BGC0000085 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000085 (Streptomyces rochei)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	68,094	lankamycin	PKS	100%

BGC0000085 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 68,094 nt. (total: 68,094 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 68,095
Label		BGC0000085

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000085	0.98	Polyketide	lankamycin	Streptomyces rochei
BGC0000278	0.38	Polyketide	urdamycin	Streptomyces fradiae
BGC0001661	0.38	Polyketide	mayamycin	Streptomyces sp.
BGC0000263	0.36	Polyketide	ravidomycin	Streptomyces ravidus
BGC0000226	0.35	Polyketide	gilvocarcin V	Streptomyces griseoflavus
BGC0002435	0.35	Other	coformycin, aristeromycin	Micromonospora haikouensis
BGC0001605	0.33	Terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0002031	0.32	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0000041	0.32	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000715	0.29	Saccharide	actinospectacin	Streptomyces spectabilis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000085	1.00	Polyketide	lankamycin	Streptomyces rochei
BGC0002435	0.68	Other	coformycin, aristeromycin	Micromonospora haikouensis
BGC0001605	0.67	Terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0002031	0.66	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0000041	0.65	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000016	0.62	Other	amphotericin B	Streptomyces nodosus
BGC0000067	0.62	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001163	0.62	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001817	0.61	Other	vancosamine	Streptomyces sp. WAC2288
BGC0000794	0.61	Saccharide	S-layer glycan	Geobacillus stearothermophilus

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 63010:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk - Me-ccmal - Me-ohmal) + (Me-ohmal - Me-redmal) + (Me-ohmal - Me-ohmal)
Non-colinear ordering:: lkmAI + lkmAII + lkmAIII

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

lkmAIII

PKS_AT (576..870): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 205.0
Ethylmalonyl-CoA: 184.6
Methoxymalonyl-CoA: 168.3
2-Methylbutyryl-CoA: 142.4
Propionyl-CoA: 110.4
trans-1,2-CPDA: 108.7
CHC-CoA: 106.3
Malonyl-CoA: 98.0
Isobutyryl-CoA: 69.2
Benzoyl-CoA: 61.8
Acetyl-CoA: 44.0
fatty_acid: 40.3
inactive: 28.3
3-Methylbutyryl-CoA: 26.0

PKS_AT (2079..2375): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 215.6
Ethylmalonyl-CoA: 206.0
Methoxymalonyl-CoA: 178.0
2-Methylbutyryl-CoA: 160.7
trans-1,2-CPDA: 124.9
Malonyl-CoA: 122.2
Propionyl-CoA: 119.9
CHC-CoA: 103.0
Isobutyryl-CoA: 89.6
3-Methylbutyryl-CoA: 51.3
Benzoyl-CoA: 47.4
Acetyl-CoA: 41.2
inactive: 36.3
fatty_acid: 22.9

lkmAII

PKS_AT (562..862): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.2
Ethylmalonyl-CoA: 200.0
Methoxymalonyl-CoA: 178.0
2-Methylbutyryl-CoA: 150.8
trans-1,2-CPDA: 126.4
Propionyl-CoA: 118.6
Malonyl-CoA: 115.9
CHC-CoA: 102.2
Isobutyryl-CoA: 101.7
Benzoyl-CoA: 65.1
Acetyl-CoA: 60.4
inactive: 48.2
fatty_acid: 37.0
3-Methylbutyryl-CoA: 30.1

PKS_AT (2063..2360): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.9
Ethylmalonyl-CoA: 194.2
Methoxymalonyl-CoA: 168.6
2-Methylbutyryl-CoA: 145.2
Propionyl-CoA: 111.7
trans-1,2-CPDA: 104.1
Malonyl-CoA: 90.5
Isobutyryl-CoA: 89.5
CHC-CoA: 82.8
Benzoyl-CoA: 62.8
3-Methylbutyryl-CoA: 61.4
Acetyl-CoA: 52.5
inactive: 34.9
fatty_acid: 33.2

lkmAI

PKS_AT (108..405): pk

ATSignature: 2-Methylbutyryl-CoA

Top 3 matches:: 2-Methylbutyryl-CoA: 100.0%; Propionyl-CoA: 79.2%; Methylmalonyl-CoA: 70.8%

minowa: 2-Methylbutyryl-CoA

Prediction, score:

2-Methylbutyryl-CoA: 257.4
Propionyl-CoA: 151.9
Methylmalonyl-CoA: 135.3
Ethylmalonyl-CoA: 108.1
Methoxymalonyl-CoA: 104.8
CHC-CoA: 80.6
Malonyl-CoA: 75.2
trans-1,2-CPDA: 71.5
Isobutyryl-CoA: 41.7
Acetyl-CoA: 33.5
Benzoyl-CoA: 33.1
fatty_acid: 26.7
inactive: 25.4
3-Methylbutyryl-CoA: 21.6

PKS_AT (1126..1432): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 211.7
Ethylmalonyl-CoA: 208.6
Methoxymalonyl-CoA: 172.0
2-Methylbutyryl-CoA: 133.3
trans-1,2-CPDA: 124.0
Propionyl-CoA: 112.4
Malonyl-CoA: 105.6
CHC-CoA: 97.5
Isobutyryl-CoA: 73.5
fatty_acid: 61.7
Benzoyl-CoA: 59.6
Acetyl-CoA: 44.9
3-Methylbutyryl-CoA: 27.8
inactive: 20.6

PKS_AT (2630..2922): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 202.5
Ethylmalonyl-CoA: 188.2
Methoxymalonyl-CoA: 162.0
2-Methylbutyryl-CoA: 133.8
trans-1,2-CPDA: 115.2
CHC-CoA: 102.8
Propionyl-CoA: 95.8
Malonyl-CoA: 94.5
Isobutyryl-CoA: 73.9
Benzoyl-CoA: 43.9
3-Methylbutyryl-CoA: 41.9
Acetyl-CoA: 37.5
inactive: 21.2
fatty_acid: 18.6