BGC0000103 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000103 (Mycobacterium ulcerans Agy99)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	107,218	mycolactone B	PKS	100%

BGC0000103 - Region 1 - T1PKS

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Location: 1 - 107,218 nt. (total: 107,218 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 107,219
Label		BGC0000103

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000103	1.00	Polyketide	mycolactone B	Mycobacterium ulcerans Agy99
BGC0001276	0.33	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0000353	0.25	NRP	tacrolimus	Streptomyces sp. MA6548
BGC0000067	0.23	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000041	0.22	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001273	0.21	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000160	0.21	Polyketide	terreic acid	Aspergillus terreus NIH2624
BGC0001244	0.21	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001161	0.21	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0001162	0.21	Polyketide	1-heptadecene	Moorea producens JHB

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000103	1.00	Polyketide	mycolactone B	Mycobacterium ulcerans Agy99
BGC0001276	0.66	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0000353	0.59	NRP	tacrolimus	Streptomyces sp. MA6548
BGC0000067	0.56	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000041	0.55	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001273	0.54	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000160	0.54	Polyketide	terreic acid	Aspergillus terreus NIH2624
BGC0001244	0.53	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001161	0.53	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0001162	0.53	Polyketide	1-heptadecene	Moorea producens JHB

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 107218:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ccmal - ohmal - ohmal - Me-ccmal - ccmal - Me-ccmal - Me-ccmal - ccmal) + (ccmal - ccmal - Me-redmal - Me-ccmal - Me-redmal - ohmal - Me-ccmal - Me-redmal - ccmal) + (redmal)
Non-colinear ordering:: MUP032c + MUP040c + MUP039c

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

MUP032c

PKS_AT (568..868): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 177.4
inactive: 95.1
Methoxymalonyl-CoA: 81.1
Methylmalonyl-CoA: 69.7
Propionyl-CoA: 54.7
CHC-CoA: 25.7
2-Methylbutyryl-CoA: 25.4
Ethylmalonyl-CoA: 24.3
trans-1,2-CPDA: 14.9
Isobutyryl-CoA: 14.9
Acetyl-CoA: 13.1
fatty_acid: 8.7
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2360..2649): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 184.7
inactive: 99.1
Methoxymalonyl-CoA: 73.7
Methylmalonyl-CoA: 60.0
Propionyl-CoA: 32.8
Ethylmalonyl-CoA: 30.7
fatty_acid: 27.8
Acetyl-CoA: 27.8
Benzoyl-CoA: 27.2
Isobutyryl-CoA: 24.4
2-Methylbutyryl-CoA: 22.8
CHC-CoA: 20.2
trans-1,2-CPDA: 18.4
3-Methylbutyryl-CoA: 0.0

PKS_AT (3899..4188): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 184.7
inactive: 99.1
Methoxymalonyl-CoA: 73.7
Methylmalonyl-CoA: 60.0
Propionyl-CoA: 32.8
Ethylmalonyl-CoA: 30.7
fatty_acid: 27.8
Acetyl-CoA: 27.8
Benzoyl-CoA: 27.2
Isobutyryl-CoA: 24.4
2-Methylbutyryl-CoA: 22.8
CHC-CoA: 20.2
trans-1,2-CPDA: 18.4
3-Methylbutyryl-CoA: 0.0

PKS_AT (5445..5745): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.6
Ethylmalonyl-CoA: 191.2
Methoxymalonyl-CoA: 172.8
2-Methylbutyryl-CoA: 134.1
trans-1,2-CPDA: 109.6
Malonyl-CoA: 105.4
Propionyl-CoA: 104.8
CHC-CoA: 92.9
Isobutyryl-CoA: 71.4
Acetyl-CoA: 66.1
3-Methylbutyryl-CoA: 57.6
Benzoyl-CoA: 48.8
inactive: 40.2
fatty_acid: 23.8

PKS_AT (7244..7544): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 177.4
inactive: 95.1
Methoxymalonyl-CoA: 81.1
Methylmalonyl-CoA: 69.7
Propionyl-CoA: 54.7
CHC-CoA: 25.7
2-Methylbutyryl-CoA: 25.4
Ethylmalonyl-CoA: 24.3
trans-1,2-CPDA: 14.9
Isobutyryl-CoA: 14.9
Acetyl-CoA: 13.1
fatty_acid: 8.7
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (9043..9343): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.6
Ethylmalonyl-CoA: 191.2
Methoxymalonyl-CoA: 172.8
2-Methylbutyryl-CoA: 134.1
trans-1,2-CPDA: 109.6
Malonyl-CoA: 105.4
Propionyl-CoA: 104.8
CHC-CoA: 92.9
Isobutyryl-CoA: 71.4
Acetyl-CoA: 66.1
3-Methylbutyryl-CoA: 57.6
Benzoyl-CoA: 48.8
inactive: 40.2
fatty_acid: 23.8

PKS_AT (10842..11142): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.6
Ethylmalonyl-CoA: 191.2
Methoxymalonyl-CoA: 172.8
2-Methylbutyryl-CoA: 134.1
trans-1,2-CPDA: 109.6
Malonyl-CoA: 105.4
Propionyl-CoA: 104.8
CHC-CoA: 92.9
Isobutyryl-CoA: 71.4
Acetyl-CoA: 66.1
3-Methylbutyryl-CoA: 57.6
Benzoyl-CoA: 48.8
inactive: 40.2
fatty_acid: 23.8

