BGC0000106 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000106 (Streptomyces sp. CS)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS,NRPS-like	1	106,181	High	naphthomycin A	PKS

BGC0000106 - Region 1 - NRPS-like,T1PKS

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Location: 1 - 106,181 nt. (total: 106,181 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 106,182
Label		BGC0000106

Tailoring functions

Oxidoreductases: oxidoreductase oxygenase

ADM46355.1: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

nat2: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

natL: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Transferases: acetyltransferase aminotransferase halogenase

nat1: flavin-dependent cycline orsellinic halogenase

halogenases: flavin-dependent cycline orsellinic halogenase
smcogs: SMCOG1119: halogenase

natE: acetyl-CoA acetyltransferase

smcogs: SMCOG1124: acetyl-CoA acetyltransferase

natK: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Hydrolases: esterase hydrolase

nat5: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

natM: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

natR: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: synthase

natA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

natB: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

natC: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

natD: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

natG: 3-dehydroquinate synthase

smcogs: SMCOG1183: 3-dehydroquinate synthase

Translocases: permease

nat9: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000106.5	1.34	PKS	naphthomycin A	Streptomyces sp. CS
BGC0001273.3	0.90	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.90	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.89	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000041.3	0.58	PKS	oronofacic acid	Pseudomonas syringae
BGC0002341.2	0.47	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002099.3	0.46	ribosomal	biarylitide YFH	Planomonospora sp. ID107089
BGC0001275.3	0.45	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000067.5	0.44	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001051.5	0.43	NRPS, PKS	thuggacin A	Sorangium cellulosum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000106.5	1.00	PKS	naphthomycin A	Streptomyces sp. CS
BGC0002341.2	0.77	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.75	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.75	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.75	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002192.3	0.64	PKS	FR901512	fungal sp. No.14919
BGC0001268.4	0.62	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0000041.3	0.60	PKS	oronofacic acid	Pseudomonas syringae

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 101365:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (AHBA - Me-ccmal - mal - Me-ohmal) + (Me-ccmal - Me-ccmal - ccmal) + (ccmal - Me-ccmal - ccmal) + (Me-ccmal - ccmal) + (ccmal - Me-ccmal)
Non-colinear ordering:: natA + natB + natC + natD + natE

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

natA: AHBA - mmal - mal - mmal

CAL_domain (33..442): AHBA

minowa: AHBA

Prediction, score:

AHBA: 442.0
shikimic_acid: 222.5
Acetyl-CoA: 16.8
fatty_acid: 0.0
NH2: 0.0

PKS_AT (1590..1888): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.4
Ethylmalonyl-CoA: 207.5
Methoxymalonyl-CoA: 168.3
2-Methylbutyryl-CoA: 112.4
trans-1,2-CPDA: 109.6
Propionyl-CoA: 100.3
CHC-CoA: 96.5
Malonyl-CoA: 88.5
Isobutyryl-CoA: 83.3
Benzoyl-CoA: 64.5
Acetyl-CoA: 44.5
fatty_acid: 42.6
3-Methylbutyryl-CoA: 34.3
inactive: 13.9

PKS_AT (3309..3609): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 83.3%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 202.9
inactive: 104.6
Methoxymalonyl-CoA: 74.0
Methylmalonyl-CoA: 55.0
Isobutyryl-CoA: 37.6
Propionyl-CoA: 33.3
Benzoyl-CoA: 26.4
CHC-CoA: 14.3
Acetyl-CoA: 14.0
trans-1,2-CPDA: 7.7
2-Methylbutyryl-CoA: 6.8
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -3.2

PKS_AT (4618..4920): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 207.4
Ethylmalonyl-CoA: 204.5
Methoxymalonyl-CoA: 166.6
2-Methylbutyryl-CoA: 116.6
trans-1,2-CPDA: 107.2
Propionyl-CoA: 104.4
Malonyl-CoA: 95.2
Isobutyryl-CoA: 89.4
CHC-CoA: 87.0
Benzoyl-CoA: 68.7
Acetyl-CoA: 44.2
fatty_acid: 31.8
3-Methylbutyryl-CoA: 30.0
inactive: 17.9

natB: mmal - mmal - mal

PKS_AT (568..865): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 203.8
Ethylmalonyl-CoA: 193.3
Methoxymalonyl-CoA: 167.6
2-Methylbutyryl-CoA: 114.4
trans-1,2-CPDA: 113.4
Propionyl-CoA: 102.2
Malonyl-CoA: 97.8
CHC-CoA: 91.6
Isobutyryl-CoA: 85.4
Benzoyl-CoA: 62.1
Acetyl-CoA: 41.8
fatty_acid: 31.0
3-Methylbutyryl-CoA: 23.0
inactive: 18.0

