BGC0000113 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000113 (Streptomyces caelestis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	41,097	High	niddamycin	PKS

BGC0000113 - Region 1 - T1PKS

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Location: 1 - 41,097 nt. (total: 41,097 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 41,098
Label		BGC0000113

Tailoring functions

Transferases: acylase methyltransferase

AAC46029.1: methyltransferase

smcogs: SMCOG1248: methyltransferase

nidA3: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Ligases: synthase

nidA1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

nidA2: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

nidA4: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

nidA5: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000113.5	1.00	PKS	niddamycin	Streptomyces caelestis
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0000018.5	0.70	PKS	angolamycin	Streptomyces eurythermus
BGC0000041.3	0.69	PKS	oronofacic acid	Pseudomonas syringae
BGC0001273.3	0.67	PKS	asperlactone	Aspergillus ochraceus
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000113.5	1.00	PKS	niddamycin	Streptomyces caelestis
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0000018.5	0.70	PKS	angolamycin	Streptomyces eurythermus
BGC0000041.3	0.69	PKS	oronofacic acid	Pseudomonas syringae
BGC0001273.3	0.67	PKS	asperlactone	Aspergillus ochraceus
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 41097:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ohmal - ccmal) + (ccmal) + (Me-ohmal - redemal) + (ohmxmal) + (ohmal)
Non-colinear ordering:: nidA1 + nidA2 + nidA3 + nidA4 + nidA5

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

nidA1: mal - mal - mal

PKS_AT (537..828): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 192.2
inactive: 81.9
Methoxymalonyl-CoA: 74.9
Methylmalonyl-CoA: 65.1
Propionyl-CoA: 47.6
Isobutyryl-CoA: 24.1
Ethylmalonyl-CoA: 20.6
2-Methylbutyryl-CoA: 18.8
CHC-CoA: 16.0
Acetyl-CoA: 15.7
fatty_acid: 15.4
trans-1,2-CPDA: 12.4
Benzoyl-CoA: 12.3
3-Methylbutyryl-CoA: 8.8

PKS_AT (1530..1821): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 196.4
inactive: 81.2
Methoxymalonyl-CoA: 72.9
Methylmalonyl-CoA: 64.1
Propionyl-CoA: 42.8
Isobutyryl-CoA: 25.7
Ethylmalonyl-CoA: 20.4
Acetyl-CoA: 17.9
CHC-CoA: 16.2
fatty_acid: 15.2
2-Methylbutyryl-CoA: 13.4
Benzoyl-CoA: 11.9
trans-1,2-CPDA: 8.6
3-Methylbutyryl-CoA: 0.0

PKS_AT (2990..3281): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 202.0
inactive: 87.2
Methoxymalonyl-CoA: 79.4
Methylmalonyl-CoA: 68.1
Propionyl-CoA: 47.9
Isobutyryl-CoA: 29.7
Ethylmalonyl-CoA: 25.3
2-Methylbutyryl-CoA: 20.4
Acetyl-CoA: 18.1
fatty_acid: 16.3
CHC-CoA: 15.3
trans-1,2-CPDA: 12.6
Benzoyl-CoA: 11.9
3-Methylbutyryl-CoA: 0.0

nidA2: mal

PKS_AT (563..854): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.1
inactive: 84.8
Methoxymalonyl-CoA: 76.3
Methylmalonyl-CoA: 65.9
Propionyl-CoA: 47.2
Isobutyryl-CoA: 27.7
Ethylmalonyl-CoA: 23.8
2-Methylbutyryl-CoA: 18.7
Acetyl-CoA: 18.1
fatty_acid: 17.8
CHC-CoA: 15.3
Benzoyl-CoA: 11.9
trans-1,2-CPDA: 11.5
3-Methylbutyryl-CoA: 0.0

nidA3: mmal - emal

PKS_AT (569..872): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 214.3
Ethylmalonyl-CoA: 205.4
Methoxymalonyl-CoA: 174.3
2-Methylbutyryl-CoA: 141.0
trans-1,2-CPDA: 119.5
Propionyl-CoA: 118.4
Malonyl-CoA: 113.3
CHC-CoA: 91.8
Isobutyryl-CoA: 87.8
Benzoyl-CoA: 75.1
Acetyl-CoA: 47.8
inactive: 41.5
fatty_acid: 33.0
3-Methylbutyryl-CoA: 32.2

PKS_AT (2009..2306): emal

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Methylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 248.7
Methylmalonyl-CoA: 209.7
Methoxymalonyl-CoA: 188.1
trans-1,2-CPDA: 168.8
2-Methylbutyryl-CoA: 148.2
Propionyl-CoA: 122.6
CHC-CoA: 98.9
Malonyl-CoA: 92.1
Isobutyryl-CoA: 75.0
Benzoyl-CoA: 65.5
Acetyl-CoA: 54.9
fatty_acid: 46.5
3-Methylbutyryl-CoA: 32.6
inactive: 27.8

nidA4: mxmal

PKS_AT (574..872): mxmal

ATSignature: Methylmalonyl-CoA, Methoxymalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 100.0%; Ethylmalonyl-CoA: 91.7%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 198.1
Ethylmalonyl-CoA: 184.0
Methylmalonyl-CoA: 180.3
trans-1,2-CPDA: 110.3
2-Methylbutyryl-CoA: 99.7
Malonyl-CoA: 92.5
Propionyl-CoA: 90.2
CHC-CoA: 77.2
Isobutyryl-CoA: 69.1
Benzoyl-CoA: 46.6
Acetyl-CoA: 41.6
3-Methylbutyryl-CoA: 36.5
fatty_acid: 33.4
inactive: 22.5

nidA5: mal

PKS_AT (565..865): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 215.6
inactive: 108.2
Methoxymalonyl-CoA: 69.7
Methylmalonyl-CoA: 62.5
Propionyl-CoA: 47.3
Isobutyryl-CoA: 37.7
Ethylmalonyl-CoA: 27.1
2-Methylbutyryl-CoA: 24.3
Acetyl-CoA: 19.8
Benzoyl-CoA: 18.7
fatty_acid: 17.4
CHC-CoA: 12.3
trans-1,2-CPDA: 5.6
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor