BGC0000104 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000104 (Penicillium brevicompactum)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	33,515	High	mycophenolic acid	PKS:Type I

BGC0000104 - Region 1 - T1PKS

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Location: 1 - 33,515 nt. (total: 33,515 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 33,516
Label		BGC0000104

Tailoring functions

Oxidoreductases: oxygenase

mpaD: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Transferases: methyltransferase

mpaG: Methylation

MITE: MITE0000011Methylation (identity: 100.00%)
smcogs: SMCOG1042: O-methyltransferase

Ligases: synthase

mpaC: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000104.4	1.00	PKS	mycophenolic acid	Penicillium brevicompactum
BGC0002619.2	0.82	PKS	mycophenolic acid	Penicillium brevicompactum
BGC0001677.3	0.80	PKS	mycophenolic acid	Penicillium roqueforti
BGC0002616.2	0.80	PKS	mycophenolic acid	Penicillium roqueforti
BGC0001360.3	0.78	PKS	mycophenolic acid	Penicillium roqueforti FM164
BGC0000037.4	0.67	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.63	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000104.4	1.00	PKS	mycophenolic acid	Penicillium brevicompactum
BGC0002619.2	0.82	PKS	mycophenolic acid	Penicillium brevicompactum
BGC0001677.3	0.80	PKS	mycophenolic acid	Penicillium roqueforti
BGC0002616.2	0.80	PKS	mycophenolic acid	Penicillium roqueforti
BGC0001360.3	0.78	PKS	mycophenolic acid	Penicillium roqueforti FM164
BGC0000037.4	0.67	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.63	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 33515:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

mpaC: mal

PKS_AT (885..1175): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 59.3
inactive: 53.7
Methoxymalonyl-CoA: 39.5
Methylmalonyl-CoA: 32.0
fatty_acid: 14.5
Propionyl-CoA: 13.6
Ethylmalonyl-CoA: 12.5
Benzoyl-CoA: 11.5
2-Methylbutyryl-CoA: 10.7
CHC-CoA: 10.1
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor