 90233 (+) cytochrome P450 hydroxylase
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  • AFL48534.1
  • ladRII
 90315 - 91100 (-) transcription regulator (SARP family)
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  • AFL48535.1
  • ladF
 91872 - 92300 (+) hypothetical protein
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  • AFL48536.1
  • ladG
 92698 - 93945 (-) putative acyl transferase
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  • AFL48537.1
 94049 - 94714 (-) putative membrane protein
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  • AFL48538.1
 95176 - 96501 (+) putative major facilitator superfamily transporter
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  • AFL48539.1
 96627 - 98033 (+) putative succinic semialdehyde dehydrogenase
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  • AFL48540.1
 98254 - 99468 (+) hypothetical protein
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  • AFL48541.1
 99495 - 99962 (-) hypothetical protein
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  • AFL48542.1
 100172 - 101158 (-) putative dihydroxyacetone kinase
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  • AFL48543.1
 101360 - 102391 (+) putative peptide transporter (ATP-binding subunit)
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  • AFL48551.1
 102589 - >102840 (+) peptide transporter (peptide-binding subunit)
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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