LOCUS       BGC0000107              6819 bp    DNA     linear   PLN 27-FEB-2015
DEFINITION  TPA_asm: Aspergillus nidulans FGSC A4 chromosome II.
ACCESSION   BGC0000107
VERSION     BGC0000107
KEYWORDS    .
SOURCE      Aspergillus nidulans FGSC A4
  ORGANISM  Aspergillus nidulans FGSC A4
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus; Aspergillus subgen. Nidulantes.
COMMENT     Aspergillus nidulans FGSC A4 CADRE,
            updated by Eurofungbase with contributions from
            CADRE (http://www.cadre-genomes.org.uk),
            AspGD (http://www.aspergillusgenome.org) and
            Ensembl Genomes (http://www.ensemblgenomes.org).
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 16:11:18
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     mRNA            complement(join(1..1854,1899..2654,2705..6133,6183..6474,
                     6533..6819))
                     /gene="wA"
                     /locus_tag="ANIA_08209"
                     /note="transcript_id=CADANIAT00004256"
                     /old_locus_tag="AN8209.4"
     gene            complement(1..6819)
                     /gene="wA"
                     /locus_tag="ANIA_08209"
                     /old_locus_tag="AN8209.4"
     protocluster    1..6819
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[144:6819]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      145..6819
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     cand_cluster    1..6819
                     /SMILES="CC(=O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..6819
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000107"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..6819
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             complement(join(145..1854,1899..2654,2705..6133,6183..6474,
                     6533..6819))
                     /NRPS_PKS="Domain: SAT (7-244). E-value: 1.4e-86. Score:
                     281.8. Matches aSDomain: nrpspksdomains_ANIA_08209_SAT.1"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (378-807). E-value:
                     3.9e-149. Score: 488.9. Matches aSDomain:
                     nrpspksdomains_ANIA_08209_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (912-1212). E-value: 1.1e-86.
                     Score: 282.7. Matches aSDomain:
                     nrpspksdomains_ANIA_08209_PKS_AT.1"
                     /NRPS_PKS="Domain: PT (1289-1603). E-value: 1.3e-117.
                     Score: 384.5. Matches aSDomain:
                     nrpspksdomains_ANIA_08209_PT.1"
                     /NRPS_PKS="Domain: ACP (1654-1720). E-value: 9.2e-18.
                     Score: 56.2. Matches aSDomain:
                     nrpspksdomains_ANIA_08209_ACP.1"
                     /NRPS_PKS="Domain: PP-binding (1774-1838). E-value:
                     1.5e-13. Score: 43.0. Matches aSDomain:
                     nrpspksdomains_ANIA_08209_PP-binding.1"
                     /NRPS_PKS="Domain: Thioesterase (1896-2147). E-value:
                     1.7e-29. Score: 95.7. Matches aSDomain:
                     nrpspksdomains_ANIA_08209_Thioesterase.1"
                     /codon_start=1
                     /db_xref="EnsemblGenomes-Gn:CADANIAG00004256"
                     /db_xref="EnsemblGenomes-Tr:CADANIAT00004256"