PKS_AT (2313..2611): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.4
Ethylmalonyl-CoA: 207.5
Methoxymalonyl-CoA: 168.3
2-Methylbutyryl-CoA: 112.4
trans-1,2-CPDA: 109.6
Propionyl-CoA: 100.3
CHC-CoA: 96.5
Malonyl-CoA: 88.5
Isobutyryl-CoA: 83.3
Benzoyl-CoA: 64.5
Acetyl-CoA: 44.5
fatty_acid: 42.6
3-Methylbutyryl-CoA: 34.3
inactive: 13.9

PKS_AT (4064..4358): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 195.6
inactive: 118.1
Methoxymalonyl-CoA: 59.6
Methylmalonyl-CoA: 50.1
Acetyl-CoA: 26.9
Propionyl-CoA: 23.0
Ethylmalonyl-CoA: 23.0
fatty_acid: 18.5
Isobutyryl-CoA: 17.3
Benzoyl-CoA: 11.8
trans-1,2-CPDA: 9.1
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

natC: mal - mmal - mal

PKS_AT (557..844): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 197.1
inactive: 112.6
Methoxymalonyl-CoA: 59.8
Methylmalonyl-CoA: 48.9
Acetyl-CoA: 26.9
Ethylmalonyl-CoA: 21.3
fatty_acid: 18.6
Propionyl-CoA: 18.2
Isobutyryl-CoA: 17.1
Benzoyl-CoA: 13.3
trans-1,2-CPDA: 9.8
CHC-CoA: 6.7
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2303..2601): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.4
Ethylmalonyl-CoA: 206.0
Methoxymalonyl-CoA: 166.6
2-Methylbutyryl-CoA: 112.6
trans-1,2-CPDA: 112.1
Propionyl-CoA: 102.6
CHC-CoA: 92.0
Malonyl-CoA: 88.3
Isobutyryl-CoA: 88.1
Benzoyl-CoA: 63.5
Acetyl-CoA: 41.1
fatty_acid: 37.8
3-Methylbutyryl-CoA: 29.9
inactive: 14.4

PKS_AT (4068..4355): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.5
inactive: 115.9
Methoxymalonyl-CoA: 60.5
Methylmalonyl-CoA: 48.9
Acetyl-CoA: 26.9
Ethylmalonyl-CoA: 22.9
Isobutyryl-CoA: 18.3
Propionyl-CoA: 17.8
fatty_acid: 15.4
Benzoyl-CoA: 13.7
trans-1,2-CPDA: 9.7
CHC-CoA: 6.6
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

natD: mmal - mal

PKS_AT (559..855): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.7
Ethylmalonyl-CoA: 206.4
Methoxymalonyl-CoA: 167.4
2-Methylbutyryl-CoA: 113.5
trans-1,2-CPDA: 112.2
Propionyl-CoA: 102.4
CHC-CoA: 91.7
Malonyl-CoA: 89.5
Isobutyryl-CoA: 89.0
Benzoyl-CoA: 63.3
Acetyl-CoA: 42.0
fatty_acid: 34.6
3-Methylbutyryl-CoA: 30.2
inactive: 13.9

PKS_AT (2343..2629): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 199.4
inactive: 123.5
Methoxymalonyl-CoA: 58.6
Methylmalonyl-CoA: 47.9
Acetyl-CoA: 24.7
Ethylmalonyl-CoA: 21.5
Isobutyryl-CoA: 19.7
fatty_acid: 18.1
Propionyl-CoA: 16.5
Benzoyl-CoA: 12.2
CHC-CoA: 5.3
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

natE: mal - mmal

PKS_AT (561..848): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 200.4
inactive: 123.6
Methoxymalonyl-CoA: 61.4
Methylmalonyl-CoA: 52.7
Acetyl-CoA: 26.8
Propionyl-CoA: 20.7
fatty_acid: 19.7
Isobutyryl-CoA: 18.2
Ethylmalonyl-CoA: 16.8
Benzoyl-CoA: 12.6
trans-1,2-CPDA: 8.6
CHC-CoA: 8.4
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2314..2611): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.4
Ethylmalonyl-CoA: 192.6
Methoxymalonyl-CoA: 164.5
2-Methylbutyryl-CoA: 121.9
trans-1,2-CPDA: 94.7
Propionyl-CoA: 93.8
Malonyl-CoA: 91.8
CHC-CoA: 83.8
Isobutyryl-CoA: 77.3
Benzoyl-CoA: 52.9
Acetyl-CoA: 37.9
3-Methylbutyryl-CoA: 24.8
fatty_acid: 21.5
inactive: 13.0

Link to PARAS substrate predictor