BGC0000110: spectinabilin biosynthetic gene cluster from Streptomyces orinoci
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 38,365 nt. (total: 38,365 nt).
This entry is originally from NCBI GenBank AM778535.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000110
Short description spectinabilin biosynthetic gene cluster from Streptomyces orinoci
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "The AT domain within module 6 is inactive and thus module 6 uses the AT domain from module 5."
Biosynthetic class(es)
  • PKS (Type I)
Loci
AM778535.1
via Heterologous expression
Compounds
  • spectinabilin
  • orinocin
  • SNF4435C
  • SNF4435D
Species Streptomyces orinoci [taxonomy]
References
Chemical products information
spectinabilin Evidence:
Copy SMILES
C28H31N1O6
Chemical database entries
NPAtlas
orinocin Evidence:
Copy SMILES
C19H19N1O6
Chemical database entries
NPAtlas
SNF4435C Evidence:
Copy SMILES
C28H31N1O6
Chemical database entries
NPAtlas
ChemSpider
SNF4435D Evidence:
Copy SMILES
C28H31N1O6
Chemical database entries
NPAtlas
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAO85889.1
  • norD
 1 - 390 (+) regulator protein NorD
    copy AA seq
    copy Nt seq
    • CAO85890.1
    • norE
    		 387 - 2237 (-) aryl-coA ligase
      copy AA seq
      copy Nt seq
      • CAO85891.1
      • norF
      		 2170 - 3186 (+) N-oxygenase
        copy AA seq
        copy Nt seq
        • CAO85892.1
        • norJ
        		 3223 - 4287 (+) NorJ protein
          copy AA seq
          copy Nt seq
          • CAO85893.1
          • norA
          		 4343 - 10036 (+) modular polyketide synthase NorA
            copy AA seq
            copy Nt seq
            • CAO85894.1
            • norG
            		 10047 - 12158 (+) PABA synthase
              copy AA seq
              copy Nt seq
              • CAO85895.1
              • norH
              		 12208 - 13428 (+) cytochrome P-450 monooxygenase
                copy AA seq
                copy Nt seq
                • CAO85896.1
                • norA_
                		 13478 - 24355 (+) protein modular polyketide synthase NorA'
                  copy AA seq
                  copy Nt seq
                  • CAO85897.1
                  • norB
                  		 24342 - 30866 (+) modular polyketide synthase NorB
                    copy AA seq
                    copy Nt seq
                    • CAO85898.1
                    • norC
                    		 30873 - 37673 (+) modular polyketide synthase NorC
                      copy AA seq
                      copy Nt seq
                      • CAO85899.1
                      • norI
                      		 37673 - 38365 (+) methyltransferase NorI
                        copy AA seq
                        copy Nt seq
                        Biosynthesis information

                        Biosynthetic modules

                        Name
                        1
                        Type
                        pks-modular
                        Genes
                        norA
                        Substrates
                        Integrated Monomers
                        Domains
                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                        Name
                        2
                        Type
                        pks-modular
                        Genes
                        norA_
                        Substrates
                        Integrated Monomers
                        Domains
                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                        Name
                        3
                        Type
                        pks-modular
                        Genes
                        norA_
                        Substrates
                        Integrated Monomers
                        Domains
                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                        Name
                        4
                        Type
                        pks-modular
                        Genes
                        norB
                        Substrates
                        Integrated Monomers
                        Domains
                        acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
                        Name
                        5
                        Type
                        pks-modular
                        Genes
                        norC
                        Substrates
                        Integrated Monomers
                        Domains
                        acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                        Name
                        6
                        Type
                        pks-trans-at
                        Genes
                        norC
                        Substrates
                        Integrated Monomers
                        Domains
                        ketosynthase, carrier (ACP)
                        Annotation changelog

                        Entry version: 4

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-10-07
                        Update chemical activity to schema version 2.11
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 3

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-09-15
                        Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2022-09-15
                        Updated bioactivity data
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 2

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2019-10-16
                        Migrated from v1.4
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2019-10-16
                        Updated compound(s) information (NPAtlas curation)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 1

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2015-06-12
                        Submitted
                        • (ID: F65XGYSSLMUEJC2Q4T3BLCPS)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        Detailed domain annotation
                        Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                        A domain glossary is available here, and an explanation of the visualisation is available here.
                        Selected features only
                        Show module domains
                        Similar known gene clusters from MIBiG 4.0
                        Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                        Click on reference genes to show details of similarities to genes within the current region.
                        Click on an accession to open that entry in the MiBIG database.