                     /db_xref="GOA:Q03149"
                     /db_xref="InterPro:IPR001031"
                     /db_xref="InterPro:IPR001227"
                     /db_xref="InterPro:IPR006162"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="InterPro:IPR014030"
                     /db_xref="InterPro:IPR014031"
                     /db_xref="InterPro:IPR014043"
                     /db_xref="InterPro:IPR016035"
                     /db_xref="InterPro:IPR016036"
                     /db_xref="InterPro:IPR016038"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="InterPro:IPR018201"
                     /db_xref="InterPro:IPR020801"
                     /db_xref="InterPro:IPR029058"
                     /gene="wA"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 62.8; E-value:
                     4e-19)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ANIA_08209"
                     /note="transcript_id=CADANIAT00004256"
                     /old_locus_tag="AN8209.4"
                     /product="Conidial yellow pigment biosynthesis polyketide
                     synthase (PKS)(EC 2.3.1.-)
                     [Source:UniProtKB/Swiss-Prot;Acc:Q03149]"
                     /protein_id="CBF74114.1"
                     /sec_met_domain="PP-binding (E-value: 2.7e-15, bitscore:
                     43.0, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 2e-88, bitscore: 282.7,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="itr_KS (E-value: 9.7e-166, bitscore:
                     537.7, seeds: 96, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MEDPYRVYLFGDQTGDFEVGLRRLLQAKNHSLLSSFLQRSYHAVR
                     QEISHLPPSERSTFPRFTSIGDLLARHCESPGNPAIESVLTCIYQLGCFINYYGDLGHT
                     FPSHSQSQLVGLCTGLLSCAAVSCASNIGELLKPAVEVVVVALRLGLCVYRVRKLFGQD
                     QAAPLSWSALVSGLSESEGTSLIDKFTRRNVIPPSSRPYISAVCANTLTISGPPVVLNQ
                     FLDTFISGKNKAVMVPIHGPFHASHLYEKRDVEWILKSCNVETIRNHKPRIPVLSSNTG
                     ELIVVENMEGFLKIALEEILLRQMSWDKVTDSCISILKSVGDNKPKKLLPISSTATQSL
                     FNSLKKSNLVNIEVDGGISDFAAETQLVNQTGRAELSKIAIIGMSGRFPEADSPQDFWN
                     LLYKGLDVHRKVPEDRWDADAHVDLTGTATNTSKVPYGCWIREPGLFDPRFFNMSPREA
                     LQADPAQRLALLTAYEALEGAGFVPDSTPSTQRDRVGIFYGMTSDDYREVNSGQDIDTY
                     FIPGGNRAFTPGRINYYFKFSGPSVSVDTACSSSLAAIHLACNSIWRNDCDTAITGGVN
                     ILTNPDNHAGLDRGHFLSRTGNCNTFDDGADGYCRADGVGTVVLKRLEDALADNDPILG
                     VINGAYTNHSAEAVSITRPHVGAQAFIFKKLLNEANVDPKNISYIEMHGTGTQAGDAVE
                     MQSVLDVFAPDHRRGPGQSLHLGSAKSNIGHGESASGVTSLVKVLLMMKENMIPPHCGI
                     KTKINHNFPTDLAQRNVHIALQPTAWNRPSFGKRQIFLNNFSAAGGNTALLLEDGPVSD
                     PEGEDKRRTHVITLSARSQTALQNNIDALCQYISEQEKTFGVKDSNALPSLAYTTTARR
                     IHHPFRVTAIGSSFQEMRDSLIASSRKEFVAVPAKTPGIGFLFTGQGAQYAAMGKQLYE
                     DCSHFRSAIEHLDCISQGQDLPSILPLVDGSLPLSELSPVVVQLGTTCVQMALSSFWAS
                     LGITPSFVLGHSLGDFAAMNAAGVLSTSDTIYACGRRAQLLTERCQPGTHAMLAIKAPL
                     VEVKQLLNEKVHDMACINSPSETVISGPKSSIDELSRACSEKGLKSTILTVPYAFHSAQ
                     VEPILEDLEKALQGITFNKPSVPFVSALLGEVITEAGSNILNAEYLVRHCRETVNFLSA
                     FEAVRNAKLGGDQTLWLEVGPHTVCSGMVKATLGPQTTTMASLRRDEDTWKVLSNSLSS
                     LYLAGVDINWKQYHQDFSSSHRVLPLPTYKWDLKNYWIPYRNNFCLTKGSSMSAASASL
                     QPTFLTTSAQRVVESRDDGLTATVVVHNDIADPDLNRVIQGHKVNGAALCPSSLYADSA
                     QTLAEYLIEKYKPELKGSGLDVCNVTVPKPLIAKTGKEQFRISATANWVDKHVSVQVFS
                     VTAEGKKLIDHAHCEVKLFDCMAADLEWKRGSYLVKRSIELLENSAVKGDAHRLRRGMV
                     YKLFSALVDYDENYQSIREVILDSEHHEATALVKFQAPQANFHRNPYWIDSFGHLSGFI
                     MNASDGTDSKSQVFVNHGWDSMRCLKKFSADVTYRTYVRMQPWRDSIWAGNVYIFEGDD
                     IIAVFGGVKFQALSRKILDIALPPAGLSKAQTSPIQSSAPQKPIETAKPTSRPAPPVTM
                     KSFVKKSAGPSVVVRALNILASEVGLSESDMSDDLVFADYGVDSLLSLTVTGKYREELN
                     LDMDSSVFIEHPTVGDFKRFVTQLSPSVASDSSSTDRESEYSFNGDSCSGLSSPASPGT
                     VSPPNEKVIQIHENGTMKEIRAIIADEIGVSADEIKSDENLNELGMDSLLSLTVLGKIR
                     ESLDMDLPGEFFIENQTLDQIETALDLKPKAVPTAVPQSQPITLPQSQSTKQLSTRPTS
                     SSDNHPPATSILLQGNPRTASKTLFLFPDGSGSATSYATIPGVSPNVAVYGLNCPYMKA
                     PEKLTCSLDSLTTPYLAEIRRRQPTGPYNLGGWSAGGICAYDAARKLVLQQGEIVETLL
                     LLDTPFPIGLEKLPPRLYSFFNSIGLFGEGKAAPPAWLLPHFLAFIDSLDAYKAVPLPF
                     NEQEWKGKLPKTYLVWAKDGVCPKPGDPWPEPAEDGSKDPREMVWLLSNRTDLGPNGWD
                     TLVGKENIGGITVIHDANHFTMTKGEKAKELATFMKNALGVCERRLV"
     aSDomain        complement(178..930)
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ANIA_08209_Thioesterase.1"
                     /evalue="1.70E-29"
                     /label="ANIA_08209_Thioesterase.1"
                     /locus_tag="ANIA_08209"
                     /protein_end="2147"
                     /protein_start="1896"
                     /score="95.7"
                     /tool="antismash"
                     /translation="TLFLFPDGSGSATSYATIPGVSPNVAVYGLNCPYMKAPEKLTCSL
                     DSLTTPYLAEIRRRQPTGPYNLGGWSAGGICAYDAARKLVLQQGEIVETLLLLDTPFPI
                     GLEKLPPRLYSFFNSIGLFGEGKAAPPAWLLPHFLAFIDSLDAYKAVPLPFNEQEWKGK
                     LPKTYLVWAKDGVCPKPGDPWPEPAEDGSKDPREMVWLLSNRTDLGPNGWDTLVGKENI
                     GGITVIHDANHFTMTKGEKAKELATFMKN"
     aSModule        178..1296
                     /domains="nrpspksdomains_ANIA_08209_PP-binding.1"
                     /domains="nrpspksdomains_ANIA_08209_Thioesterase.1"
                     /final_module
                     /incomplete
                     /locus_tags="ANIA_08209"
                     /tool="antismash"
                     /type="unknown"
     CDS_motif       complement(679..753)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ANIA_08209_0008"
                     /evalue="7.50E-13"
                     /label="NRPS-te1"
                     /locus_tag="ANIA_08209"
                     /protein_end="1980"
                     /protein_start="1955"
                     /score="40.8"
                     /tool="antismash"
                     /translation="QPTGPYNLGGWSAGGICAYDAARKL"
     aSDomain        complement(1105..1296)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ANIA_08209_PP-binding.1"
                     /evalue="1.50E-13"
                     /label="ANIA_08209_PP-binding.1"
                     /locus_tag="ANIA_08209"
                     /protein_end="1838"
                     /protein_start="1774"
                     /score="43.0"
                     /tool="antismash"
