BGC0000100 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000100 (Streptomyces virginiae)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	103,450	monensin	PKS	100%

BGC0000100 - Region 1 - T1PKS

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Location: 1 - 103,450 nt. (total: 103,450 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 103,451
Label		BGC0000100

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000100	1.00	Polyketide	monensin	Streptomyces cinnamonensis
BGC0001670	1.00	Polyketide	monensin	Streptomyces cinnamonensis
BGC0000016	0.39	Other	amphotericin B	Streptomyces nodosus
BGC0000084	0.35	Polyketide	laidlomycin	Streptomyces sp. CS684
BGC0001273	0.34	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001163	0.34	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001276	0.33	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244	0.33	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001275	0.33	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002266	0.32	Terpene, Polyketide	calidoustene A, calidoustene B, calidoustene C	Aspergillus calidoustus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000100	1.00	Polyketide	monensin	Streptomyces cinnamonensis
BGC0001670	1.00	Polyketide	monensin	Streptomyces cinnamonensis
BGC0000016	0.71	Other	amphotericin B	Streptomyces nodosus
BGC0000084	0.68	Polyketide	laidlomycin	Streptomyces sp. CS684
BGC0001273	0.67	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001163	0.67	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001276	0.67	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244	0.66	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001275	0.66	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002266	0.65	Terpene, Polyketide	calidoustene A, calidoustene B, calidoustene C	Aspergillus calidoustus

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 103450:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-ccmal) + (Me-redmal) + (ccmal - Me-redmal) + (ccemal - redmal) + (Me-ccmal - redmal) + (ohmal) + (Me-ohmal) + (Me-ohmal - Me-ccmal)
Non-colinear ordering:: monAI + monAII + monAIII + monAIV + monAV + monAVI + monAVII + monAVIII

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

monAI

PKS_AT (553..877): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 91.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 187.6
inactive: 95.8
Methoxymalonyl-CoA: 64.0
Methylmalonyl-CoA: 50.6
Propionyl-CoA: 32.8
Acetyl-CoA: 31.1
Isobutyryl-CoA: 26.0
Ethylmalonyl-CoA: 21.0
Benzoyl-CoA: 10.2
3-Methylbutyryl-CoA: 10.0
trans-1,2-CPDA: 4.8
fatty_acid: 4.3
2-Methylbutyryl-CoA: 4.1
CHC-CoA: 0.1

PKS_AT (1616..1909): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 201.7
Ethylmalonyl-CoA: 193.1
Methoxymalonyl-CoA: 164.6
2-Methylbutyryl-CoA: 133.5
trans-1,2-CPDA: 122.6
Propionyl-CoA: 114.8
Malonyl-CoA: 99.2
CHC-CoA: 97.1
Isobutyryl-CoA: 70.9
Benzoyl-CoA: 59.3
Acetyl-CoA: 47.3
fatty_acid: 46.8
3-Methylbutyryl-CoA: 31.7
inactive: 26.3

monAII

PKS_AT (565..860): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 190.9
Ethylmalonyl-CoA: 188.6
Methoxymalonyl-CoA: 146.1
2-Methylbutyryl-CoA: 116.4
trans-1,2-CPDA: 112.5
Propionyl-CoA: 111.5
CHC-CoA: 110.3
Malonyl-CoA: 83.7
Isobutyryl-CoA: 66.0
fatty_acid: 42.6
Benzoyl-CoA: 41.7
Acetyl-CoA: 37.8
3-Methylbutyryl-CoA: 24.2
inactive: 18.7

monAIII

PKS_AT (609..912): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 227.9
inactive: 119.5
Methoxymalonyl-CoA: 64.9
Methylmalonyl-CoA: 58.8
Isobutyryl-CoA: 32.2
Propionyl-CoA: 30.0
Benzoyl-CoA: 21.5
Ethylmalonyl-CoA: 18.1
Acetyl-CoA: 18.1
2-Methylbutyryl-CoA: 15.9
CHC-CoA: 10.3
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2508..2803): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 191.0
Ethylmalonyl-CoA: 188.5
Methoxymalonyl-CoA: 145.6
2-Methylbutyryl-CoA: 116.8
trans-1,2-CPDA: 113.8
Propionyl-CoA: 111.9
CHC-CoA: 111.4
Malonyl-CoA: 81.9
Isobutyryl-CoA: 68.2
fatty_acid: 44.2
Benzoyl-CoA: 43.5
Acetyl-CoA: 39.6
3-Methylbutyryl-CoA: 25.5
inactive: 17.8

monAIV

PKS_AT (594..889): emal

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Methylmalonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 229.3
Methylmalonyl-CoA: 189.3
Methoxymalonyl-CoA: 157.9
2-Methylbutyryl-CoA: 118.8
trans-1,2-CPDA: 114.9
Malonyl-CoA: 112.8
Propionyl-CoA: 102.9
CHC-CoA: 96.8
Isobutyryl-CoA: 78.9
Benzoyl-CoA: 77.3
Acetyl-CoA: 57.1
fatty_acid: 40.3
inactive: 27.6
3-Methylbutyryl-CoA: 22.9

