Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000104.1:
Cluster 1Polyketide / Terpene125486

BGC0000104, mycophenolic acid biosynthetic gene cluster from Penicillium brevicompactum. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: mycophenolic acid
PubChem ID: 446541
ChEBI ID: 168396
ChEMBL ID: 866
ChemSpider ID: 393865
SMILES string: Copy to clipboard
Molecular formula: C17H20O6
Average molecular mass: 320.341 Da
Molecular activity: Inhibitor
Molecular target: inosine monophosphate dehydrogenase

Class-specific details

Biosynthetic class(es):
Polyketide / Terpene
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Iterative type I
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
ADY00130.1
Iterative PKS subtype:
Non-reducing
Number of iterations:
3
C2-C7 first
Thioesterase type:
Unknown
Release / cyclization type:
Hydrolysis

Terpene subclass:
Dolichol
Terpene subclass by size:
Sesquiterpene
Final isoprenoid precursor:
Other
Terpene synthase/cyclase-encoding genes:
Prenyltransferase-encoding genes:
ADY00128.1

Gene cluster description

mycophenolic acid (BGC0000104). Gene Cluster 1. Biosynthetic class = Polyketide/Terpene. GenBank HQ731031. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Jens Nielsen (Chalmers University of Technology)

Literature references

1. Regueira TB et al. (2011) Molecular basis for mycophenolic acid biosynthesis in Penicillium brevicompactum. Appl Environ Microbiol 77(9):3035-43. doi: 10.1128/AEM.03015-10. Epub
2. Smith CM et al. (1974) Inhibitors of inosinate dehydrogenase activity in Ehrlich ascites tumor cells in vitro. Biochem Pharmacol 23(19):2727-35.