BGC0000115 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000115 (Streptomyces noursei ATCC 11455)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	123,580	nystatin A1	PKS:Type I+saccharide:hybrid/tailoring	100%

BGC0000115 - Region 1 - T1PKS

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Location: 1 - 123,580 nt. (total: 123,580 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 123,581
Label		BGC0000115

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000115	1.00	Polyketide, Saccharide	nystatin A1	Streptomyces noursei ATCC 11455
BGC0001709	0.60	Polyketide	nystatin	Streptomyces albulus
BGC0000041	0.46	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000016	0.40	Other	amphotericin B	Streptomyces nodosus
BGC0000116	0.35	Polyketide	nystatin-like Pseudonocardia polyene	Pseudonocardia autotrophica
BGC0000844	0.35	Other	clavulanic acid	Streptomyces clavuligerus
BGC0002031	0.33	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0001647	0.33	Polyketide	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18
BGC0002099	0.32	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0002084	0.32	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000115	1.00	Polyketide, Saccharide	nystatin A1	Streptomyces noursei ATCC 11455
BGC0001709	0.84	Polyketide	nystatin	Streptomyces albulus
BGC0000041	0.76	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000016	0.72	Other	amphotericin B	Streptomyces nodosus
BGC0000116	0.68	Polyketide	nystatin-like Pseudonocardia polyene	Pseudonocardia autotrophica
BGC0000844	0.68	Other	clavulanic acid	Streptomyces clavuligerus
BGC0002031	0.66	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0001647	0.66	Polyketide	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18
BGC0002099	0.65	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0002084	0.65	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 123580:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (Me-ohmal - Me-ohmal) + (ccmal - ccmal - redmal - ccmal - ccmal - ccmal) + (ccmal - ohmal - Me-ohmal - ohmal - ohmal - ohmal) + (redmal - ohmal - ccmal) + (ccmal)
Non-colinear ordering:: nysA + nysB + nysC + nysI + nysJ + nysK

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

nysI

PKS_AT (570..866): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 215.4
inactive: 112.7
Methoxymalonyl-CoA: 52.7
Methylmalonyl-CoA: 40.9
Acetyl-CoA: 20.4
Benzoyl-CoA: 15.2
Ethylmalonyl-CoA: 14.7
Isobutyryl-CoA: 11.2
CHC-CoA: 9.7
trans-1,2-CPDA: 6.6
Propionyl-CoA: 1.3
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: -1.3

PKS_AT (2344..2640): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 227.8
inactive: 90.8
Methoxymalonyl-CoA: 68.2
Methylmalonyl-CoA: 60.5
Ethylmalonyl-CoA: 37.4
Isobutyryl-CoA: 28.8
Propionyl-CoA: 28.4
Benzoyl-CoA: 23.5
Acetyl-CoA: 22.6
CHC-CoA: 17.2
2-Methylbutyryl-CoA: 16.3
fatty_acid: 12.9
trans-1,2-CPDA: 9.1
3-Methylbutyryl-CoA: 0.0

PKS_AT (3896..4194): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 217.4
Ethylmalonyl-CoA: 212.3
Methoxymalonyl-CoA: 175.8
2-Methylbutyryl-CoA: 142.5
trans-1,2-CPDA: 129.6
Propionyl-CoA: 118.4
CHC-CoA: 103.0
Malonyl-CoA: 91.3
Isobutyryl-CoA: 90.7
Benzoyl-CoA: 69.3
Acetyl-CoA: 49.0
3-Methylbutyryl-CoA: 49.0
fatty_acid: 37.9
inactive: 24.8

PKS_AT (5430..5729): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 220.4
inactive: 109.2
Methoxymalonyl-CoA: 60.9
Methylmalonyl-CoA: 47.2
Propionyl-CoA: 29.2
Acetyl-CoA: 20.8
Benzoyl-CoA: 15.9
CHC-CoA: 12.2
Isobutyryl-CoA: 12.0
fatty_acid: 11.8
2-Methylbutyryl-CoA: 9.5
Ethylmalonyl-CoA: 4.8
trans-1,2-CPDA: 1.6
3-Methylbutyryl-CoA: 0.0