                     /translation="EIRAIIADEIGVSADEIKSDENLNELGMDSLLSLTVLGKIRESLD
                     MDLPGEFFIENQTLDQIET"
     aSDomain        complement(1459..1656)
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ANIA_08209_ACP.1"
                     /evalue="9.20E-18"
                     /label="ANIA_08209_ACP.1"
                     /locus_tag="ANIA_08209"
                     /protein_end="1720"
                     /protein_start="1654"
                     /score="56.2"
                     /tool="antismash"
                     /translation="LNILASEVGLSESDMSDDLVFADYGVDSLLSLTVTGKYREELNLD
                     MDSSVFIEHPTVGDFKRFVTQ"
     aSModule        1459..5578
                     /complete
                     /domains="nrpspksdomains_ANIA_08209_PKS_KS.1"
                     /domains="nrpspksdomains_ANIA_08209_PKS_AT.1"
                     /domains="nrpspksdomains_ANIA_08209_PT.1"
                     /domains="nrpspksdomains_ANIA_08209_ACP.1"
                     /iterative
                     /locus_tags="ANIA_08209"
                     /monomer_pairings="mal -> mal"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(join(1810..1854,1899..2654,2705..2845))
                     /aSDomain="PT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ANIA_08209_PT.1"
                     /evalue="1.30E-117"
                     /label="ANIA_08209_PT.1"
                     /locus_tag="ANIA_08209"
                     /protein_end="1603"
                     /protein_start="1289"
                     /score="384.5"
                     /tool="antismash"
                     /translation="TTSAQRVVESRDDGLTATVVVHNDIADPDLNRVIQGHKVNGAALC
                     PSSLYADSAQTLAEYLIEKYKPELKGSGLDVCNVTVPKPLIAKTGKEQFRISATANWVD
                     KHVSVQVFSVTAEGKKLIDHAHCEVKLFDCMAADLEWKRGSYLVKRSIELLENSAVKGD
                     AHRLRRGMVYKLFSALVDYDENYQSIREVILDSEHHEATALVKFQAPQANFHRNPYWID
                     SFGHLSGFIMNASDGTDSKSQVFVNHGWDSMRCLKKFSADVTYRTYVRMQPWRDSIWAG
                     NVYIFEGDDIIAVFGGVKFQALSRKILDIALPP"
     CDS_motif       complement(join(2643..2654,2705..2719))
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ANIA_08209_0007"
                     /evalue="4.50E+01"
                     /label="PKSI-KS_m3"
                     /locus_tag="ANIA_08209"
                     /protein_end="1340"
                     /protein_start="1331"
                     /score="-2.0"
                     /tool="antismash"
                     /translation="ALCPSSLYA"
     aSDomain        complement(3077..3976)
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ANIA_08209_PKS_AT.1"
                     /evalue="1.10E-86"
                     /label="ANIA_08209_PKS_AT.1"
                     /locus_tag="ANIA_08209"
                     /protein_end="1212"
                     /protein_start="912"
                     /score="282.7"
                     /specificity="consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="LFTGQGAQYAAMGKQLYEDCSHFRSAIEHLDCISQGQDLPSILPL
                     VDGSLPLSELSPVVVQLGTTCVQMALSSFWASLGITPSFVLGHSLGDFAAMNAAGVLST
                     SDTIYACGRRAQLLTERCQPGTHAMLAIKAPLVEVKQLLNEKVHDMACINSPSETVISG
                     PKSSIDELSRACSEKGLKSTILTVPYAFHSAQVEPILEDLEKALQGITFNKPSVPFVSA
                     LLGEVITEAGSNILNAEYLVRHCRETVNFLSAFEAVRNAKLGGDQTLWLEVGPHTVCSG
