Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000090.1:
Cluster 1Polyketide1100588

BGC0000090, macbecin biosynthetic gene cluster from Actinosynnema pretiosum. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Macbecin I
PubChem ID: 10886216
SMILES string: Copy to clipboard
Molecular formula: C30H42N2O8
Average molecular mass: 558.672 Da
Molecular activity: Cytotoxic, Other
Molecular target: Hsp90

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Ansamycin (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
3,5-AHBA-CoA
Thioesterase type:
None
Release / cyclization type:
Macrolactamization

Gene cluster description

macbecin (BGC0000090). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank EU827593, positions 14925-80716. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Professor Barrie Wilkinson (John Innes Centre)

Literature references

1. Zhang MQ et al. (2008) Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors. J Med Chem 51(18):5494-7. doi: 10.1021/jm8006068.