BGC0000100: monensin biosynthetic gene cluster from Streptomyces cinnamonensis
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Location: 1 - 103,450 nt. (total: 103,450 nt).
This entry is originally from NCBI GenBank AF440781.1.

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core biosynthetic genes
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resistance
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Gene details
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General
Compounds
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Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000100
Short description monensin biosynthetic gene cluster from Streptomyces cinnamonensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
AF440781.1
via
Compounds
  • monensin
Species Streptomyces cinnamonensis [taxonomy]
References
Chemical products information
monensin Evidence:
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C36H62O11
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAO65782.1
  • gdhA
 1 - 1038 (-) glutamate dehydrogenase
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    • AAO65783.1
    • dapA
    		 1220 - 2140 (-) dihidro-dipicolinate synthase
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      • AAO65784.1
      		 2211 - 3152 (+) hypothetical DNA binding protein
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        • AAO65785.1
        		 3264 - 3680 (+) hypothetical protein
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          • AAO65786.1
          		 3684 - 4307 (-) hypothetical protein
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            • AAO65787.1
            		 4570 - 4758 (+) hypothetical protein
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              • AAO65788.1
              		 5058 - 5612 (+) hypothetical protein
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                • AAO65789.1
                		 5693 - 6010 (-) acyl carrier protein
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                  • AAO65790.1
                  		 6045 - 8531 (-) ketosynthase-like protein
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                    • AAO65791.1
                    • monCII
                    		 8643 - 9542 (-) monensin cyclase
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                      • AAO65792.1
                      • monE
                      		 9596 - 10426 (-) monensin 3-O-methyl transferase
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                        • AAO65793.1
                        • monT
                        		 10656 - 12191 (+) putative monensin resistance protein
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                          • AAO65794.1
                          • monRII
                          		 12205 - 12780 (+) putative monensin cluster negative regulator
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                            • AAO65795.1
                            • monAIX
                            		 13023 - 13829 (-) PKS thioesterase
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                              • AAO65796.1
                              • monAI
                              		 14121 - 23198 (+) monensin polyketide synthase loading module and module 1
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                                • AAO65797.1
                                • monAII
                                		 23205 - 29921 (+) monensin polyketide synthase module 2
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                                  • AAO65798.1
                                  • monAIII
                                  		 29974 - 42372 (+) monensin polyketide synthase modules 3 and 4
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                                    • AAO65799.1
                                    • monAIV
                                    		 42448 - 54564 (+) monensin polyketide synthase modules 5 and 6
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                                      • AAO65800.1
                                      • monAV
                                      		 54614 - 66934 (+) monensin polyketide synthase modules 7 and 8
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                                        • AAO65801.1
                                        • monAVI
                                        		 66952 - 72054 (+) monensin polyketide synthase module 9
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                                          • AAO65802.1
                                          • monH
                                          		 72051 - 74993 (+) putative regulatory protein
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                                            • AAO65803.1
                                            • monC1
                                            		 75051 - 76541 (-) monensin epoxidase
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                                              • AAO65804.1
                                              • monBII
                                              		 76538 - 76960 (-) probable monensin biosynthesis isomerase
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                                                • AAO65805.1
                                                • monBI
                                                		 77016 - 77450 (-) probable monensin biosynthesis isomerase
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                                                  • AAO65806.1
                                                  • monAVIII
                                                  		 77447 - 88708 (-) monensin polyketide synthase modules 11 and 12
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                                                    • AAO65807.1
                                                    • monAVII
                                                    		 88816 - 93741 (-) monensin polyketide synthase module 10
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                                                      • AAO65808.1
                                                      • monD
                                                      		 93981 - 95273 (+) monensin hydroxylase
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                                                        • AAO65809.1
                                                        • monRI
                                                        		 95338 - 96141 (-) activator protein
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                                                          • AAO65810.1
                                                          • monAX
                                                          		 96138 - 96941 (-) thioesterase
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                                                            • AAO65811.1
                                                            		 97580 - 98953 (+) unknown
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                                                              • AAO65812.1
                                                              		 98991 - 99983 (-) putative lipase
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                                                                • AAO65813.1
                                                                		 100507 - 101433 (-) hypothetical transport protein
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                                                                  • AAO65814.1
                                                                  		 101490 - 102581 (-) unknown
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                                                                    • AAO65815.1
                                                                    • amtA
                                                                    		 102924 - >103450 (+) glycine amidinotransferase
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                                                                      Biosynthesis information
                                                                      Annotation changelog

                                                                      Entry version: 4

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2022-10-07
                                                                      Update chemical activity to schema version 2.11
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                      Entry version: 3

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2022-09-15
                                                                      Updated bioactivity data
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                      Entry version: 2

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2019-10-16
                                                                      Migrated from v1.4
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      2019-10-16
                                                                      Updated compound(s) information (NPAtlas curation)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                      Entry version: 1

                                                                      Date
                                                                      Changes
                                                                      Submitters
                                                                      Reviewers
                                                                      2015-06-12
                                                                      Submitted
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                      Detailed domain annotation
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