BGC0000114 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000114 (Streptomyces violaceusniger)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	95,700	nigericin	PKS:Type I	100%

BGC0000114 - Region 1 - T1PKS

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Location: 1 - 95,700 nt. (total: 95,700 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 95,701
Label		BGC0000114

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000114	1.00	Polyketide	nigericin	Streptomyces violaceusniger
BGC0002038	0.42	Polyketide	nigericin	Streptomyces sp. DASNCL29
BGC0001164	0.34	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001163	0.32	Polyketide	1-heptadecene	Moorea producens 3L
BGC0002729	0.32	Polyketide	sordarial	Neurospora crassa OR74A
BGC0002266	0.32	Terpene, Polyketide	calidoustene A, calidoustene B, calidoustene C	Aspergillus calidoustus
BGC0002228	0.32	NRP	CIML B, CIML A, CIML D, CIML C	Colletotrichum incanum
BGC0002211	0.32	Polyketide	HEx-pks1 polyketide	Paraphaeosphaeria sporulosa
BGC0000353	0.32	NRP	tacrolimus	Streptomyces sp. MA6548
BGC0002234	0.31	Polyketide	flavoglaucin	Aspergillus ruber CBS 135680

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000114	1.00	Polyketide	nigericin	Streptomyces violaceusniger
BGC0002038	0.73	Polyketide	nigericin	Streptomyces sp. DASNCL29
BGC0001164	0.67	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001163	0.65	Polyketide	1-heptadecene	Moorea producens 3L
BGC0002729	0.65	Polyketide	sordarial	Neurospora crassa OR74A
BGC0002266	0.65	Terpene, Polyketide	calidoustene A, calidoustene B, calidoustene C	Aspergillus calidoustus
BGC0002228	0.65	NRP	CIML B, CIML A, CIML D, CIML C	Colletotrichum incanum
BGC0002211	0.65	Polyketide	HEx-pks1 polyketide	Paraphaeosphaeria sporulosa
BGC0000353	0.65	NRP	tacrolimus	Streptomyces sp. MA6548
BGC0002234	0.65	Polyketide	flavoglaucin	Aspergillus ruber CBS 135680

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 95700:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-mal) + (Me-redmal) + (ccmal - Me-redmal) + (Me-ccmal - redmal) + (Me-ccmal - Me-redmal) + (Me-ohmal) + (ohmal - ohmal - ohmal) + (Me-redmal) + (Me-ccmal)
Non-colinear ordering:: ABC84456.1 + ABC84457.1 + ABC84458.1 + ABC84459.1 + ABC84460.1 + ABC84461.1 + ABC84471.1 + ABC84470.1 + ABC84469.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ABC84456.1

PKS_AT (541..848): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.5
inactive: 92.1
Methoxymalonyl-CoA: 72.7
Methylmalonyl-CoA: 63.0
Isobutyryl-CoA: 42.1
Ethylmalonyl-CoA: 28.9
Acetyl-CoA: 28.7
Propionyl-CoA: 27.0
Benzoyl-CoA: 26.8
CHC-CoA: 17.7
fatty_acid: 13.3
3-Methylbutyryl-CoA: 13.2
2-Methylbutyryl-CoA: 9.8
trans-1,2-CPDA: -0.3

PKS_AT (1577..1880): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 197.9
Ethylmalonyl-CoA: 191.3
Methoxymalonyl-CoA: 167.0
trans-1,2-CPDA: 129.9
2-Methylbutyryl-CoA: 126.0
Propionyl-CoA: 111.3
Malonyl-CoA: 94.3
CHC-CoA: 92.5
Isobutyryl-CoA: 70.3
fatty_acid: 44.8
Benzoyl-CoA: 44.8
Acetyl-CoA: 31.2
3-Methylbutyryl-CoA: 24.8
inactive: 16.9

ABC84457.1

PKS_AT (566..869): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.7
Ethylmalonyl-CoA: 206.8
Methoxymalonyl-CoA: 174.4
trans-1,2-CPDA: 135.7
2-Methylbutyryl-CoA: 131.2
Propionyl-CoA: 111.4
Malonyl-CoA: 110.8
CHC-CoA: 108.4
Isobutyryl-CoA: 73.3
Benzoyl-CoA: 68.8
fatty_acid: 48.0
Acetyl-CoA: 46.1
3-Methylbutyryl-CoA: 36.4
inactive: 20.9

ABC84458.1

PKS_AT (596..895): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 225.2
inactive: 119.9
Methoxymalonyl-CoA: 55.2
Methylmalonyl-CoA: 44.0
Propionyl-CoA: 29.1
Isobutyryl-CoA: 27.1
Acetyl-CoA: 22.8
Benzoyl-CoA: 16.3
Ethylmalonyl-CoA: 10.5
2-Methylbutyryl-CoA: 8.5
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2398..2701): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 213.4
Ethylmalonyl-CoA: 206.9
Methoxymalonyl-CoA: 177.5
trans-1,2-CPDA: 149.4
2-Methylbutyryl-CoA: 140.3
Propionyl-CoA: 121.6
Malonyl-CoA: 109.7
CHC-CoA: 97.6
Isobutyryl-CoA: 70.9
Benzoyl-CoA: 58.5
Acetyl-CoA: 56.3
fatty_acid: 53.3
3-Methylbutyryl-CoA: 32.4
inactive: 24.8

