BGC0000101: emodin biosynthetic gene cluster from Aspergillus nidulans FGSC A4
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Location: 4,367,684 - 4,413,245 nt. (total: 45,562 nt).
This entry is originally from NCBI GenBank BN001308.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000101
Short description emodin biosynthetic gene cluster from Aspergillus nidulans FGSC A4
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "In the presence of an out-of-cluster prenyltransferases, shamixanthone can be produced"
Biosynthetic class(es)
  • PKS (Iterative type I)
Loci
BN001308.1
4379755 - 4404005
via Knock-out studies, Enzymatic assays, Gene expression correlated with compound production
Compounds
  • emodin
  • monodictyphenone
  • shamixanthone
Species Aspergillus nidulans FGSC A4 [taxonomy]
References
Chemical products information
emodin Evidence:
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C15H10O5
Chemical database entries
PubCHEM
monodictyphenone Evidence:
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C15H12O6
Chemical database entries
NPAtlas
PubCHEM
shamixanthone Evidence:
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C25H26O5
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ANIA_10023
  • CBF90088.1
 4379755 - 4381095 (-) conserved hypothetical protein
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    • ANIA_10044
    • CBF90090.1
    		 4381456 - 4382253 (-) toxin biosynthesis protein, putative (AFU_orthologue; AFUA_4G14520)
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      • ANIA_10038
      • CBF90092.1
      		 4382618 - 4383416 (+) hypothetical protein
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        • ANIA_10035
        • CBF90094.1
        		 4383562 - 4385418 (-) conserved hypothetical protein
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          • ANIA_10022
          • CBF90095.1
          		 4385793 - 4387378 (-) conserved hypothetical protein
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            • ANIA_00150
            • CBF90097.1
            		 4387684 - 4393245 (-) hypothetical protein similar to polyketide synthase (Broad)
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              • ANIA_00149
              • CBF90099.1
              		 4393714 - 4394731 (+) metallo-beta-lactamase domain protein, putative (AFU_orthologue; AFUA_4G14570)
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                • ANIA_00148
                • CBF90101.1
                		 4396210 - 4397517 (+) Putative Zn(II)2Cys6 transcription factor (Eurofung)
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                  • ANIA_00147
                  • CBF90103.1
                  		 4398044 - 4399687 (+) conserved hypothetical protein
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                    • ANIA_00146
                    • CBF90105.1
                    		 4400318 - 4401170 (+) oxidoreductase, putative (Eurofung)
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                      • ANIA_10049
                      • CBF90107.1
                      		 4401466 - 4402157 (+) conidial pigment biosynthesis scytalone dehydratase (Eurofung)
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                        • ANIA_10021
                        • CBF90109.1
                        		 4402496 - 4404005 (+) toxin biosynthesis regulatory protein AflJ, putative (AFU_orthologue; AFUA_4G14550)
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                          Biosynthesis information

                          Biosynthetic modules

                          Name
                          1
                          Type
                          pks-modular
                          Genes
                          ANIA_00150
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, ketosynthase, acyltransferase, product_template, carrier (ACP), carrier (ACP)
                          Annotation changelog

                          Entry version: 5

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2024-10-10
                          Unretire entry, as two of the three named compounds are produced by these genes
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 4

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-10-07
                            Update chemical activity to schema version 2.11
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 3

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Corrected loci
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Removed thioesterase with unknown gene ID
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Retired due to involving multiple contigs
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2019-10-16
                            Migrated from v1.4
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2019-10-16
                            Updated compound(s) information (NPAtlas curation)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2015-06-12
                            Submitted
                            • (ID: J4R6BDENZAM7XVDGVEEHZB2Y)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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