Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000094.1:
Cluster 1Polyketide / Saccharide137948

BGC0000094, methymycin / pikromycin biosynthetic gene cluster from Streptomyces venezuelae. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: methymycin
SMILES string: Copy to clipboard
Molecular formula: C25H43NO7
Exact molecular mass: 469.304 Da ([M+H]+)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
Polyketide / Saccharide
Polyketide subclass:
Macrolide (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
Malonyl-CoA
Thioesterase type:
Type II
Release / cyclization type:
Macrolactamization

Modular polyketide synthases:
pikAI (AAC69329.1)
Module 0
AT specificity: Propionyl-CoA
Evidence for specificity: Structure-based inference
Scaffold-modifying domain: None
Module 1
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group
Scaffold-modifying domain: None
Module 2
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group
Scaffold-modifying domain: None

pikAII (AAC69330.1)
Module 3
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Inactive
Scaffold-modifying domain: None
Module 4
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group
Scaffold-modifying domain: None

pikAIII (AAC69331.1)
Module 5
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group
Scaffold-modifying domain: None

pikAIV (AAC69332.1)
Module 6
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Scaffold-modifying domain: None

Gene cluster description

methymycin / pikromycin (BGC0000094). Gene Cluster 1. Biosynthetic class = Polyketide/Saccharide. GenBank AF079138, positions 1-37948. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?partial
Evidence for cluster-compound connection:Enzymatic assays
MIxS-compliance:Unknown
Contact for this cluster:Fengan Yu (University of Michigan)

Literature references

1. Xue Y et al. (1998) A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity. Proc Natl Acad Sci U S A 95(21):12111-6.