                     MVKATLGPQTTTMASLRRD"
     CDS_motif       complement(3626..3742)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ANIA_08209_0006"
                     /evalue="4.50E-11"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="ANIA_08209"
                     /protein_end="1029"
                     /protein_start="990"
                     /score="34.7"
                     /tool="antismash"
                     /translation="GITPSFVLGHSLGDFAAMNAAGVLSTSDTIYACGRRAQL"
     CDS_motif       complement(3926..3973)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ANIA_08209_0005"
                     /evalue="1.40E-05"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="ANIA_08209"
                     /protein_end="929"
                     /protein_start="913"
                     /score="17.6"
                     /tool="antismash"
                     /translation="FTGQGAQYAAMGKQLY"
     aSDomain        complement(4292..5578)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ANIA_08209_PKS_KS.1"
                     /domain_subtype="Iterative-KS"
                     /evalue="3.90E-149"
                     /label="ANIA_08209_PKS_KS.1"
                     /locus_tag="ANIA_08209"
                     /protein_end="807"
                     /protein_start="378"
                     /score="488.9"
                     /tool="antismash"
                     /translation="IAIIGMSGRFPEADSPQDFWNLLYKGLDVHRKVPEDRWDADAHVD
                     LTGTATNTSKVPYGCWIREPGLFDPRFFNMSPREALQADPAQRLALLTAYEALEGAGFV
                     PDSTPSTQRDRVGIFYGMTSDDYREVNSGQDIDTYFIPGGNRAFTPGRINYYFKFSGPS
                     VSVDTACSSSLAAIHLACNSIWRNDCDTAITGGVNILTNPDNHAGLDRGHFLSRTGNCN
                     TFDDGADGYCRADGVGTVVLKRLEDALADNDPILGVINGAYTNHSAEAVSITRPHVGAQ
                     AFIFKKLLNEANVDPKNISYIEMHGTGTQAGDAVEMQSVLDVFAPDHRRGPGQSLHLGS
                     AKSNIGHGESASGVTSLVKVLLMMKENMIPPHCGIKTKINHNFPTDLAQRNVHIALQPT
                     AWNRPSFGKRQIFLNNFSAAGGNTALLLED"
     CDS_motif       complement(4520..4564)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ANIA_08209_0004"
                     /evalue="1.10E-02"
                     /label="PKSI-KS_m6"
                     /locus_tag="ANIA_08209"
                     /protein_end="731"
                     /protein_start="716"
                     /score="8.8"
                     /tool="antismash"
                     /translation="GSAKSNIGHGESASG"
     CDS_motif       complement(4631..4678)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ANIA_08209_0003"
                     /evalue="6.30E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="ANIA_08209"
                     /protein_end="694"
                     /protein_start="678"
                     /score="12.1"
                     /tool="antismash"
                     /translation="YIEMHGTGTQAGDAVE"
     CDS_motif       complement(4871..4909)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ANIA_08209_0002"
                     /evalue="3.70E-03"
                     /label="PKSI-KS_m4"
                     /locus_tag="ANIA_08209"
                     /protein_end="614"
                     /protein_start="601"
                     /score="10.6"
                     /tool="antismash"
                     /translation="FDDGADGYCRADG"
