BGC0000109: LL-F28249α biosynthetic gene cluster from Streptomyces cyaneogriseus subsp. noncyanogenus
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 80,358 nt. (total: 80,358 nt).
This entry is originally from NCBI GenBank AB363939.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000109
Short description LL-F28249α biosynthetic gene cluster from Streptomyces cyaneogriseus subsp. noncyanogenus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
AB363939.1
via
Compounds
  • LL-F28249α
Species Streptomyces cyaneogriseus subsp. noncyanogenus [taxonomy]
References
  • [1]
Chemical products information
LL-F28249α Evidence:
Copy SMILES
C36H52O8
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAF85834.1
  • nemR
 1013 - 3781 (-) transcriptional regulatory protein
    copy AA seq
    copy Nt seq
    • BAF85835.1
    • nemG
    		 4107 - 4886 (+) thioesterase type II
      copy AA seq
      copy Nt seq
      • BAF85836.1
      • nemF
      		 4975 - 5778 (-) C5-ketoreductase
        copy AA seq
        copy Nt seq
        • BAF85837.1
        • nemA1-1
        		 6166 - 13191 (+) modular polyketide synthase
          copy AA seq
          copy Nt seq
          • BAF85838.1
          • nemA1-2
          		 13181 - 24352 (+) modular polyketide synthase
            copy AA seq
            copy Nt seq
            • BAF85839.1
            • nemA2
            		 24431 - 42562 (+) modular polyketide synthase
              copy AA seq
              copy Nt seq
              • BAF85840.1
              • nemC
              		 42791 - 43702 (+) post-polyketide modification protein
                copy AA seq
                copy Nt seq
                • BAF85841.1
                • nemD
                		 43763 - 44617 (-) C5-O-methyltransferase
                  copy AA seq
                  copy Nt seq
                  • BAF85842.1
                  • nemE
                  		 44614 - 46020 (-) cytochrome P450 hydroxylase
                    copy AA seq
                    copy Nt seq
                    • BAF85843.1
                    • nemA3
                    		 46123 - 63147 (-) modular polyketide synthase
                      copy AA seq
                      copy Nt seq
                      • BAF85844.1
                      • nemA4
                      		 63243 - 78743 (-) modular polyketide synthase
                        copy AA seq
                        copy Nt seq
                        • BAF85845.1
                        		 78888 - 79652 (+) putative oxidoreductase
                          copy AA seq
                          copy Nt seq
                          Biosynthesis information
                          Annotation changelog

                          Entry version: 4

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-10-07
                          Update chemical activity to schema version 2.11
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 3

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-09-15
                          Updated bioactivity data
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 2

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2019-10-16
                          Migrated from v1.4
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2019-10-16
                          Updated reference publication(s) (MIBiG Annotathon)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2019-10-16
                          Updated compound(s) information (NPAtlas curation)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 1

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2015-06-12
                          Submitted
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          Detailed domain annotation
                          Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                          A domain glossary is available here, and an explanation of the visualisation is available here.
                          Selected features only
                          Show module domains
                          Similar known gene clusters from MIBiG 4.0
                          Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                          Click on reference genes to show details of similarities to genes within the current region.
                          Click on an accession to open that entry in the MiBIG database.