PKS_AT (6971..7269): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 231.5
inactive: 110.8
Methoxymalonyl-CoA: 68.8
Methylmalonyl-CoA: 62.0
Propionyl-CoA: 37.1
2-Methylbutyryl-CoA: 25.0
Isobutyryl-CoA: 24.3
Ethylmalonyl-CoA: 23.1
Benzoyl-CoA: 20.3
Acetyl-CoA: 13.2
CHC-CoA: 11.3
fatty_acid: 6.4
trans-1,2-CPDA: 4.6
3-Methylbutyryl-CoA: 0.0

PKS_AT (8428..8718): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 228.5
inactive: 114.9
Methoxymalonyl-CoA: 60.7
Methylmalonyl-CoA: 53.7
Isobutyryl-CoA: 31.5
Ethylmalonyl-CoA: 28.9
Propionyl-CoA: 27.6
Benzoyl-CoA: 21.7
Acetyl-CoA: 21.4
CHC-CoA: 16.4
2-Methylbutyryl-CoA: 14.9
trans-1,2-CPDA: 12.0
fatty_acid: 9.2
3-Methylbutyryl-CoA: 0.0

nysJ

PKS_AT (576..864): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 230.5
inactive: 104.5
Methoxymalonyl-CoA: 61.0
Methylmalonyl-CoA: 49.5
Propionyl-CoA: 22.0
Benzoyl-CoA: 18.5
Ethylmalonyl-CoA: 18.4
Isobutyryl-CoA: 16.0
Acetyl-CoA: 14.8
CHC-CoA: 9.3
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: -0.7

PKS_AT (2633..2929): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 213.4
inactive: 103.4
Methoxymalonyl-CoA: 51.6
Methylmalonyl-CoA: 51.2
Isobutyryl-CoA: 27.9
Propionyl-CoA: 21.6
Benzoyl-CoA: 12.5
Ethylmalonyl-CoA: 8.9
CHC-CoA: 7.5
Acetyl-CoA: 4.5
2-Methylbutyryl-CoA: 2.3
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (4151..4448): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 213.4
inactive: 103.4
Methoxymalonyl-CoA: 51.6
Methylmalonyl-CoA: 51.2
Isobutyryl-CoA: 27.9
Propionyl-CoA: 21.6
Benzoyl-CoA: 12.5
Ethylmalonyl-CoA: 8.9
CHC-CoA: 7.5
Acetyl-CoA: 4.5
2-Methylbutyryl-CoA: 2.3
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

nysK

PKS_AT (566..857): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 208.5
inactive: 85.6
Methoxymalonyl-CoA: 60.8
Methylmalonyl-CoA: 49.4
Propionyl-CoA: 22.1
Isobutyryl-CoA: 21.1
CHC-CoA: 17.4
Ethylmalonyl-CoA: 16.4
2-Methylbutyryl-CoA: 15.2
Benzoyl-CoA: 11.7
Acetyl-CoA: 8.2
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0
trans-1,2-CPDA: -0.6

nysA

PKS_AT (526..817): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 218.3
inactive: 94.0
Methoxymalonyl-CoA: 63.6
Methylmalonyl-CoA: 53.8
Isobutyryl-CoA: 32.1
Ethylmalonyl-CoA: 28.3
Benzoyl-CoA: 25.5
CHC-CoA: 20.2
Acetyl-CoA: 17.9
Propionyl-CoA: 16.2
trans-1,2-CPDA: 7.8
2-Methylbutyryl-CoA: 1.7
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

nysB

PKS_AT (576..874): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 216.0
Ethylmalonyl-CoA: 210.5
Methoxymalonyl-CoA: 173.3
2-Methylbutyryl-CoA: 139.4
trans-1,2-CPDA: 124.9
Propionyl-CoA: 117.0
CHC-CoA: 101.2
Malonyl-CoA: 89.4
Isobutyryl-CoA: 85.3
Benzoyl-CoA: 64.9
3-Methylbutyryl-CoA: 43.9
Acetyl-CoA: 41.8
fatty_acid: 32.3
inactive: 24.5