     CDS_motif       complement(5051..5098)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ANIA_08209_0001"
                     /evalue="4.20E-06"
                     /label="PKSI-KS_m3"
                     /locus_tag="ANIA_08209"
                     /protein_end="554"
                     /protein_start="538"
                     /score="18.8"
                     /tool="antismash"
                     /translation="GPSVSVDTACSSSLAA"
     aSDomain        complement(join(5981..6133,6183..6474,6533..6798))
                     /aSDomain="SAT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ANIA_08209_SAT.1"
                     /evalue="1.40E-86"
                     /label="ANIA_08209_SAT.1"
                     /locus_tag="ANIA_08209"
                     /protein_end="244"
                     /protein_start="7"
                     /score="281.8"
                     /tool="antismash"
                     /translation="YLFGDQTGDFEVGLRRLLQAKNHSLLSSFLQRSYHAVRQEISHLP
                     PSERSTFPRFTSIGDLLARHCESPGNPAIESVLTCIYQLGCFINYYGDLGHTFPSHSQS
                     QLVGLCTGLLSCAAVSCASNIGELLKPAVEVVVVALRLGLCVYRVRKLFGQDQAAPLSW
                     SALVSGLSESEGTSLIDKFTRRNVIPPSSRPYISAVCANTLTISGPPVVLNQFLDTFIS
                     GKNKAVMVPIHGPFH"
ORIGIN
        1 tattagaacc agaggattat tattgtttac cctttatgtt tagagtacaa gatgaaacgg
       61 gaaagtaaaa ccttatgagc aacaatagaa tagcattaat ggatcaaaac ctaagccaaa
      121 accaaagcaa acaaattgac attatcagac caaccggcgc tcacaaaccc ccaacgcatt
      181 cttcatgaaa gtagcaagct cctttgcctt ttcgcccttt gtcatagtaa agtgattcgc
      241 gtcatgaatc actgtaatac cgccaatatt ttccttgccc acaagcgtat cccatccatt
      301 cggacccaga tccgtccggt tagaaagtaa ccaaaccatc tcgcgtggat ccttgctccc
      361 gtcctccgca ggctcaggcc acggatcacc aggcttaggg cagaccccat ccttagccca
      421 aacaaggtac gtttttggca gctttccctt ccattcctgt tcgttgaagg gaagaggcac
      481 ggccttgtac gcgtcgaggg agtcaatgaa cgccaaaaaa tggggaagta gccaagccgg
      541 cggcgcggcc ttgccttcgc caaagaggcc gatcgagttg aagaagctgt acaggcgggg
      601 cgggagtttc tcaaggccaa tggggaaggg ggtgtcgaga agaagaaggg tctcgactat
      661 ttcgccctgc tgcagtacga gcttgcgtgc cgcgtcgtat gcgcagatcc cgcctgcgga
      721 ccagccgcca aggttgtacg ggccggttgg ttggcggcgg cgaatctcgg cgagatacgg
      781 cgttgtcagc gaatcgaggc tgcaggtgag cttttcgggg gctttcatgt aggggcagtt
      841 gaggccataa acggcaacgt ttggggagac tccgggtatt gtggcgtagg aggttgcgga
      901 gccagaaccg tcggggaaga gaaagagggt ctttgacgct gtgcgcgggt ttccttggag
      961 gagaatggag gttgccgggg gatggttgtc gctgctgctg gtaggtcgcg tggaaagctg
     1021 tttcgttgat tgtgattgtg gtagggttat gggctgcgat tgtgggacag cggtcgggac
     1081 agctttgggc ttcaggtcca gcgcagtctc aatctggtcc agggtctggt tctcgatgaa
     1141 gaactctccc ggcaggtcca tgtccagtga ctcgcggatt ttgcctagga ctgtaagtga
     1201 gagaagcgag tccattccca attcatttag gttttcatcg ctcttgattt cgtctgccga
     1261 gacaccaatt tcgtcggcta taatggcgcg aatctctttc atagtgccgt tctcatgaat
     1321 ttggataacc ttctcatttg gtggcgatac ggtgccaggc gatgctggac ttgatagccc
     1381 ggaacagctg tcaccattga atgaatactc agactcacgg tcagtcgacg acgaatcact
     1441 agctactgac ggactgagtt gagtcacaaa gcgcttgaag tcgccgaccg ttggatgctc
     1501 aatgaaaact gaagaatcca tgtctaggtt cagctcctct cgatacttgc cagttactgt
     1561 caaggaaaga agggaatcga caccatagtc tgcaaacacc agatcgtcag acatgtcgga
