BGC0000113 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000113 (Streptomyces caelestis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	41,097	niddamycin	PKS	100%

BGC0000113 - Region 1 - T1PKS

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Location: 1 - 41,097 nt. (total: 41,097 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 41,098
Label		BGC0000113

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000113	1.00	Polyketide	niddamycin	Streptomyces caelestis
BGC0000018	0.37	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000041	0.37	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001276	0.33	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0002033	0.33	Polyketide	spiramycin	Streptomyces ambofaciens ATCC 23877
BGC0002452	0.32	Polyketide	leucomycin	Streptomyces kitasatoensis
BGC0000096	0.31	Polyketide	midecamycin	Streptomyces mycarofaciens
BGC0001163	0.31	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001931	0.29	Polyketide	carrimycin	unidentified unclassified sequences.
BGC0001164	0.29	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000113	1.00	Polyketide	niddamycin	Streptomyces caelestis
BGC0000018	0.70	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000041	0.69	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001276	0.67	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0002033	0.67	Polyketide	spiramycin	Streptomyces ambofaciens ATCC 23877
BGC0002452	0.65	Polyketide	leucomycin	Streptomyces kitasatoensis
BGC0000096	0.65	Polyketide	midecamycin	Streptomyces mycarofaciens
BGC0001163	0.64	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001931	0.63	Polyketide	carrimycin	unidentified unclassified sequences.
BGC0001164	0.63	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 41097:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ohmal - ccmal) + (ccmal) + (Me-ohmal - redemal) + (ohmxmal) + (ohmal)
Non-colinear ordering:: nidA1 + nidA2 + nidA3 + nidA4 + nidA5

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

nidA1

PKS_AT (537..828): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 192.2
inactive: 81.9
Methoxymalonyl-CoA: 74.9
Methylmalonyl-CoA: 65.1
Propionyl-CoA: 47.6
Isobutyryl-CoA: 24.1
Ethylmalonyl-CoA: 20.6
2-Methylbutyryl-CoA: 18.8
CHC-CoA: 16.0
Acetyl-CoA: 15.7
fatty_acid: 15.4
trans-1,2-CPDA: 12.4
Benzoyl-CoA: 12.3
3-Methylbutyryl-CoA: 8.8

PKS_AT (1530..1821): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 196.4
inactive: 81.2
Methoxymalonyl-CoA: 72.9
Methylmalonyl-CoA: 64.1
Propionyl-CoA: 42.8
Isobutyryl-CoA: 25.7
Ethylmalonyl-CoA: 20.4
Acetyl-CoA: 17.9
CHC-CoA: 16.2
fatty_acid: 15.2
2-Methylbutyryl-CoA: 13.4
Benzoyl-CoA: 11.9
trans-1,2-CPDA: 8.6
3-Methylbutyryl-CoA: 0.0

PKS_AT (2990..3281): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 202.0
inactive: 87.2
Methoxymalonyl-CoA: 79.4
Methylmalonyl-CoA: 68.1
Propionyl-CoA: 47.9
Isobutyryl-CoA: 29.7
Ethylmalonyl-CoA: 25.3
2-Methylbutyryl-CoA: 20.4
Acetyl-CoA: 18.1
fatty_acid: 16.3
CHC-CoA: 15.3
trans-1,2-CPDA: 12.6
Benzoyl-CoA: 11.9
3-Methylbutyryl-CoA: 0.0

nidA2

PKS_AT (563..854): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.1
inactive: 84.8
Methoxymalonyl-CoA: 76.3
Methylmalonyl-CoA: 65.9
Propionyl-CoA: 47.2
Isobutyryl-CoA: 27.7
Ethylmalonyl-CoA: 23.8
2-Methylbutyryl-CoA: 18.7
Acetyl-CoA: 18.1
fatty_acid: 17.8
CHC-CoA: 15.3
Benzoyl-CoA: 11.9
trans-1,2-CPDA: 11.5
3-Methylbutyryl-CoA: 0.0

nidA3

PKS_AT (569..872): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 214.3
Ethylmalonyl-CoA: 205.4
Methoxymalonyl-CoA: 174.3
2-Methylbutyryl-CoA: 141.0
trans-1,2-CPDA: 119.5
Propionyl-CoA: 118.4
Malonyl-CoA: 113.3
CHC-CoA: 91.8
Isobutyryl-CoA: 87.8
Benzoyl-CoA: 75.1
Acetyl-CoA: 47.8
inactive: 41.5
fatty_acid: 33.0
3-Methylbutyryl-CoA: 32.2

PKS_AT (2009..2306): emal

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Methylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 248.7
Methylmalonyl-CoA: 209.7
Methoxymalonyl-CoA: 188.1
trans-1,2-CPDA: 168.8
2-Methylbutyryl-CoA: 148.2
Propionyl-CoA: 122.6
CHC-CoA: 98.9
Malonyl-CoA: 92.1
Isobutyryl-CoA: 75.0
Benzoyl-CoA: 65.5
Acetyl-CoA: 54.9
fatty_acid: 46.5
3-Methylbutyryl-CoA: 32.6
inactive: 27.8

nidA4

PKS_AT (574..872): mxmal

ATSignature: Methylmalonyl-CoA, Methoxymalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 100.0%; Ethylmalonyl-CoA: 91.7%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 198.1
Ethylmalonyl-CoA: 184.0
Methylmalonyl-CoA: 180.3
trans-1,2-CPDA: 110.3
2-Methylbutyryl-CoA: 99.7
Malonyl-CoA: 92.5
Propionyl-CoA: 90.2
CHC-CoA: 77.2
Isobutyryl-CoA: 69.1
Benzoyl-CoA: 46.6
Acetyl-CoA: 41.6
3-Methylbutyryl-CoA: 36.5
fatty_acid: 33.4
inactive: 22.5

nidA5

PKS_AT (565..865): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 215.6
inactive: 108.2
Methoxymalonyl-CoA: 69.7
Methylmalonyl-CoA: 62.5
Propionyl-CoA: 47.3
Isobutyryl-CoA: 37.7
Ethylmalonyl-CoA: 27.1
2-Methylbutyryl-CoA: 24.3
Acetyl-CoA: 19.8
Benzoyl-CoA: 18.7
fatty_acid: 17.4
CHC-CoA: 12.3
trans-1,2-CPDA: 5.6
3-Methylbutyryl-CoA: 0.0