BGC0000106: naphthomycin A biosynthetic gene cluster from Streptomyces sp. CS
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Location: 1 - 106,181 nt. (total: 106,181 nt).
This entry is originally from NCBI GenBank GQ452266.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000106
Short description naphthomycin A biosynthetic gene cluster from Streptomyces sp. CS
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
GQ452266.1
via Knock-out studies
Compounds
  • naphthomycin A
Species Streptomyces sp. CS [taxonomy]
References
Chemical products information
naphthomycin A Evidence:
Copy SMILES
C40H46Cl1N1O9
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADM46349.1
 <5 - 1730 (+) ATP/GTP-binding protein
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    • ADM46350.1
    		 1897 - 4032 (+) ATP/GTP-binding protein
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      • ADM46351.1
      		 4107 - 4250 (-) hypothetical protein
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        • ADM46352.1
        		 4714 - 5007 (-) protoporphyrinogen oxidase
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          • ADM46353.1
          		 6855 - 8072 (+) transcriptional regulator
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            • ADM46354.1
            		 8300 - 8935 (+) acyl carrier protein phosphodiesterase
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              • ADM46355.1
              		 9033 - 10226 (+) cytochrome P450-like protein
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                • ADM46356.1
                • natA
                		 10604 - 27700 (+) polyketide synthase
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                  • ADM46357.1
                  • natB
                  		 27735 - 43754 (+) polyketide synthase
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                    • ADM46358.1
                    • natC
                    		 43801 - 59766 (+) polyketide synthase
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                      • ADM46359.1
                      • natD
                      		 59868 - 70733 (+) polyketide synthase
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                        • ADM46360.1
                        • natE
                        		 70764 - 81365 (+) polyketide synthase
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                          • ADM46361.1
                          • natF
                          		 81409 - 82278 (+) amide synthase
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                            • ADM46362.1
                            • nat1
                            		 82335 - 83678 (+) halogenase
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                              • ADM46363.1
                              • natG
                              		 83802 - 84863 (+) 3-dehydroquinate synthase
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                                • ADM46364.1
                                • natH
                                		 84896 - 86332 (+) DAHP synthase
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                                  • ADM46365.1
                                  • natI
                                  		 86329 - 87174 (+) shikimate/quinate dehydrogenase
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                                    • ADM46366.1
                                    • natK
                                    		 87338 - 88498 (+) 3-amino-5-hydroxybenzoic acid synthase
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                                      • ADM46367.1
                                      • natL
                                      		 88495 - 89589 (+) oxidoreductase
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                                        • ADM46368.1
                                        • natM
                                        		 89597 - 90292 (+) phosphatase
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                                          • ADM46369.1
                                          • natN
                                          		 90295 - 91215 (+) glucose kinase
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                                            • ADM46370.1
                                            • nat2
                                            		 91304 - 93061 (-) FAD-dependent oxidoreductase
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                                              • ADM46371.1
                                              • natR
                                              		 93194 - 93967 (+) thioesterase
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                                                • ADM46372.1
                                                • nat4
                                                		 94001 - 95386 (+) membrane ion antiporter
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                                                  • ADM46373.1
                                                  • natJ
                                                  		 95383 - 95823 (+) aminodehydroquinate dehydratase
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                                                    • ADM46374.1
                                                    • nat5
                                                    		 95894 - 96586 (+) putative alpha/beta fold family protein
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                                                      • ADM46375.1
                                                      • nat6
                                                      		 96664 - 97227 (+) activator of Hsp90 ATPase
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                                                        • ADM46376.1
                                                        • nat7
                                                        		 97324 - 98754 (-) metallopeptidase
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                                                          • ADM46377.1
                                                          • nat8
                                                          		 98931 - 99689 (+) gntr family transcriptional regulator
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                                                            • ADM46378.1
                                                            • nat9
                                                            		 99954 - 101543 (+) amino-acid permease transmembrane protein
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                                                              • ADM46379.1
                                                              • nat10
                                                              		 101969 - 102385 (+) hydrolase
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                                                                • ADM46380.1
                                                                • nat11
                                                                		 103250 - 105862 (+) magnesium or manganese-dependent protein phosphatase
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                                                                  Biosynthesis information

                                                                  No biosynthesis information available for this record.

                                                                  Annotation changelog

                                                                  Entry version: 4

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2022-10-07
                                                                  Update chemical activity to schema version 2.11
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 3

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2022-09-15
                                                                  Updated bioactivity data
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 2

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2019-10-16
                                                                  Migrated from v1.4
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  2019-10-16
                                                                  Updated compound(s) information (NPAtlas curation)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 1

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2015-06-12
                                                                  Submitted
                                                                  • (ID: HRPPCVKCIQDPTKAL4P4W6CV7)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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