     1621 ttctgagagt cctacttctg atgctaggat attgagcgct cgcactacca cacttgggcc
     1681 agcggacttc ttgacgaatg atttcattgt caccggaggg gctggccgcg aggtgggttt
     1741 tgcagtttca atcggcttct ggggagctga ggactggatt ggcgaggtct gcgccttcga
     1801 cagtcctgct ggcggaagag caatgtcgag gatcttgcgc gatagggctt ggaactgtta
     1861 aatgttagcg atattccttt cggccaaaat ttccttacct taacaccgcc aaatactgcg
     1921 ataatatcat caccctcgaa tatgtagaca tttcctgccc agatcgagtc gcgccaaggt
     1981 tgcatcctga cataggtacg gtaggtgaca tctgctgaga acttcttcaa gcaccgcatg
     2041 gagtcccatc catgattaac gaagacttga cttttggagt ctgttccatc gctagcattc
     2101 attatgaagc cagacaaatg cccaaaactg tcgatccagt atgggttacg gtgaaagttg
     2161 gcttgcggtg cctggaactt gaccagagcc gtcgcctcgt gatgctcact atcaaggata
     2221 acttcacgga tagattggta gttttcatcg tagtcgacca aagcgctgaa gagtttatag
     2281 accattcctc tccgcaggcg atgggcatct cctttcacag cactattttc gagaagctca
     2341 atgcttcgct tgaccagata cgaacctctc ttccattcaa gatcagcggc catgcagtcg
     2401 aaaagtttga cttcgcagtg cgcgtggtcg atgagctttt tgccctccgc ggtaacggag
     2461 aagacttgca cagatacgtg tttgtccacc caattggcag tcgccgaaat tctgaattgc
     2521 tcctttccag tttttgcaat aagaggtttg ggaaccgtta cattgcatac gtccaaacct
     2581 gagcctttga gctctggctt gtacttttca atgaggtatt ctgcaagggt ttgagcacta
     2641 tctgcataaa gagacttaaa gtctgtcagg cctgattcat agcaaatccg aggggcttac
     2701 ttactgaagg acagagtgca gctccattga ccttgtggcc ctggataact cgattcaagt
     2761 ccgggtcggc tatgtcattg tgcactacta cggttgccgt taatccatcg tcacggctct
     2821 caacgactct ctgggcagac gttgtcagga aagtcggctg tagagacgcg ctcgcggcag
     2881 acatagaaga gcccttggtg agacagaagt tgttcctgta gggaatccag taattcttca
     2941 aatcccactt gtaggttggt agcggaagta ctctgtggct ggaggagaag tcctgatgat
     3001 attgcttcca gttgatgtca acgcccgcca aataaagact tgacaggcta ttggaaagga
     3061 ctttccatgt gtcctcgtcg cggcggagag acgccatggt ggttgtttgt ggtccaagcg
     3121 tggccttgac cattccggaa caaaccgtat gcgggccgac ctcgagccag agagtctgat
     3181 caccaccgag ctttgcattt ctcactgctt caaacgcact cagaaaattg acagtttccc
     3241 ggcagtgtct taccaggtat tcagcgttta ggatgttaga gcccgcttcc gtaattactt
     3301 ccccgagcaa cgctgaaaca aacggcacgg acggtttgtt gaaggtgatt ccctgcagag
     3361 ccttctcaag gtcttccaaa ataggttcaa cctgggcaga atggaaagcg tagggcactg
     3421 tcagaatagt tgatttcagt cctttctctg agcaggcccg ggagagctca tcaatgctag
     3481 acttaggacc gctaatgacg gtttctgaag gcgaattaat acatgccata tcatgaacct
     3541 tctcgttcaa gagctgtttg acctcgacta gtggggcttt aatggccagc atggcatgtg
     3601 ttcccggttg gcatcgctct gtgaggagct gggcacgacg accacaagca tagatggtat
     3661 cactggtcga tagaactccg gcagcgttca tagcagcaaa gtccccaaga ctatgcccaa
     3721 gaacgaagga tggcgttatt cctaatgatg cccaaaaact ggacaaagcc atctgcacgc
     3781 atgtagtccc cagttgtaca acaacaggac tcagttcgct caaaggcaag ctgccatcaa
     3841 caagaggaag aattgatgga agatcctggc cttggctgat gcaatccaag tgctctatgg
     3901 cggatcgaaa gtgtgaacag tcctcataca attgtttgcc catggctgca tattgggcac
     3961 cctggccagt aaagaggaac ccgataccag gggtctttgc aggcaccgcg acaaattcct
     4021 ttcgggagct cgcaattaga gaatcgcgca tttcctgaaa gctagaccca atagcagtga
     4081 ctcggaaagg gtggtgaatg cggcgtgcgg tcgtagtata cgccaaactc ggcagggcat
     4141 tgctgtcctt gacaccgaat gtcttttctt gctcactgat gtactgacac agtgcgtcga
