BGC0000086 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000086 (Streptomyces lasalocidi)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	81,959	lasalocid	PKS	100%

BGC0000086 - Region 1 - T1PKS

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Location: 1 - 81,959 nt. (total: 81,959 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 81,960
Label		BGC0000086

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000086	1.00	Polyketide	lasalocid	Streptomyces lasaliensis
BGC0000087	0.56	Polyketide	lasalocid	Streptomyces lasaliensis
BGC0000016	0.40	Other	amphotericin B	Streptomyces nodosus
BGC0000041	0.33	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001850	0.32	Other (Shikimate-derived)	diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G	Streptomyces sp. F001
BGC0002227	0.31	NRP	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0000067	0.31	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001164	0.31	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001749	0.31	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0001273	0.31	Polyketide	asperlactone	Aspergillus ochraceus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000086	1.00	Polyketide	lasalocid	Streptomyces lasaliensis
BGC0000087	0.82	Polyketide	lasalocid	Streptomyces lasaliensis
BGC0000016	0.72	Other	amphotericin B	Streptomyces nodosus
BGC0000041	0.67	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001850	0.65	Other (Shikimate-derived)	diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G	Streptomyces sp. F001
BGC0002227	0.65	NRP	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0000067	0.65	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001164	0.64	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001749	0.64	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0001273	0.64	Polyketide	asperlactone	Aspergillus ochraceus

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 81959:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - pk - redmal) + (pk - Me-redmal - pk) + (Me-mal) + (Me-ohmal) + (redmal - ohmal) + (Me-ccmal) + (mal)
Non-colinear ordering:: lsd11 + lsd12 + lsd13 + lsd14 + lsd15 + lsd16 + lsd17

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

lsd11

PKS_AT (443..742): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 232.3
inactive: 106.5
Methoxymalonyl-CoA: 83.3
Methylmalonyl-CoA: 66.9
Propionyl-CoA: 52.9
Isobutyryl-CoA: 43.2
Ethylmalonyl-CoA: 30.0
2-Methylbutyryl-CoA: 29.3
Benzoyl-CoA: 22.7
fatty_acid: 20.6
Acetyl-CoA: 20.3
CHC-CoA: 14.7
3-Methylbutyryl-CoA: 13.0
trans-1,2-CPDA: 0.0

PKS_AT (1489..1780): pk

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Methylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 184.0
Ethylmalonyl-CoA: 174.0
Methoxymalonyl-CoA: 148.4
2-Methylbutyryl-CoA: 119.6
trans-1,2-CPDA: 114.4
CHC-CoA: 104.0
Malonyl-CoA: 96.8
Propionyl-CoA: 90.6
Isobutyryl-CoA: 66.8
Benzoyl-CoA: 32.1
fatty_acid: 30.5
inactive: 27.7
Acetyl-CoA: 26.1
3-Methylbutyryl-CoA: 21.3

PKS_AT (3292..3578): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 189.8
inactive: 87.2
Methoxymalonyl-CoA: 49.0
Methylmalonyl-CoA: 34.4
Propionyl-CoA: 27.2
Acetyl-CoA: 17.7
fatty_acid: 17.5
Benzoyl-CoA: 14.7
trans-1,2-CPDA: 14.0
Isobutyryl-CoA: 12.3
2-Methylbutyryl-CoA: 9.4
CHC-CoA: 7.1
Ethylmalonyl-CoA: 6.0
3-Methylbutyryl-CoA: 0.0

lsd12

PKS_AT (526..817): pk

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Methylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 187.0
Ethylmalonyl-CoA: 175.0
Methoxymalonyl-CoA: 152.0
2-Methylbutyryl-CoA: 118.5
trans-1,2-CPDA: 116.8
CHC-CoA: 105.1
Malonyl-CoA: 97.8
Propionyl-CoA: 90.6
Isobutyryl-CoA: 64.8
Benzoyl-CoA: 34.7
fatty_acid: 30.8
inactive: 30.6
Acetyl-CoA: 27.0
3-Methylbutyryl-CoA: 26.9

