BGC0000111 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000111 (Streptomyces carzinostaticus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	33,079	neocarzilin A/neocarzilin B	PKS	100%

BGC0000111 - Region 1 - T1PKS

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Location: 1 - 33,079 nt. (total: 33,079 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 33,080
Label		BGC0000111

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000111	1.00	Polyketide	neocarzilin A, neocarzilin B	Streptomyces carzinostaticus
BGC0001535	0.44	Other	branched-chain fatty acids	Streptomyces filamentosus
BGC0001275	0.35	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273	0.34	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001244	0.32	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0000041	0.31	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000996	0.30	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0001219	0.29	Polyketide	shanorellin	Chaetomium globosum CBS 148.51
BGC0002229	0.28	Polyketide	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872
BGC0002615	0.27	Terpene	4-oxomacrophorin A, macrophorin A, 5'-epimacrophorin B	Penicillium terrestre

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000111	1.00	Polyketide	neocarzilin A, neocarzilin B	Streptomyces carzinostaticus
BGC0001535	0.75	Other	branched-chain fatty acids	Streptomyces filamentosus
BGC0001275	0.68	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273	0.67	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001244	0.66	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0000041	0.64	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000996	0.64	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0001219	0.62	Polyketide	shanorellin	Chaetomium globosum CBS 148.51
BGC0002229	0.61	Polyketide	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872
BGC0002615	0.60	Terpene	4-oxomacrophorin A, macrophorin A, 5'-epimacrophorin B	Penicillium terrestre

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 33079:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (ccmal)
Non-colinear ordering:: BAD38873.1 + BAD38874.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

BAD38873.1

PKS_AT (554..858): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; Methylmalonyl-CoA: 83.3%; Methoxymalonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 147.1
Ethylmalonyl-CoA: 124.0
Methoxymalonyl-CoA: 110.5
Malonyl-CoA: 97.7
Propionyl-CoA: 73.7
2-Methylbutyryl-CoA: 65.4
Isobutyryl-CoA: 63.5
trans-1,2-CPDA: 60.9
Benzoyl-CoA: 58.3
CHC-CoA: 54.6
Acetyl-CoA: 40.3
3-Methylbutyryl-CoA: 21.4
inactive: 16.9
fatty_acid: 14.5

BAD38874.1

PKS_AT (1810..2100): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 188.0
inactive: 117.4
Methoxymalonyl-CoA: 69.4
Methylmalonyl-CoA: 67.6
Propionyl-CoA: 53.9
Isobutyryl-CoA: 47.8
Ethylmalonyl-CoA: 31.6
Benzoyl-CoA: 31.4
2-Methylbutyryl-CoA: 27.5
Acetyl-CoA: 19.2
CHC-CoA: 16.5
trans-1,2-CPDA: 13.9
fatty_acid: 11.7
3-Methylbutyryl-CoA: 8.8