Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000106.1:
Cluster 1Polyketide1106181

BGC0000106, naphthomycin biosynthetic gene cluster from Streptomyces sp. CS. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: naphthomycin
PubChem ID: 10101379
SMILES string: Copy to clipboard
Molecular formula: C40H46ClNO9
Average molecular mass: 720.256 Da
Molecular activity: Cytotoxic
Molecular target: DNA, RNA

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Ansamycin (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
Acetyl-CoA
Thioesterase type:
None
Release / cyclization type:
Macrolactamization

Gene cluster description

naphthomycin (BGC0000106). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank GQ452266, positions 1-106181. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?unknown
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Wu Yingying (Xiamen Univerwity, China)

Literature references

1. Wu Y et al. (2011) Cloning and functional analysis of the naphthomycin biosynthetic gene cluster in Streptomyces sp. CS. Mol Biosyst 7(8):2459-69. doi: 10.1039/c1mb05036b. Epub 2011 May 26.