PKS_AT (2378..2672): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 195.3
inactive: 87.3
Methoxymalonyl-CoA: 83.8
Methylmalonyl-CoA: 74.0
Propionyl-CoA: 48.6
Isobutyryl-CoA: 44.7
Ethylmalonyl-CoA: 40.1
fatty_acid: 39.5
Acetyl-CoA: 30.4
trans-1,2-CPDA: 21.9
2-Methylbutyryl-CoA: 20.1
Benzoyl-CoA: 18.3
CHC-CoA: 15.4
3-Methylbutyryl-CoA: 0.0

monAV

PKS_AT (564..859): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 189.9
Ethylmalonyl-CoA: 189.6
Methoxymalonyl-CoA: 145.5
trans-1,2-CPDA: 113.7
2-Methylbutyryl-CoA: 111.5
Propionyl-CoA: 108.3
CHC-CoA: 105.4
Malonyl-CoA: 83.8
Isobutyryl-CoA: 63.7
Benzoyl-CoA: 45.8
fatty_acid: 39.5
Acetyl-CoA: 37.2
3-Methylbutyryl-CoA: 23.5
inactive: 18.2

PKS_AT (2399..2694): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.1
inactive: 97.7
Methoxymalonyl-CoA: 75.8
Methylmalonyl-CoA: 70.7
Propionyl-CoA: 44.8
Isobutyryl-CoA: 39.1
Ethylmalonyl-CoA: 36.7
Acetyl-CoA: 33.3
fatty_acid: 31.4
trans-1,2-CPDA: 20.5
Benzoyl-CoA: 17.2
CHC-CoA: 15.5
2-Methylbutyryl-CoA: 15.0
3-Methylbutyryl-CoA: 0.0

monAVI

PKS_AT (583..880): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 203.5
inactive: 99.1
Methoxymalonyl-CoA: 71.7
Methylmalonyl-CoA: 66.2
Propionyl-CoA: 45.3
Isobutyryl-CoA: 36.5
Ethylmalonyl-CoA: 33.8
Acetyl-CoA: 33.4
fatty_acid: 30.5
CHC-CoA: 18.4
trans-1,2-CPDA: 18.2
Benzoyl-CoA: 17.9
2-Methylbutyryl-CoA: 16.6
3-Methylbutyryl-CoA: 0.0

monAVIII

PKS_AT (564..862): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 192.4
Ethylmalonyl-CoA: 185.2
Methoxymalonyl-CoA: 152.8
2-Methylbutyryl-CoA: 124.3
Propionyl-CoA: 119.8
trans-1,2-CPDA: 119.0
CHC-CoA: 105.9
Malonyl-CoA: 89.5
Isobutyryl-CoA: 69.1
fatty_acid: 46.6
Benzoyl-CoA: 43.8
Acetyl-CoA: 38.5
3-Methylbutyryl-CoA: 26.4
inactive: 22.2

PKS_AT (2120..2415): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.7
Ethylmalonyl-CoA: 192.2
Methoxymalonyl-CoA: 150.6
2-Methylbutyryl-CoA: 125.9
CHC-CoA: 122.0
Propionyl-CoA: 118.6
trans-1,2-CPDA: 117.2
Malonyl-CoA: 93.2
Isobutyryl-CoA: 67.4
Benzoyl-CoA: 42.4
Acetyl-CoA: 41.7
fatty_acid: 40.2
3-Methylbutyryl-CoA: 34.1
inactive: 27.3

monAVII

PKS_AT (569..864): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 190.9
Ethylmalonyl-CoA: 188.6
Methoxymalonyl-CoA: 146.1
2-Methylbutyryl-CoA: 116.4
trans-1,2-CPDA: 112.5
Propionyl-CoA: 111.5
CHC-CoA: 110.3
Malonyl-CoA: 83.7
Isobutyryl-CoA: 66.0
fatty_acid: 42.6
Benzoyl-CoA: 41.7
Acetyl-CoA: 37.8
3-Methylbutyryl-CoA: 24.2
inactive: 18.7