     4201 tattgttttg aagagcggtt tgagatcgag cagaaagcgt gataacgtgc gttcgccgtt
     4261 tgtcctcccc ttccggatca gaaacgggcc catcttccag caaaagcgcg gtatttccac
     4321 cggctgcgga aaaattgttc aagaatatct ggcgtttgcc aaatgaaggt cgattccaag
     4381 ctgtgggctg cagtgcgata tggacattcc tttgcgccag gtcagttggg aaattatgat
     4441 tgatcttcgt cttgatgcca caatgcggag gtatcatgtt ttccttcatc atcagcagca
     4501 ccttgactag agaagtcaca cctgacgctg attcaccgtg acctatattt gattttgcag
     4561 agccaagatg tagggactgt cctggcccgc gtctgtggtc tggtgcaaag acatccaaga
     4621 ccgattgcat ttccaccgca tccccagcct gggtaccagt tccatgcatc tcgatgtagc
     4681 ttatgttctt ggggtcaacg tttgcttcat ttagcaactt cttaaagata aatgcttgtg
     4741 cgccgacatg gggacgggtg attgagactg cctctgctga gtggttcgta tatgcgccgt
     4801 taatgacacc aagaattgga tcattatctg ccaaagcatc ttcaagccgc ttcagaacga
     4861 cagtgccaac accatctgct ctgcaatatc catcggctcc gtcatcgaac gtgttgcagt
     4921 ttccggttct ggaaaggaaa tggccacggt ccagaccagc atggttgtct gggttggtca
     4981 ggatgtttac accaccagta atagccgtgt cacagtcatt tctccaaatg gaattgcagg
     5041 ccaagtggat agccgcgagg ctagaagagc aagctgtatc aacactcaca ctgggcccgc
     5101 tgaatttgaa gtaatagttg atccggccgg gagtaaaagc acggttgccc cctggaataa
     5161 agtaggtatc gatatcctga ccactgttga cctctctgta gtcatcactg gtcatcccgt
     5221 agaagatacc aactctatcc ctttgcgtcg atggcgtact atctggaaca aatccagccc
     5281 cttccaatgc ctcatacgct gtgagcaatg caagccgttg agcaggatct gcttgaagtg
     5341 cttcacgggg tgacatgttg aagaagcgag gatcgaataa gccaggctcc cgaatccagc
     5401 atccgtaagg gaccttgctt gtattcgttg ctgtgccggt gaggtcaacg tgcgcatcag
     5461 catcccacct gtcttcaggg acttttcgat gcacgtcaag gcctttgtat aggaggttcc
     5521 aaaagtcctg tggactatca gcttcaggaa accgacccga catcccaata atggctatct
     5581 ttgaaagttc agccctgcct gtctggttga caagttgagt ttctgccgcg aagtcgctaa
     5641 ttcctccatc cacttcgata ttcactaggt ttgatttctt gagtgagttg aataaacttt
     5701 gcgtagccgt agatgagatt ggaagcaact tcttgggttt gttatcgccg actgacttca
     5761 aaatcgatat gcatgaatct gtcaccttat cccaagacat ttggcgaagc agaatctctt
     5821 ctaaagcaat tttgagaaaa ccttccatat tttcaacaac gatgagctcc ccagtattgc
     5881 ttgacagaac cggaatacgg ggcttatggt tgcggattgt ttcaacgttg caggacttaa
     5941 gaatccactc cacgtcccgc ttctcatata gatgagaggc atgaaacggg ccgtggattg
     6001 gcaccataac agctttattc tttcctgaaa tgaaagtatc cagaaactgg ttgagaacaa
     6061 ccgggggacc actaatggtc aacgtgtttg cgcatactgc gctaatgtac ggccgagacg
     6121 aaggagggat aacctagctg gtcaatatcg aagtgttacg aaatccttat agggagactc
     6181 acatttcggc gggtaaattt gtctatcaag ctcgttcctt cggattcact caaaccggac
     6241 acaagagctg accagctgag tggcgctgct tgatcttgac caaacagttt tcgcactcgg
     6301 taaacacaga gtcccaaccg gagggctaca acaaccactt caacagctgg tttgagtaat
     6361 tcgccaatgt tacttgcaca gctgaccgcg gcacagctga gcaaacctgt acacaaccca
     6421 acgagttggc tctgggagtg cgaagggaat gtatgaccaa ggtcaccata gtaactgata
     6481 ccgtcagcaa cagtttctat tcagcagact ataggctata aatgtaacat acttgataaa
     6541 acatcccaat tgatatatgc atgtcaacac gctctcgatc gcagggtttc ccggagattc
     6601 acagtgccgt gctagtagat caccaatgct tgtgaatcga ggaaatgtgc tgcgctcaga
     6661 gggcggaaga tgagagatct cttgccgcac tgcatggtag cttctctgga gaaagctcga
     6721 aaggagagag tgattctttg cctgtagcag acgacggaga ccgacctcaa aatcacctgt
     6781 ctgatctccg aagagataga cacggtatgg gtcctccat
//