PKS_AT (2115..2416): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 212.8
Ethylmalonyl-CoA: 202.9
Methoxymalonyl-CoA: 177.7
2-Methylbutyryl-CoA: 140.5
trans-1,2-CPDA: 138.8
Propionyl-CoA: 114.9
CHC-CoA: 112.9
Malonyl-CoA: 106.7
Isobutyryl-CoA: 79.4
Benzoyl-CoA: 66.6
fatty_acid: 50.6
Acetyl-CoA: 45.1
3-Methylbutyryl-CoA: 37.9
inactive: 25.0

nysC

PKS_AT (544..834): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 227.9
inactive: 103.2
Methoxymalonyl-CoA: 62.7
Methylmalonyl-CoA: 51.1
Propionyl-CoA: 34.6
CHC-CoA: 20.7
Acetyl-CoA: 19.1
Ethylmalonyl-CoA: 18.1
Benzoyl-CoA: 17.7
Isobutyryl-CoA: 16.5
2-Methylbutyryl-CoA: 15.0
fatty_acid: 12.4
trans-1,2-CPDA: 7.3
3-Methylbutyryl-CoA: 0.0

PKS_AT (2289..2579): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 240.3
inactive: 117.1
Methoxymalonyl-CoA: 64.5
Methylmalonyl-CoA: 60.6
Isobutyryl-CoA: 34.3
Propionyl-CoA: 33.8
Benzoyl-CoA: 24.3
Ethylmalonyl-CoA: 23.8
Acetyl-CoA: 20.1
2-Methylbutyryl-CoA: 19.9
CHC-CoA: 15.1
trans-1,2-CPDA: 12.4
fatty_acid: 9.8
3-Methylbutyryl-CoA: 0.0

PKS_AT (4030..4322): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 240.3
inactive: 105.1
Methoxymalonyl-CoA: 63.7
Methylmalonyl-CoA: 54.7
Propionyl-CoA: 36.1
Ethylmalonyl-CoA: 28.7
Isobutyryl-CoA: 24.6
Acetyl-CoA: 20.8
Benzoyl-CoA: 19.3
CHC-CoA: 15.7
2-Methylbutyryl-CoA: 12.3
fatty_acid: 9.6
trans-1,2-CPDA: 9.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (6164..6455): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 240.4
inactive: 103.0
Methoxymalonyl-CoA: 53.4
Methylmalonyl-CoA: 51.6
Propionyl-CoA: 37.5
Ethylmalonyl-CoA: 23.4
Acetyl-CoA: 20.9
Benzoyl-CoA: 20.3
2-Methylbutyryl-CoA: 16.8
Isobutyryl-CoA: 16.3
CHC-CoA: 11.8
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (7937..8229): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 243.2
inactive: 104.5
Methoxymalonyl-CoA: 62.0
Methylmalonyl-CoA: 56.3
Propionyl-CoA: 37.2
Ethylmalonyl-CoA: 26.9
Isobutyryl-CoA: 24.3
Benzoyl-CoA: 21.6
Acetyl-CoA: 20.7
2-Methylbutyryl-CoA: 19.2
CHC-CoA: 13.2
trans-1,2-CPDA: 10.5
fatty_acid: 9.2
3-Methylbutyryl-CoA: 0.0

PKS_AT (9756..10048): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 236.9
inactive: 104.5
Methylmalonyl-CoA: 54.3
Methoxymalonyl-CoA: 53.4
Propionyl-CoA: 37.1
Ethylmalonyl-CoA: 27.3
Acetyl-CoA: 22.6
Benzoyl-CoA: 19.4
Isobutyryl-CoA: 18.0
2-Methylbutyryl-CoA: 17.1
CHC-CoA: 16.6
trans-1,2-CPDA: 12.5
fatty_acid: 9.1
3-Methylbutyryl-CoA: 0.0