BGC0000102 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000102 (Micromonospora griseorubida)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	58,343	mycinamicin II	PKS	100%

BGC0000102 - Region 1 - T1PKS

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Location: 1 - 58,343 nt. (total: 58,343 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 58,344
Label		BGC0000102

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000102	1.00	Polyketide	mycinamicin II	Micromonospora griseorubida
BGC0000018	0.48	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000041	0.35	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002435	0.35	Other	coformycin, aristeromycin	Micromonospora haikouensis
BGC0001273	0.33	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000166	0.33	Polyketide	tylactone	Streptomyces fradiae
BGC0001275	0.33	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244	0.33	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0000170	0.32	Polyketide	yanuthone D	Aspergillus niger ATCC 1015
BGC0002615	0.31	Terpene	4-oxomacrophorin A, macrophorin A, 5'-epimacrophorin B	Penicillium terrestre

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000102	1.00	Polyketide	mycinamicin II	Micromonospora griseorubida
BGC0000018	0.78	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000041	0.68	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002435	0.68	Other	coformycin, aristeromycin	Micromonospora haikouensis
BGC0001273	0.67	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000166	0.66	Polyketide	tylactone	Streptomyces fradiae
BGC0001275	0.66	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244	0.66	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0000170	0.65	Polyketide	yanuthone D	Aspergillus niger ATCC 1015
BGC0002615	0.65	Terpene	4-oxomacrophorin A, macrophorin A, 5'-epimacrophorin B	Penicillium terrestre

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 58343:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk - Me-ohmal - ccmal) + (ccmal) + (Me-ccmal - Me-redmal) + (Me-ohmal) + (ccmal)
Non-colinear ordering:: mycAI + mycAII + mycAIII + mycAIV + mycAV

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

mycAI

PKS_AT (507..806): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 208.3
Methylmalonyl-CoA: 208.2
Methoxymalonyl-CoA: 163.7
2-Methylbutyryl-CoA: 130.6
trans-1,2-CPDA: 122.9
Propionyl-CoA: 94.7
Malonyl-CoA: 91.0
Isobutyryl-CoA: 87.0
CHC-CoA: 85.5
Benzoyl-CoA: 70.3
Acetyl-CoA: 48.8
fatty_acid: 27.7
inactive: 21.6
3-Methylbutyryl-CoA: 16.8

PKS_AT (1530..1817): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 79.2%; Malonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 168.2
Ethylmalonyl-CoA: 134.0
Methoxymalonyl-CoA: 117.9
2-Methylbutyryl-CoA: 91.5
trans-1,2-CPDA: 86.3
CHC-CoA: 82.3
Propionyl-CoA: 71.8
Malonyl-CoA: 53.3
Isobutyryl-CoA: 41.8
Benzoyl-CoA: 25.0
fatty_acid: 23.4
Acetyl-CoA: 21.4
3-Methylbutyryl-CoA: 20.1
inactive: 0.0

PKS_AT (3006..3306): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.0
inactive: 107.7
Methoxymalonyl-CoA: 68.4
Methylmalonyl-CoA: 65.6
Propionyl-CoA: 45.7
Isobutyryl-CoA: 25.3
Ethylmalonyl-CoA: 22.6
2-Methylbutyryl-CoA: 21.8
CHC-CoA: 18.7
Acetyl-CoA: 17.8
fatty_acid: 15.3
Benzoyl-CoA: 13.6
trans-1,2-CPDA: 13.1
3-Methylbutyryl-CoA: 4.9

mycAII

PKS_AT (574..869): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 195.0
inactive: 92.8
Methoxymalonyl-CoA: 73.4
Methylmalonyl-CoA: 64.7
Isobutyryl-CoA: 37.3
Ethylmalonyl-CoA: 31.2
Propionyl-CoA: 30.2
Acetyl-CoA: 22.0
2-Methylbutyryl-CoA: 21.7
CHC-CoA: 19.9
Benzoyl-CoA: 19.2
trans-1,2-CPDA: 11.8
fatty_acid: 11.1
3-Methylbutyryl-CoA: 0.0

mycAIII

PKS_AT (592..892): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 79.2%; Malonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 175.9
Ethylmalonyl-CoA: 151.5
Methoxymalonyl-CoA: 129.8
CHC-CoA: 98.3
2-Methylbutyryl-CoA: 89.3
trans-1,2-CPDA: 88.4
Propionyl-CoA: 77.6
Malonyl-CoA: 58.3
Isobutyryl-CoA: 46.6
Benzoyl-CoA: 37.0
3-Methylbutyryl-CoA: 28.9
Acetyl-CoA: 28.0
fatty_acid: 25.0
inactive: 9.4

PKS_AT (2037..2337): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 79.2%; Malonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 174.0
Ethylmalonyl-CoA: 146.4
Methoxymalonyl-CoA: 128.5
CHC-CoA: 96.6
2-Methylbutyryl-CoA: 87.5
trans-1,2-CPDA: 87.4
Propionyl-CoA: 77.1
Malonyl-CoA: 63.0
Isobutyryl-CoA: 44.5
Benzoyl-CoA: 32.8
3-Methylbutyryl-CoA: 29.3
fatty_acid: 26.3
Acetyl-CoA: 21.5
inactive: 0.0

mycAIV

PKS_AT (579..880): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 79.2%; Malonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 168.4
Ethylmalonyl-CoA: 139.3
Methoxymalonyl-CoA: 124.3
CHC-CoA: 88.3
trans-1,2-CPDA: 87.1
2-Methylbutyryl-CoA: 86.9
Propionyl-CoA: 78.4
Malonyl-CoA: 61.3
Isobutyryl-CoA: 43.8
Benzoyl-CoA: 28.9
Acetyl-CoA: 28.0
fatty_acid: 25.3
3-Methylbutyryl-CoA: 22.7
inactive: 10.7

mycAV

PKS_AT (570..869): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 206.8
inactive: 104.2
Methoxymalonyl-CoA: 69.3
Methylmalonyl-CoA: 60.0
Propionyl-CoA: 40.2
2-Methylbutyryl-CoA: 22.5
Ethylmalonyl-CoA: 21.8
Acetyl-CoA: 18.8
CHC-CoA: 14.3
Benzoyl-CoA: 13.9
Isobutyryl-CoA: 11.1
fatty_acid: 10.7
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0