BGC0000099 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000099 (Talaromyces marneffei (anamorph: Penicillium marneffei))

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	8,104	monascorubrin	PKS	100%

BGC0000099 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 8,104 nt. (total: 8,104 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 8,105
Label		BGC0000099

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000099	1.00	Polyketide	monascorubrin	Talaromyces marneffei
BGC0002429	0.24	Terpene, Polyketide	higginsianin B	Colletotrichum higginsianum IMI 349063
BGC0000027	0.22	Polyketide	ankaflavin, monascin, rubropunctatine, monascorubrin	Monascus pilosus
BGC0002427	0.22	Terpene, Polyketide	subglutinol A, subglutinol B	Metarhizium robertsii ARSEF 23
BGC0001338	0.22	Polyketide	citrinin	Monascus ruber
BGC0001976	0.21	Terpene	eupenifeldin	Phoma sp.
BGC0000154	0.21	Polyketide	stipitatic acid	Talaromyces stipitatus ATCC 10500
BGC0001257	0.20	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001827	0.20	Polyketide	xenovulene A	Sarocladium sp. 'schorii'
BGC0000037	0.19	Polyketide	cichorine	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000099	1.00	Polyketide	monascorubrin	Talaromyces marneffei
BGC0002429	0.57	Terpene, Polyketide	higginsianin B	Colletotrichum higginsianum IMI 349063
BGC0000027	0.55	Polyketide	ankaflavin, monascin, rubropunctatine, monascorubrin	Monascus pilosus
BGC0002427	0.55	Terpene, Polyketide	subglutinol A, subglutinol B	Metarhizium robertsii ARSEF 23
BGC0001338	0.54	Polyketide	citrinin	Monascus ruber
BGC0001976	0.54	Terpene	eupenifeldin	Phoma sp.
BGC0000154	0.53	Polyketide	stipitatic acid	Talaromyces stipitatus ATCC 10500
BGC0001257	0.52	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001827	0.52	Polyketide	xenovulene A	Sarocladium sp. 'schorii'
BGC0000037	0.51	Polyketide	cichorine	Aspergillus nidulans FGSC A4

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 8104:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ADH01663.1

PKS_AT (899..1191): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; Ethylmalonyl-CoA: 54.2%; Methylmalonyl-CoA: 54.2%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 60.2
Methylmalonyl-CoA: 56.3
Malonyl-CoA: 52.8
inactive: 51.9
Propionyl-CoA: 33.9
Ethylmalonyl-CoA: 32.4
CHC-CoA: 30.1
2-Methylbutyryl-CoA: 25.3
trans-1,2-CPDA: 21.4
fatty_acid: 20.0
Acetyl-CoA: 12.3
3-Methylbutyryl-CoA: 10.8
Benzoyl-CoA: 10.6
Isobutyryl-CoA: 9.3