BGC0000085: lankamycin biosynthetic gene cluster from Streptomyces rochei
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Location: 43,059 - 111,152 nt. (total: 68,094 nt).
This entry is originally from NCBI GenBank AB088224.2.

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core biosynthetic genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000085
Short description lankamycin biosynthetic gene cluster from Streptomyces rochei
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
AB088224.2
43059 - 111152
via
Compounds
  • lankamycin
Species Streptomyces rochei [taxonomy]
References
Chemical products information
lankamycin Evidence:
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C42H72O16
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAC76482.1
  • lkmD
 43059 - 44045 (-) putative NDP-hexose 4,6-dehydratase
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    • BAC76483.1
    • lkmE
    		 44059 - 44850 (-) putative thioesterase
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      • BAC76484.1
      • lkmF
      		 44847 - 46067 (-) P450 hydroxylase LkmF
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        • BAC76485.2
        • lkmBIII
        		 46101 - 47336 (-) putative NDP-4-keto-2,6-dideoxyhexose 3-C-methyltransferase
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          • BAC76486.1
          • lkmG
          		 47351 - 48163 (-) putative NDP-hexose 3-O-methyltransferase
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            • BAC76487.1
            • lkmBII
            		 48216 - 49223 (-) putative NDP-4-keto-2,6-dideoxyhexose 2,3-enoyl reductase
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              • BAC76488.1
              • lkmH
              		 49268 - 51709 (-) putative beta-glycosidase
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                • BAC76489.1
                • lkmI
                		 51875 - 53152 (-) glycosyltransferase LkmI
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                  • BAC76490.1
                  • lkmCII
                  		 53164 - 54249 (-) putative NDP-4-keto-6-deoxyhexose 3,4-isomerase
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                    • BAC76491.1
                    • lkmAIII
                    		 54246 - 64133 (-) lankamycin synthase LkmAIII
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                      • BAC76492.1
                      • lkmAII
                      		 64130 - 75100 (-) lankamycin synthase LkmAII
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                        • BAC76493.1
                        • lkmAI
                        		 75113 - 86068 (-) lankamycin synthase LkmAI
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                          • BAC76494.2
                          • lkmJ
                          		 86505 - 87728 (+) putative O-acyltransferase
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                            • BAC76495.1
                            • lkmK
                            		 87725 - 88939 (+) P450 hydroxylase LkmK
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                              • BAC76496.1
                              • lkmCIV
                              		 88944 - 90143 (+) putative NDP-6-deoxyhexose 3,4-dehydratase
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                                • BAC76497.1
                                • lkmCV
                                		 90186 - 91658 (+) putative NDP-4,6-dideoxyhexose 3,4-enoyl reductase
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                                  • BAC76498.1
                                  • lkmL
                                  		 91673 - 92950 (-) glycosyltransferase LkmL
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                                    • BAC76499.1
                                    • lkmBIV
                                    		 93108 - 94085 (+) putative NDP-3-methyl-4-keto-2,6-dideoxyhexose 4-ketoreductase
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                                      • BAC76500.2
                                      • lkmCVI
                                      		 94099 - 95019 (-) putative NDP-3-keto-6-deoxyhexose 3-ketoreductase
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                                        • BAC76501.1
                                        • lkmM
                                        		 95226 - 96395 (-) putative glycosyltransferase
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                                          • BAC76502.1
                                          • lkmN
                                          		 96823 - 98523 (+) putative ABC transporter protein
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                                            • BAC76503.1
                                            • lkmO
                                            		 98593 - 99489 (+) putative NDP-hexose 3-O-methyltransferase
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                                              • BAC76504.1
                                              • lkmBVII
                                              		 99510 - 100139 (+) putative NDP-4-keto-6-deoxyhexose 3,5-epimerase
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                                                • BAC76505.1
                                                • lkmP
                                                		 100212 - 101642 (-) probable adenosylhomocysteinase
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                                                  • BAC76506.1
                                                  • lkmQ
                                                  		 101632 - 102492 (-) probable 5,10-methylenetetrahydrofolate reductase
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                                                    • BAC76507.1
                                                    • lkmR
                                                    		 102489 - 105896 (-) probable 5-methyltetrahydrofolate-homocysteine S-methyltransferase
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                                                      • BAC76508.1
                                                      • lkmS
                                                      		 105935 - 106945 (-) putative glucose kinase
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                                                        • BAC76509.1
                                                        • lkmT
                                                        		 107035 - 108255 (-) probable S-adenosylmethionine synthetase
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                                                          • BAC76510.1
                                                          • lkmU
                                                          		 108557 - 109621 (-) putative NDP-glucose synthase
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                                                            • BAC76511.1
                                                            • lkmBVI
                                                            		 109701 - 111152 (+) putative NDP-4-keto-6-deoxyhexose 2,3-dehydratase
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                                                              Biosynthesis information
                                                              Annotation changelog

                                                              Entry version: 4

                                                              Date
                                                              Changes
                                                              Submitters
                                                              Reviewers
                                                              2022-10-07
                                                              Update chemical activity to schema version 2.11
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                              Entry version: 3

                                                              Date
                                                              Changes
                                                              Submitters
                                                              Reviewers
                                                              2022-09-15
                                                              Updated bioactivity data
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                              Entry version: 2

                                                              Date
                                                              Changes
                                                              Submitters
                                                              Reviewers
                                                              2019-10-16
                                                              Migrated from v1.4
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              2019-10-16
                                                              Updated compound(s) information (NPAtlas curation)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                              Entry version: 1

                                                              Date
                                                              Changes
                                                              Submitters
                                                              Reviewers
                                                              2015-06-12
                                                              Submitted
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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