ABC84459.1

PKS_AT (565..865): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 211.2
Ethylmalonyl-CoA: 208.1
Methoxymalonyl-CoA: 175.4
trans-1,2-CPDA: 138.3
2-Methylbutyryl-CoA: 133.7
Propionyl-CoA: 115.1
CHC-CoA: 114.0
Malonyl-CoA: 108.2
Isobutyryl-CoA: 66.7
Benzoyl-CoA: 65.0
Acetyl-CoA: 51.0
fatty_acid: 50.3
3-Methylbutyryl-CoA: 37.5
inactive: 27.0

PKS_AT (2364..2656): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 179.2
inactive: 95.5
Methylmalonyl-CoA: 63.2
Methoxymalonyl-CoA: 61.2
fatty_acid: 37.2
Isobutyryl-CoA: 36.3
Propionyl-CoA: 34.5
2-Methylbutyryl-CoA: 26.8
Acetyl-CoA: 22.9
Ethylmalonyl-CoA: 21.0
trans-1,2-CPDA: 14.3
CHC-CoA: 14.2
Benzoyl-CoA: 7.9
3-Methylbutyryl-CoA: 0.0

ABC84460.1

PKS_AT (565..865): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 211.2
Ethylmalonyl-CoA: 203.6
Methoxymalonyl-CoA: 174.4
trans-1,2-CPDA: 141.4
2-Methylbutyryl-CoA: 133.5
Propionyl-CoA: 108.5
Malonyl-CoA: 106.5
CHC-CoA: 102.7
Isobutyryl-CoA: 72.8
Benzoyl-CoA: 68.6
fatty_acid: 43.0
3-Methylbutyryl-CoA: 41.7
Acetyl-CoA: 40.8
inactive: 21.9

PKS_AT (2374..2677): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.9
Ethylmalonyl-CoA: 206.5
Methoxymalonyl-CoA: 173.7
trans-1,2-CPDA: 145.1
2-Methylbutyryl-CoA: 127.4
Propionyl-CoA: 110.3
Malonyl-CoA: 108.4
CHC-CoA: 94.3
Isobutyryl-CoA: 70.2
Benzoyl-CoA: 57.4
Acetyl-CoA: 42.6
fatty_acid: 40.0
3-Methylbutyryl-CoA: 23.9
inactive: 21.9

ABC84461.1

PKS_AT (588..888): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 205.5
Ethylmalonyl-CoA: 203.6
Methoxymalonyl-CoA: 174.7
2-Methylbutyryl-CoA: 127.4
trans-1,2-CPDA: 123.2
Propionyl-CoA: 106.5
Malonyl-CoA: 103.0
CHC-CoA: 90.4
Isobutyryl-CoA: 64.7
Benzoyl-CoA: 46.8
Acetyl-CoA: 40.1
fatty_acid: 37.5
3-Methylbutyryl-CoA: 22.4
inactive: 21.3

ABC84469.1

PKS_AT (576..876): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 205.7
Ethylmalonyl-CoA: 196.7
Methoxymalonyl-CoA: 170.3
2-Methylbutyryl-CoA: 149.3
trans-1,2-CPDA: 127.3
Propionyl-CoA: 122.1
Malonyl-CoA: 97.7
CHC-CoA: 97.0
Isobutyryl-CoA: 70.9
fatty_acid: 51.6
Acetyl-CoA: 47.4
Benzoyl-CoA: 46.3
3-Methylbutyryl-CoA: 40.5
inactive: 17.1

ABC84470.1

PKS_AT (578..878): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 204.4
Ethylmalonyl-CoA: 192.1
Methoxymalonyl-CoA: 170.7
2-Methylbutyryl-CoA: 146.8
trans-1,2-CPDA: 123.3
Propionyl-CoA: 120.8
Malonyl-CoA: 102.2
CHC-CoA: 89.4
Isobutyryl-CoA: 71.1
fatty_acid: 52.5
Benzoyl-CoA: 48.7
Acetyl-CoA: 43.6
3-Methylbutyryl-CoA: 36.6
inactive: 17.2

ABC84471.1

PKS_AT (577..876): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 167.2
inactive: 76.0
Methoxymalonyl-CoA: 62.5
Methylmalonyl-CoA: 53.7
fatty_acid: 31.2
Propionyl-CoA: 28.4
Isobutyryl-CoA: 23.7
2-Methylbutyryl-CoA: 21.1
Ethylmalonyl-CoA: 21.0
Acetyl-CoA: 20.9
trans-1,2-CPDA: 11.3
Benzoyl-CoA: 9.2
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2145..2448): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 168.4
inactive: 72.2
Methoxymalonyl-CoA: 62.8
Methylmalonyl-CoA: 51.6
Propionyl-CoA: 31.7
fatty_acid: 31.3
Isobutyryl-CoA: 22.2
Ethylmalonyl-CoA: 17.2
2-Methylbutyryl-CoA: 15.9
Acetyl-CoA: 15.1
trans-1,2-CPDA: 9.6
Benzoyl-CoA: 9.2
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (3696..3989): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 164.3
inactive: 71.5
Methoxymalonyl-CoA: 60.7
Methylmalonyl-CoA: 50.9
fatty_acid: 31.8
Propionyl-CoA: 29.6
Ethylmalonyl-CoA: 20.6
Isobutyryl-CoA: 18.8
Acetyl-CoA: 17.6
2-Methylbutyryl-CoA: 14.2
trans-1,2-CPDA: 9.2
Benzoyl-CoA: 9.1
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0