BGC0000084 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000084 (Streptomyces sp. CS684)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	102,840	High	laidlomycin	PKS

BGC0000084 - Region 1 - T1PKS

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Location: 1 - 102,840 nt. (total: 102,840 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 102,841
Label		BGC0000084

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

AFL48539.1: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

ladBII: monooxygenase FAD-binding

smcogs: SMCOG1246: monooxygenase FAD-binding

ladE: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

ladSVIII: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: acylase

ladSVI: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: dehalogenase esterase

ladBI: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

ladD: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: ligase synthase

ladA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ladG: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

ladSI: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

ladSII: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

ladSIII: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

ladSIV: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ladSV: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ladSVII: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000084.5	1.00	PKS	laidlomycin	Streptomyces sp. CS684
BGC0001273.3	0.77	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001670.5	0.76	PKS	monensin	Streptomyces cinnamonensis
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0000100.5	0.67	PKS	monensin	Streptomyces cinnamonensis
BGC0002192.3	0.67	PKS	FR901512	fungal sp. No.14919
BGC0002154.2	0.67	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000084.5	1.00	PKS	laidlomycin	Streptomyces sp. CS684
BGC0001273.3	0.77	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001670.5	0.76	PKS	monensin	Streptomyces cinnamonensis
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0000100.5	0.67	PKS	monensin	Streptomyces cinnamonensis
BGC0002192.3	0.67	PKS	FR901512	fungal sp. No.14919
BGC0002154.2	0.67	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 102840:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-mal) + (Me-redmal) + (ccmal - Me-redmal) + (Me-ccmal - redmal) + (Me-ccmal - redmal) + (ohmal) + (Me-ohmal) + (Me-ohmal - Me-ccmal)
Non-colinear ordering:: ladSI + ladSII + ladSIII + ladSIV + ladSV + ladSVI + ladSVII + ladSVIII

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ladSI: mal - mmal

PKS_AT (541..845): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 193.2
inactive: 96.6
Methoxymalonyl-CoA: 68.2
Methylmalonyl-CoA: 50.9
Isobutyryl-CoA: 36.6
Propionyl-CoA: 29.6
Benzoyl-CoA: 23.8
Ethylmalonyl-CoA: 17.2
Acetyl-CoA: 13.9
CHC-CoA: 10.0
2-Methylbutyryl-CoA: 9.8
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (1551..1845): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 207.2
Ethylmalonyl-CoA: 197.5
Methoxymalonyl-CoA: 170.8
2-Methylbutyryl-CoA: 143.7
trans-1,2-CPDA: 125.2
Propionyl-CoA: 120.2
CHC-CoA: 117.4
Malonyl-CoA: 108.1
Isobutyryl-CoA: 75.9
Benzoyl-CoA: 52.1
fatty_acid: 47.5
Acetyl-CoA: 45.9
3-Methylbutyryl-CoA: 34.1
inactive: 25.3

ladSII: mmal

PKS_AT (564..858): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 203.4
Ethylmalonyl-CoA: 196.8
Methoxymalonyl-CoA: 165.8
2-Methylbutyryl-CoA: 136.4
trans-1,2-CPDA: 123.4
Propionyl-CoA: 122.2
CHC-CoA: 114.5
Malonyl-CoA: 108.3
Isobutyryl-CoA: 68.3
Acetyl-CoA: 57.8
fatty_acid: 56.0
Benzoyl-CoA: 43.8
3-Methylbutyryl-CoA: 38.5
inactive: 29.6

ladSIII: mal - mmal

PKS_AT (586..887): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 220.2
inactive: 108.5
Methoxymalonyl-CoA: 54.5
Methylmalonyl-CoA: 52.1
Isobutyryl-CoA: 30.6
Propionyl-CoA: 26.7
Benzoyl-CoA: 20.5
2-Methylbutyryl-CoA: 20.1
Acetyl-CoA: 19.2
Ethylmalonyl-CoA: 18.7
CHC-CoA: 8.3
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2373..2667): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 202.1
Ethylmalonyl-CoA: 198.6
Methoxymalonyl-CoA: 164.4
2-Methylbutyryl-CoA: 135.3
Propionyl-CoA: 120.0
trans-1,2-CPDA: 118.1
CHC-CoA: 104.6
Malonyl-CoA: 103.9
Isobutyryl-CoA: 72.2
Acetyl-CoA: 58.8
fatty_acid: 52.0
Benzoyl-CoA: 44.5
3-Methylbutyryl-CoA: 32.0
inactive: 23.2

ladSIV: mmal - mal

PKS_AT (568..862): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 201.5
Ethylmalonyl-CoA: 196.4
Methoxymalonyl-CoA: 163.4
2-Methylbutyryl-CoA: 132.5
trans-1,2-CPDA: 116.5
Propionyl-CoA: 116.4
Malonyl-CoA: 105.4
CHC-CoA: 104.8
Isobutyryl-CoA: 71.6
Acetyl-CoA: 59.0
fatty_acid: 52.4
Benzoyl-CoA: 47.9
3-Methylbutyryl-CoA: 33.1
inactive: 26.3