PKS_AT (12641..12941): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 177.4
inactive: 95.1
Methoxymalonyl-CoA: 81.1
Methylmalonyl-CoA: 69.7
Propionyl-CoA: 54.7
CHC-CoA: 25.7
2-Methylbutyryl-CoA: 25.4
Ethylmalonyl-CoA: 24.3
trans-1,2-CPDA: 14.9
Isobutyryl-CoA: 14.9
Acetyl-CoA: 13.1
fatty_acid: 8.7
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

MUP039c

PKS_AT (591..891): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 177.4
inactive: 95.1
Methoxymalonyl-CoA: 81.1
Methylmalonyl-CoA: 69.7
Propionyl-CoA: 54.7
CHC-CoA: 25.7
2-Methylbutyryl-CoA: 25.4
Ethylmalonyl-CoA: 24.3
trans-1,2-CPDA: 14.9
Isobutyryl-CoA: 14.9
Acetyl-CoA: 13.1
fatty_acid: 8.7
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

MUP040c

PKS_AT (568..868): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 177.4
inactive: 95.1
Methoxymalonyl-CoA: 81.1
Methylmalonyl-CoA: 69.7
Propionyl-CoA: 54.7
CHC-CoA: 25.7
2-Methylbutyryl-CoA: 25.4
Ethylmalonyl-CoA: 24.3
trans-1,2-CPDA: 14.9
Isobutyryl-CoA: 14.9
Acetyl-CoA: 13.1
fatty_acid: 8.7
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2373..2673): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 177.4
inactive: 95.1
Methoxymalonyl-CoA: 81.1
Methylmalonyl-CoA: 69.7
Propionyl-CoA: 54.7
CHC-CoA: 25.7
2-Methylbutyryl-CoA: 25.4
Ethylmalonyl-CoA: 24.3
trans-1,2-CPDA: 14.9
Isobutyryl-CoA: 14.9
Acetyl-CoA: 13.1
fatty_acid: 8.7
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (4178..4478): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.6
Ethylmalonyl-CoA: 191.2
Methoxymalonyl-CoA: 172.8
2-Methylbutyryl-CoA: 134.1
trans-1,2-CPDA: 109.6
Malonyl-CoA: 105.4
Propionyl-CoA: 104.8
CHC-CoA: 92.9
Isobutyryl-CoA: 71.4
Acetyl-CoA: 66.1
3-Methylbutyryl-CoA: 57.6
Benzoyl-CoA: 48.8
inactive: 40.2
fatty_acid: 23.8

PKS_AT (6299..6599): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.6
Ethylmalonyl-CoA: 191.2
Methoxymalonyl-CoA: 172.8
2-Methylbutyryl-CoA: 134.1
trans-1,2-CPDA: 109.6
Malonyl-CoA: 105.4
Propionyl-CoA: 104.8
CHC-CoA: 92.9
Isobutyryl-CoA: 71.4
Acetyl-CoA: 66.1
3-Methylbutyryl-CoA: 57.6
Benzoyl-CoA: 48.8
inactive: 40.2
fatty_acid: 23.8

PKS_AT (8097..8397): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.6
Ethylmalonyl-CoA: 191.2
Methoxymalonyl-CoA: 172.8
2-Methylbutyryl-CoA: 134.1
trans-1,2-CPDA: 109.6
Malonyl-CoA: 105.4
Propionyl-CoA: 104.8
CHC-CoA: 92.9
Isobutyryl-CoA: 71.4
Acetyl-CoA: 66.1
3-Methylbutyryl-CoA: 57.6
Benzoyl-CoA: 48.8
inactive: 40.2
fatty_acid: 23.8

PKS_AT (10205..10494): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 184.7
inactive: 99.1
Methoxymalonyl-CoA: 73.7
Methylmalonyl-CoA: 60.0
Propionyl-CoA: 32.8
Ethylmalonyl-CoA: 30.7
fatty_acid: 27.8
Acetyl-CoA: 27.8
Benzoyl-CoA: 27.2
Isobutyryl-CoA: 24.4
2-Methylbutyryl-CoA: 22.8
CHC-CoA: 20.2
trans-1,2-CPDA: 18.4
3-Methylbutyryl-CoA: 0.0

PKS_AT (11751..12051): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.6
Ethylmalonyl-CoA: 191.2
Methoxymalonyl-CoA: 172.8
2-Methylbutyryl-CoA: 134.1
trans-1,2-CPDA: 109.6
Malonyl-CoA: 105.4
Propionyl-CoA: 104.8
CHC-CoA: 92.9
Isobutyryl-CoA: 71.4
Acetyl-CoA: 66.1
3-Methylbutyryl-CoA: 57.6
Benzoyl-CoA: 48.8
inactive: 40.2
fatty_acid: 23.8

PKS_AT (13544..13844): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.6
Ethylmalonyl-CoA: 191.2
Methoxymalonyl-CoA: 172.8
2-Methylbutyryl-CoA: 134.1
trans-1,2-CPDA: 109.6
Malonyl-CoA: 105.4
Propionyl-CoA: 104.8
CHC-CoA: 92.9
Isobutyryl-CoA: 71.4
Acetyl-CoA: 66.1
3-Methylbutyryl-CoA: 57.6
Benzoyl-CoA: 48.8
inactive: 40.2
fatty_acid: 23.8

PKS_AT (15664..15964): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 177.4
inactive: 95.1
Methoxymalonyl-CoA: 81.1
Methylmalonyl-CoA: 69.7
Propionyl-CoA: 54.7
CHC-CoA: 25.7
2-Methylbutyryl-CoA: 25.4
Ethylmalonyl-CoA: 24.3
trans-1,2-CPDA: 14.9
Isobutyryl-CoA: 14.9
Acetyl-CoA: 13.1
fatty_acid: 8.7
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0