PKS_AT (2283..2580): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.7
Ethylmalonyl-CoA: 186.2
Methoxymalonyl-CoA: 160.7
2-Methylbutyryl-CoA: 133.6
trans-1,2-CPDA: 124.5
CHC-CoA: 97.3
Propionyl-CoA: 95.5
Malonyl-CoA: 80.7
Isobutyryl-CoA: 58.1
Benzoyl-CoA: 45.4
3-Methylbutyryl-CoA: 23.5
Acetyl-CoA: 17.5
fatty_acid: 16.4
inactive: 13.9

PKS_AT (4349..4640): pk

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Methylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 186.2
Ethylmalonyl-CoA: 174.2
Methoxymalonyl-CoA: 151.1
2-Methylbutyryl-CoA: 123.7
trans-1,2-CPDA: 111.6
CHC-CoA: 106.7
Malonyl-CoA: 99.3
Propionyl-CoA: 90.6
Isobutyryl-CoA: 68.0
Benzoyl-CoA: 34.2
inactive: 32.8
fatty_acid: 31.2
Acetyl-CoA: 24.8
3-Methylbutyryl-CoA: 24.5

lsd13

PKS_AT (569..866): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 197.1
Ethylmalonyl-CoA: 183.6
Methoxymalonyl-CoA: 156.0
2-Methylbutyryl-CoA: 131.7
trans-1,2-CPDA: 122.6
Propionyl-CoA: 94.1
CHC-CoA: 93.9
Malonyl-CoA: 78.9
Isobutyryl-CoA: 58.2
Benzoyl-CoA: 44.5
3-Methylbutyryl-CoA: 22.0
Acetyl-CoA: 18.9
fatty_acid: 15.4
inactive: 12.3

lsd14

PKS_AT (567..864): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.8
Ethylmalonyl-CoA: 178.6
Methoxymalonyl-CoA: 153.7
2-Methylbutyryl-CoA: 130.4
trans-1,2-CPDA: 121.5
Propionyl-CoA: 93.8
CHC-CoA: 92.0
Malonyl-CoA: 79.4
Isobutyryl-CoA: 53.7
Benzoyl-CoA: 42.3
3-Methylbutyryl-CoA: 24.5
Acetyl-CoA: 22.5
fatty_acid: 16.4
inactive: 11.2

lsd15

PKS_AT (564..850): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 180.5
inactive: 81.5
Methoxymalonyl-CoA: 43.8
Methylmalonyl-CoA: 29.9
Propionyl-CoA: 22.4
Acetyl-CoA: 15.2
fatty_acid: 12.5
2-Methylbutyryl-CoA: 12.1
Benzoyl-CoA: 11.9
Isobutyryl-CoA: 11.7
trans-1,2-CPDA: 9.8
CHC-CoA: 0.5
Ethylmalonyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2654..2939): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 180.2
inactive: 81.2
Methoxymalonyl-CoA: 42.4
Methylmalonyl-CoA: 30.7
Propionyl-CoA: 23.0
Acetyl-CoA: 15.2
fatty_acid: 12.5
2-Methylbutyryl-CoA: 12.1
CHC-CoA: 12.0
Benzoyl-CoA: 11.9
Isobutyryl-CoA: 11.7
trans-1,2-CPDA: 11.3
Ethylmalonyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

lsd16

PKS_AT (605..902): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 196.4
Ethylmalonyl-CoA: 182.0
Methoxymalonyl-CoA: 155.0
2-Methylbutyryl-CoA: 138.1
trans-1,2-CPDA: 121.6
Propionyl-CoA: 96.9
CHC-CoA: 93.7
Malonyl-CoA: 81.3
Isobutyryl-CoA: 55.4
Benzoyl-CoA: 50.2
3-Methylbutyryl-CoA: 25.4
fatty_acid: 21.6
Acetyl-CoA: 18.1
inactive: 14.7

lsd17

PKS_AT (525..804): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 184.5
inactive: 82.7
Methoxymalonyl-CoA: 43.7
Methylmalonyl-CoA: 30.1
Propionyl-CoA: 23.1
Acetyl-CoA: 14.9
fatty_acid: 13.9
Benzoyl-CoA: 12.1
Isobutyryl-CoA: 12.0
trans-1,2-CPDA: 9.7
2-Methylbutyryl-CoA: 8.9
CHC-CoA: 6.0
Ethylmalonyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0