PKS_AT (2301..2584): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.5
inactive: 101.4
Methoxymalonyl-CoA: 75.4
Methylmalonyl-CoA: 70.9
Propionyl-CoA: 46.7
fatty_acid: 45.4
Isobutyryl-CoA: 44.4
Ethylmalonyl-CoA: 34.6
Acetyl-CoA: 34.5
trans-1,2-CPDA: 27.3
Benzoyl-CoA: 25.2
CHC-CoA: 19.5
2-Methylbutyryl-CoA: 19.2
3-Methylbutyryl-CoA: 10.7

ladSV: mmal - mal

PKS_AT (563..857): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 201.8
Ethylmalonyl-CoA: 198.7
Methoxymalonyl-CoA: 165.3
2-Methylbutyryl-CoA: 136.5
Propionyl-CoA: 119.6
trans-1,2-CPDA: 115.7
CHC-CoA: 105.4
Malonyl-CoA: 103.5
Isobutyryl-CoA: 73.0
Acetyl-CoA: 59.4
fatty_acid: 53.5
Benzoyl-CoA: 45.7
3-Methylbutyryl-CoA: 33.4
inactive: 23.9

PKS_AT (2318..2601): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 197.0
inactive: 101.2
Methoxymalonyl-CoA: 73.5
Methylmalonyl-CoA: 68.3
Propionyl-CoA: 48.0
fatty_acid: 43.7
Isobutyryl-CoA: 36.1
Acetyl-CoA: 35.6
Ethylmalonyl-CoA: 32.3
trans-1,2-CPDA: 25.6
Benzoyl-CoA: 25.0
CHC-CoA: 21.2
2-Methylbutyryl-CoA: 20.7
3-Methylbutyryl-CoA: 10.4

ladSVI: mal

PKS_AT (569..863): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 197.6
inactive: 100.7
Methoxymalonyl-CoA: 74.3
Methylmalonyl-CoA: 71.0
Isobutyryl-CoA: 47.8
Propionyl-CoA: 46.3
fatty_acid: 44.2
Ethylmalonyl-CoA: 33.9
Acetyl-CoA: 33.9
trans-1,2-CPDA: 27.3
Benzoyl-CoA: 24.0
CHC-CoA: 19.4
2-Methylbutyryl-CoA: 19.0
3-Methylbutyryl-CoA: 10.9

ladSVIII: mmal - mmal

PKS_AT (560..854): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 195.5
Ethylmalonyl-CoA: 194.4
Methoxymalonyl-CoA: 155.8
2-Methylbutyryl-CoA: 124.5
trans-1,2-CPDA: 118.7
Propionyl-CoA: 117.9
CHC-CoA: 112.2
Malonyl-CoA: 93.2
Isobutyryl-CoA: 78.9
Benzoyl-CoA: 50.3
Acetyl-CoA: 46.4
fatty_acid: 43.8
3-Methylbutyryl-CoA: 34.3
inactive: 24.0

PKS_AT (2102..2397): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 212.5
Ethylmalonyl-CoA: 207.4
Methoxymalonyl-CoA: 173.8
2-Methylbutyryl-CoA: 145.1
trans-1,2-CPDA: 128.4
Propionyl-CoA: 122.8
Malonyl-CoA: 111.3
CHC-CoA: 110.7
Isobutyryl-CoA: 76.3
Benzoyl-CoA: 53.8
Acetyl-CoA: 47.8
fatty_acid: 46.9
3-Methylbutyryl-CoA: 41.8
inactive: 23.9

ladSVII: mmal

PKS_AT (564..858): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.8
Ethylmalonyl-CoA: 197.8
Methoxymalonyl-CoA: 164.7
2-Methylbutyryl-CoA: 130.9
trans-1,2-CPDA: 122.4
Propionyl-CoA: 113.7
CHC-CoA: 105.6
Malonyl-CoA: 95.5
Isobutyryl-CoA: 79.6
Acetyl-CoA: 56.7
Benzoyl-CoA: 50.9
fatty_acid: 41.7
3-Methylbutyryl-CoA: 33.2
inactive: 20.6

Link to PARAS substrate predictor