BGC0000111 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000111 (Streptomyces carzinostaticus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	33,079	High	neocarzilin A/neocarzilin B	PKS

BGC0000111 - Region 1 - T1PKS

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Location: 1 - 33,079 nt. (total: 33,079 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

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TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 33,080
Label		BGC0000111

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

BAD38873.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

BAD38877.1: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

Transferases: halogenase

BAD38872.1: conventional flavin-dependent halogenase

halogenases: conventional flavin-dependent halogenase
smcogs: SMCOG1119: halogenase

Hydrolases: esterase

BAD38876.1: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: ligase synthase

BAD38874.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

BAD38875.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

BAD38878.1: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

BAD38880.1: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000111.5	1.00	PKS	neocarzilin A, neocarzilin B	Streptomyces carzinostaticus
BGC0001535.3	0.82	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001275.3	0.77	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.77	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.67	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0000041.3	0.67	PKS	oronofacic acid	Pseudomonas syringae
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001257.3	0.65	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000111.5	1.00	PKS	neocarzilin A, neocarzilin B	Streptomyces carzinostaticus
BGC0001535.3	0.82	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001275.3	0.77	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.77	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.67	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0000041.3	0.67	PKS	oronofacic acid	Pseudomonas syringae
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001257.3	0.65	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 33079:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (ccmal)
Non-colinear ordering:: BAD38873.1 + BAD38874.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

BAD38873.1: pk

PKS_AT (554..858): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; Methylmalonyl-CoA: 83.3%; Methoxymalonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 147.1
Ethylmalonyl-CoA: 124.0
Methoxymalonyl-CoA: 110.5
Malonyl-CoA: 97.7
Propionyl-CoA: 73.7
2-Methylbutyryl-CoA: 65.4
Isobutyryl-CoA: 63.5
trans-1,2-CPDA: 60.9
Benzoyl-CoA: 58.3
CHC-CoA: 54.6
Acetyl-CoA: 40.3
3-Methylbutyryl-CoA: 21.4
inactive: 16.9
fatty_acid: 14.5

BAD38874.1: mal

PKS_AT (1810..2100): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 188.0
inactive: 117.4
Methoxymalonyl-CoA: 69.4
Methylmalonyl-CoA: 67.6
Propionyl-CoA: 53.9
Isobutyryl-CoA: 47.8
Ethylmalonyl-CoA: 31.6
Benzoyl-CoA: 31.4
2-Methylbutyryl-CoA: 27.5
Acetyl-CoA: 19.2
CHC-CoA: 16.5
trans-1,2-CPDA: 13.9
fatty_acid: 11.7
3-Methylbutyryl-CoA: 8.8

Link to PARAS substrate predictor