BGC0000098 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000098 (Monascus pilosus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	45,000	monacolin K	PKS	100%

BGC0000098 - Region 1 - T1PKS

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Location: 1 - 45,000 nt. (total: 45,000 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 45,001
Label		BGC0000098

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000098	1.23	Polyketide	monacolin K	Monascus pilosus
BGC0000088	0.71	Polyketide	monacolin K	Aspergillus terreus
BGC0000039	0.55	Polyketide	compactin	Penicillium citrinum
BGC0002192	0.53	Polyketide	FR901512	fungal sp. No.14919
BGC0001254	0.49	Polyketide	ACT-Toxin II	Alternaria alternata
BGC0002258	0.49	Polyketide	shimalactone A, shimalactone B	Aspergillus stellatus
BGC0001998	0.49	Polyketide	aspernidgulene A1, aspernidgulene A2, aspernidgulene B1	Aspergillus nidulans FGSC A4
BGC0002745	0.49	Polyketide	verrucosidin	Penicillium polonicum
BGC0002194	0.48	Polyketide	epipyrone A	Epicoccum nigrum
BGC0001400	0.48	Polyketide	citreoviridin	Aspergillus terreus NIH2624

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000098	1.00	Polyketide	monacolin K	Monascus pilosus
BGC0000088	0.74	Polyketide	monacolin K	Aspergillus terreus
BGC0000039	0.72	Polyketide	compactin	Penicillium citrinum
BGC0002192	0.72	Polyketide	FR901512	fungal sp. No.14919
BGC0001998	0.68	Polyketide	aspernidgulene A1, aspernidgulene A2, aspernidgulene B1	Aspergillus nidulans FGSC A4
BGC0002745	0.68	Polyketide	verrucosidin	Penicillium polonicum
BGC0002194	0.67	Polyketide	epipyrone A	Epicoccum nigrum
BGC0001254	0.67	Polyketide	ACT-Toxin II	Alternaria alternata
BGC0001400	0.67	Polyketide	citreoviridin	Aspergillus terreus NIH2624
BGC0002258	0.67	Polyketide	shimalactone A, shimalactone B	Aspergillus stellatus

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 45000:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-redmal) + (Me-pk)
Non-colinear ordering:: mkB + mkA

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 29615:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-redmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 11418 - 45000:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

mkB

PKS_AT (544..869): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 81.5
Methoxymalonyl-CoA: 57.8
Methylmalonyl-CoA: 57.3
Isobutyryl-CoA: 28.0
Propionyl-CoA: 26.3
Benzoyl-CoA: 16.1
inactive: 9.8
2-Methylbutyryl-CoA: 9.0
Ethylmalonyl-CoA: 7.3
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

mkA

PKS_AT (602..924): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; Methylmalonyl-CoA: 62.5%; Ethylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 73.7
Methoxymalonyl-CoA: 56.1
Ethylmalonyl-CoA: 54.8
Isobutyryl-CoA: 26.8
Propionyl-CoA: 25.7
Malonyl-CoA: 25.3
2-Methylbutyryl-CoA: 22.6
fatty_acid: 19.9
trans-1,2-CPDA: 18.2
Benzoyl-CoA: 14.8
CHC-CoA: 9.6
inactive: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0