Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000114.1:
Cluster 1Polyketide195700

BGC0000114, nigericin biosynthetic gene cluster from Streptomyces violaceusniger. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: nigericin
PubChem ID: 34230
SMILES string: Copy to clipboard
Molecular formula: C40H68O11
Average molecular mass: 724.973 Da
Molecular activity: Other
Molecular target: metal ion

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Polyether (linear)
Polyketide synthase subclass:
Modular type I
Starter unit:
Acetyl-CoA
Thioesterase type:
Other
Release / cyclization type:
Hydrolysis

Gene cluster description

nigericin (BGC0000114). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank Not derived from GenBank. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Gene expression correlated with compound production, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Zhen Qi (Shanghai Jiao Tong University)

Literature references

1. Harvey BM et al. (2007) Insights into polyether biosynthesis from analysis of the nigericin biosynthetic gene cluster in Streptomyces sp. DSM4137. Chem Biol 14(6):703-14. doi: 10.1016/j.chembiol.2007.05.011.