BGC0000096 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000096 (Streptomyces mycarofaciens)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	84,428	midecamycin	PKS	97%

BGC0000096 - Region 1 - T1PKS

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Location: 1 - 84,428 nt. (total: 84,428 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 84,429
Label		BGC0000096

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000096	0.84	Polyketide	midecamycin	Streptomyces mycarofaciens
BGC0000113	0.43	Polyketide	niddamycin	Streptomyces caelestis
BGC0000041	0.42	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000067	0.34	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001276	0.34	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001163	0.31	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001749	0.31	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0002233	0.31	Polyketide	trichoxide	Trichoderma virens Gv29-8
BGC0000706	0.30	Saccharide	kanamycin	Streptomyces kanamyceticus
BGC0002234	0.30	Polyketide	flavoglaucin	Aspergillus ruber CBS 135680

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000096	0.98	Polyketide	midecamycin	Streptomyces mycarofaciens
BGC0000706	0.75	Saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000113	0.74	Polyketide	niddamycin	Streptomyces caelestis
BGC0000041	0.73	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000067	0.67	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001276	0.67	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001163	0.65	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001749	0.65	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0002233	0.64	Polyketide	trichoxide	Trichoderma virens Gv29-8
BGC0002234	0.64	Polyketide	flavoglaucin	Aspergillus ruber CBS 135680

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 9417 - 84428:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ccmal - ccmal) + (ccmal) + (ohmxmal) + (Me-ohmal - redemal) + (ccmal)
Non-colinear ordering:: ctg1_orf27 + ctg1_orf28 + ctg1_orf30 + ctg1_orf29 + ctg1_orf31

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg1_orf27

PKS_AT (469..770): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.2
inactive: 116.2
Methylmalonyl-CoA: 73.3
Methoxymalonyl-CoA: 64.7
Propionyl-CoA: 49.2
Isobutyryl-CoA: 33.6
Ethylmalonyl-CoA: 26.0
fatty_acid: 24.8
Benzoyl-CoA: 21.7
Acetyl-CoA: 18.2
2-Methylbutyryl-CoA: 12.4
CHC-CoA: 12.3
trans-1,2-CPDA: 4.9
3-Methylbutyryl-CoA: 0.0

PKS_AT (1507..1808): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 212.3
inactive: 117.2
Methylmalonyl-CoA: 74.7
Methoxymalonyl-CoA: 66.5
Propionyl-CoA: 50.0
Isobutyryl-CoA: 36.5
Ethylmalonyl-CoA: 29.1
fatty_acid: 25.1
Benzoyl-CoA: 22.8
Acetyl-CoA: 17.5
2-Methylbutyryl-CoA: 14.0
CHC-CoA: 12.2
trans-1,2-CPDA: 5.3
3-Methylbutyryl-CoA: 0.0

PKS_AT (3074..3375): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 212.3
inactive: 117.2
Methylmalonyl-CoA: 74.7
Methoxymalonyl-CoA: 66.5
Propionyl-CoA: 50.0
Isobutyryl-CoA: 36.5
Ethylmalonyl-CoA: 29.1
fatty_acid: 25.1
Benzoyl-CoA: 22.8
Acetyl-CoA: 17.5
2-Methylbutyryl-CoA: 14.0
CHC-CoA: 12.2
trans-1,2-CPDA: 5.3
3-Methylbutyryl-CoA: 0.0

ctg1_orf28

PKS_AT (580..881): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 212.3
inactive: 117.2
Methylmalonyl-CoA: 74.7
Methoxymalonyl-CoA: 66.5
Propionyl-CoA: 50.0
Isobutyryl-CoA: 36.5
Ethylmalonyl-CoA: 29.1
fatty_acid: 25.1
Benzoyl-CoA: 22.8
Acetyl-CoA: 17.5
2-Methylbutyryl-CoA: 14.0
CHC-CoA: 12.2
trans-1,2-CPDA: 5.3
3-Methylbutyryl-CoA: 0.0

ctg1_orf29

PKS_AT (565..862): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 216.7
Ethylmalonyl-CoA: 206.1
Methoxymalonyl-CoA: 175.2
2-Methylbutyryl-CoA: 132.4
trans-1,2-CPDA: 124.7
Malonyl-CoA: 108.0
Propionyl-CoA: 107.5
CHC-CoA: 96.0
Isobutyryl-CoA: 72.2
Benzoyl-CoA: 68.5
fatty_acid: 40.3
Acetyl-CoA: 32.6
3-Methylbutyryl-CoA: 32.0
inactive: 30.6

PKS_AT (2061..2359): emal

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Methylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 235.4
Methylmalonyl-CoA: 204.3
Methoxymalonyl-CoA: 180.6
trans-1,2-CPDA: 159.9
2-Methylbutyryl-CoA: 158.5
Propionyl-CoA: 122.0
CHC-CoA: 100.8
Malonyl-CoA: 94.6
Isobutyryl-CoA: 83.9
Benzoyl-CoA: 61.2
Acetyl-CoA: 52.0
fatty_acid: 41.0
3-Methylbutyryl-CoA: 28.9
inactive: 27.0

ctg1_orf30

PKS_AT (566..863): mxmal

ATSignature: Methylmalonyl-CoA, Methoxymalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 100.0%; Ethylmalonyl-CoA: 91.7%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 194.6
Ethylmalonyl-CoA: 191.9
Methylmalonyl-CoA: 190.8
trans-1,2-CPDA: 127.1
2-Methylbutyryl-CoA: 116.7
Malonyl-CoA: 115.3
Propionyl-CoA: 96.1
Isobutyryl-CoA: 95.3
CHC-CoA: 82.8
Benzoyl-CoA: 68.3
3-Methylbutyryl-CoA: 55.3
Acetyl-CoA: 53.3
fatty_acid: 40.0
inactive: 34.5

ctg1_orf31

PKS_AT (580..879): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 195.3
inactive: 102.8
Methoxymalonyl-CoA: 65.4
Methylmalonyl-CoA: 54.4
Propionyl-CoA: 41.1
Isobutyryl-CoA: 37.9
Ethylmalonyl-CoA: 27.8
Benzoyl-CoA: 22.8
Acetyl-CoA: 18.9
2-Methylbutyryl-CoA: 12.5
CHC-CoA: 8.8
trans-1,2-CPDA: 7.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0