BGC0000094 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000094 (Streptomyces venezuelae)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	37,948	High	methymycin	PKS:Type I+saccharide:hybrid/tailoring

BGC0000094 - Region 1 - T1PKS

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Location: 1 - 37,948 nt. (total: 37,948 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 37,949
Label		BGC0000094

Tailoring functions

Transferases: acylase

pikAIV: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: esterase

pikAV: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: synthase

pikAI: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

pikAII: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

pikAIII: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000094.5	1.00	PKS, saccharide	methymycin	Streptomyces venezuelae
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.75	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000041.3	0.73	PKS	oronofacic acid	Pseudomonas syringae
BGC0001276.3	0.67	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000094.5	1.00	PKS, saccharide	methymycin	Streptomyces venezuelae
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.75	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000041.3	0.73	PKS	oronofacic acid	Pseudomonas syringae
BGC0001276.3	0.67	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 37948:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - Me-ccmal - ccmal) + (Me-ohmal - Me-redmal) + (Me-ohmal) + (Me-mal)
Non-colinear ordering:: pikAI + pikAII + pikAIII + pikAIV

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

pikAI: mmal - mmal - mal

PKS_AT (634..917): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.0
Ethylmalonyl-CoA: 184.9
Methoxymalonyl-CoA: 156.8
2-Methylbutyryl-CoA: 132.7
Propionyl-CoA: 109.5
trans-1,2-CPDA: 100.5
CHC-CoA: 90.2
Malonyl-CoA: 81.3
Isobutyryl-CoA: 53.7
Acetyl-CoA: 40.5
Benzoyl-CoA: 39.6
fatty_acid: 34.8
3-Methylbutyryl-CoA: 18.0
inactive: 13.3

PKS_AT (1650..1934): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 211.4
Ethylmalonyl-CoA: 186.1
Methoxymalonyl-CoA: 157.4
2-Methylbutyryl-CoA: 134.3
Propionyl-CoA: 112.0
trans-1,2-CPDA: 104.2
CHC-CoA: 92.8
Malonyl-CoA: 84.7
Isobutyryl-CoA: 52.7
Acetyl-CoA: 40.7
Benzoyl-CoA: 33.8
fatty_acid: 33.4
3-Methylbutyryl-CoA: 15.8
inactive: 13.5

PKS_AT (3180..3474): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 232.8
inactive: 116.9
Methoxymalonyl-CoA: 79.7
Methylmalonyl-CoA: 73.8
Propionyl-CoA: 44.1
Isobutyryl-CoA: 41.0
Ethylmalonyl-CoA: 36.9
2-Methylbutyryl-CoA: 31.2
Acetyl-CoA: 29.6
Benzoyl-CoA: 20.3
CHC-CoA: 19.0
fatty_acid: 16.9
trans-1,2-CPDA: 16.1
3-Methylbutyryl-CoA: 0.0

pikAII: mmal - mmal

PKS_AT (572..856): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.6
Ethylmalonyl-CoA: 185.2
Methoxymalonyl-CoA: 158.3
2-Methylbutyryl-CoA: 125.3
Propionyl-CoA: 104.8
trans-1,2-CPDA: 100.8
CHC-CoA: 89.7
Malonyl-CoA: 75.5
Isobutyryl-CoA: 52.6
Benzoyl-CoA: 34.1
fatty_acid: 33.3
Acetyl-CoA: 31.3
3-Methylbutyryl-CoA: 14.9
inactive: 12.5

PKS_AT (2069..2353): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.3
Ethylmalonyl-CoA: 184.2
Methoxymalonyl-CoA: 158.5
2-Methylbutyryl-CoA: 130.7
Propionyl-CoA: 105.9
trans-1,2-CPDA: 101.6
CHC-CoA: 88.0
Malonyl-CoA: 80.4
Isobutyryl-CoA: 49.9
fatty_acid: 39.0
Benzoyl-CoA: 37.9
Acetyl-CoA: 35.3
3-Methylbutyryl-CoA: 22.2
inactive: 13.2

pikAIII: mmal

PKS_AT (565..848): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 206.2
Ethylmalonyl-CoA: 182.3
Methoxymalonyl-CoA: 154.8
2-Methylbutyryl-CoA: 128.9
Propionyl-CoA: 110.6
trans-1,2-CPDA: 103.6
CHC-CoA: 88.8
Malonyl-CoA: 72.4
Isobutyryl-CoA: 45.5
fatty_acid: 33.8
Acetyl-CoA: 30.8
Benzoyl-CoA: 29.5
3-Methylbutyryl-CoA: 13.6
inactive: 12.8

pikAIV: mmal

PKS_AT (562..843): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.5
Ethylmalonyl-CoA: 185.1
Methoxymalonyl-CoA: 158.7
2-Methylbutyryl-CoA: 124.6
Propionyl-CoA: 104.4
trans-1,2-CPDA: 99.1
CHC-CoA: 88.5
Malonyl-CoA: 77.2
Isobutyryl-CoA: 50.2
Benzoyl-CoA: 32.3
fatty_acid: 31.5
Acetyl-CoA: 29.4
3-Methylbutyryl-CoA: 13.3
inactive: 12.8

Link to PARAS substrate predictor