BGC0000092: megalomicin A biosynthetic gene cluster from Micromonospora megalomicea subsp. nigra
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 47,981 nt. (total: 47,981 nt).
This entry is originally from NCBI GenBank AF263245.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000092
Short description megalomicin A biosynthetic gene cluster from Micromonospora megalomicea subsp. nigra
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: AF263245.1
Compounds
  • megalomicin A
  • megalomicin B
  • megalomicin C1
  • megalomicin C2
Species Micromonospora megalomicea subsp. nigra [taxonomy]
References
Chemical products information
megalomicin A
Copy SMILES
C44H80N2O15
Chemical database entries
PubCHEM
megalomicin B
Copy SMILES
C46H82N2O16
Chemical database entries
PubCHEM
megalomicin C1
Copy SMILES
C48H84N2O17
Chemical database entries
PubCHEM
megalomicin C2
Copy SMILES
C49H86N2O17
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAG13906.1
  • megT
 1 - 144 (-) TDP-4-keto-6-deoxyglucose-2,3-dehydratase
copy AA seq
copy Nt seq
  • AAG13907.1
  • megDVI
 928 - 2061 (+) TDP-4-keto-6-deoxyhexose 3,4-isomerase
copy AA seq
copy Nt seq
  • AAG13908.1
  • megDI
 2072 - 3382 (+) TDP-megosamine glycosyltransferase
copy AA seq
copy Nt seq
  • AAG13909.1
  • megY
 3462 - 4634 (+) mycarose O-acyltransferase
copy AA seq
copy Nt seq
  • AAG13910.1
  • megDII
 4651 - 5775 (+) TDP-3-keto-6-deoxyhexose 3-aminotransaminase
copy AA seq
copy Nt seq
  • AAG13912.1
  • megDIII
 5822 - 6595 (+) daunosaminyl-N,N-dimethyltransferase
copy AA seq
copy Nt seq
  • AAG13911.1
  • megDIV
 6592 - 7197 (+) TDP-4-keto-6-deoxyhexose 3,5-epimerase
copy AA seq
copy Nt seq
  • AAG13913.1
  • megDV
 7220 - 8206 (+) TDP-4-keto-6-deoxyhexose 4-ketoreductase
copy AA seq
copy Nt seq
  • AAG13914.1
  • megDVII
 8228 - 9220 (-) TDP-4-keto-6-deoxyhexose 2,3-reductase
copy AA seq
copy Nt seq
  • AAG13915.1
  • megBV
 9226 - 10479 (-) TDP-mycarose glycosyltransferase
copy AA seq
copy Nt seq
  • AAG13916.1
  • megBIV
 10483 - 11424 (-) TDP-4-keto-6-deoxyhexose 4-ketoreductase
copy AA seq
copy Nt seq
  • AAG13917.1
  • megAI
 12181 - 22821 (+) megalomicin 6-deoxyerythronolide B synthase 1
copy AA seq
copy Nt seq
  • AAG13918.1
  • megAII
 22867 - 33555 (+) megalomicin 6-deoxyerythronolide B synthase 2
copy AA seq
copy Nt seq
  • AAG13919.1
  • megAIII
 33666 - 43271 (+) megalomicin 6-deoxyerythronolide B synthase 3
copy AA seq
copy Nt seq
  • AAG13920.1
  • megCII
 43268 - 44344 (+) TDP-4-keto-6-deoxyglucose 3,4-isomerase
copy AA seq
copy Nt seq
  • AAG13921.1
  • megCIII
 44355 - 45623 (+) TDP-desosamine glycosyltransferase
copy AA seq
copy Nt seq
  • AAG13922.1
  • megBII
 45620 - 46591 (+) TDP-4-keto-6-deoxyglucose 2,3 dehydratase
copy AA seq
copy Nt seq
  • AAG13923.1
  • megH
 46660 - 47403 (-) TEII
copy AA seq
copy Nt seq
  • AAG13924.1
  • megF
 47411 - >47980 (-) C-6 hydroxylase
copy AA seq
copy Nt seq
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (MIBiG Annotathon)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.