BGC0000088: monacolin K biosynthetic gene cluster from Aspergillus terreus
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Location: 1 - 55,428 nt. (total: 55,428 nt).
This entry is originally from NCBI GenBank AH007774.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000088
Short description monacolin K biosynthetic gene cluster from Aspergillus terreus
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: AH007774.2
Compounds
  • monacolin K
Species Aspergillus terreus [taxonomy]
References
Chemical products information
monacolin K [synonyms: lovastatin, mevinolin]
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C24H36O5
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAD34550.1
 1813 - 6865 (-) esterase
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  • AAD34551.1
 7616 - 8602 (+) unknown
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  • AAD34552.1
  • lovA
 9980 - 11712 (-) cytochrome P450 monooxygenase
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  • AAD34553.1
 13090 - 13860 (-) unknown
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  • AAD34554.1
  • lovC
 14258 - 15510 (+) enoyl reductase
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  • AAD34555.1
  • lovD
 15910 - 17303 (-) transesterase
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  • AAD34556.1
 17659 - 21162 (-) hydroxymethylglutaryl-coenzyme A reductase
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  • AAD34557.1
  • lovE
 22460 - 23971 (+) regulatory protein
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  • AAD34558.1
 25500 - 27660 (+) unknown
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  • AAD34559.1
  • lovF
 28530 - 36564 (+) polyketide synthase
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  • AAD34560.1
 36809 - 37696 (-) unknown
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  • AAD34561.1
 38231 - 40708 (-) regulatory protein
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  • AAD34562.1
 42441 - 43742 (-) unknown
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  • AAD34563.1
 44432 - 45960 (+) unknown
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  • AAD34564.1
 46918 - 48621 (-) unknown
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  • AAD34565.1
 50937 - 52625 (-) cytochrome P450 monooxygenase
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  • AAD34566.1
 53926 - >55428 (+) unknown
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated reference publication(s) (MIBiG Annotathon)
  • Updated compound(s) information (NPAtlas curation)
  • Updated loci information
3.0
  • Hidden contributor (ID: 3UOU7PODQJXIM6BEPUHHRRA5, no GDPR consent given).
  • Add synonyms
Detailed domain annotation
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