BGC0000115: nystatin A1 biosynthetic gene cluster from Streptomyces noursei ATCC 11455
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Location: 1 - 123,580 nt. (total: 123,580 nt).
This entry is originally from NCBI GenBank AF263912.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000115
Short description nystatin A1 biosynthetic gene cluster from Streptomyces noursei ATCC 11455
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
  • saccharide (hybrid/tailoring)
Loci
AF263912.1
via Knock-out studies
Compounds
  • nystatin A1
Species Streptomyces noursei ATCC 11455 [taxonomy]
References
Chemical products information
nystatin A1 Evidence:
Copy SMILES
C47H75N1O17
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAF71762.1
  • nysF
 46 - 783 (-) nysF
  • Activation / processing
  • Knock-out
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  • AAF71763.1
  • nysG
 867 - 2684 (-) nysG
  • Transport
  • Knock-out
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  • AAF71764.1
  • nysH
 2662 - 4416 (-) nysH
  • Transport
  • Knock-out
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  • AAF71765.1
  • nysDIII
 4714 - 5748 (+) nysDIII
  • Precursor biosynthesis
  • Activity assay
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  • AAF71766.1
  • nysI
 5930 - 34363 (+) nysI
  • Scaffold biosynthesis
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  • AAF71767.1
  • nysJ
 34384 - 50691 (+) nysJ
  • Scaffold biosynthesis
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  • AAF71768.1
  • nysK
 50747 - 56947 (+) nysK
  • Scaffold biosynthesis
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  • AAF71769.1
  • nysL
 57095 - 58279 (+) nysL
  • Tailoring
  • Activity assay
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  • AAF71770.1
  • nysM
 58378 - 58572 (-) nysM
  • Activation / processing
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  • AAF71771.1
  • nysN
 58637 - 59833 (-) nysN
  • Tailoring
  • Knock-out
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  • AAF71772.1
  • nysDII
 59830 - 60888 (-) nysDII
  • Precursor biosynthesis
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  • AAF71773.1
  • nysDI
 60909 - 62429 (-) nysDI
  • Tailoring
  • Knock-out
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  • AAF71774.1
  • nysA
 62659 - 66759 (+) nysA
  • Scaffold biosynthesis
  • Knock-out
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  • AAF71775.1
  • nysB
 66805 - 76383 (+) nysB
  • Scaffold biosynthesis
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  • AAF71776.1
  • nysC
 76403 - 109693 (+) nysC
  • Scaffold biosynthesis
  • Knock-out
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  • AAF71777.1
  • nysE
 110113 - 110868 (+) nysE
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    • AAF71778.1
    • nysRI
    		 111258 - 114158 (+) nysRI
    • Regulation
    • Knock-out
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    • AAF71779.1
    • nysRII
    		 114182 - 117043 (+) nysRII
    • Regulation
    • Knock-out
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    • AAF71780.1
    • nysRIII
    		 117033 - 119816 (+) nysRIII
    • Regulation
    • Knock-out
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    • AAF71781.1
    		 120268 - 120900 (+) ORF4
    • Regulation
    • Knock-out
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    • AAF71782.1
    		 121589 - 122350 (+) ORF3
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      • AAF71783.1
      		 122404 - 123468 (-) ORF2
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        Biosynthesis information

        Biosynthetic modules

        Name
        1
        Type
        pks-modular
        Genes
        nysA
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, dehydratase, carrier (ACP)
        Name
        2
        Type
        pks-modular
        Genes
        nysB
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
        Name
        3
        Type
        pks-modular
        Genes
        nysB
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
        Name
        4
        Type
        pks-modular
        Genes
        nysC
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
        Name
        5
        Type
        pks-modular
        Genes
        nysC
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
        Name
        6
        Type
        pks-modular
        Genes
        nysC
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
        Name
        7
        Type
        pks-modular
        Genes
        nysC
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
        Name
        8
        Type
        pks-modular
        Genes
        nysC
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
        Name
        9
        Type
        pks-modular
        Genes
        nysC
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
        Name
        10
        Type
        pks-modular
        Genes
        nysI
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
        Name
        11
        Type
        pks-modular
        Genes
        nysI
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
        Name
        12
        Type
        pks-modular
        Genes
        nysI
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
        Name
        13
        Type
        pks-modular
        Genes
        nysI
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
        Name
        14
        Type
        pks-modular
        Genes
        nysI
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
        Name
        15
        Type
        pks-modular
        Genes
        nysI
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
        Name
        16
        Type
        pks-modular
        Genes
        nysJ
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, carrier (ACP)
        Name
        17
        Type
        pks-modular
        Genes
        nysJ
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
        Name
        18
        Type
        pks-modular
        Genes
        nysJ
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
        Name
        19
        Type
        pks-modular
        Genes
        nysK
        Substrates
        Integrated Monomers
        Domains
        acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, thioesterase, carrier (ACP)
        Annotation changelog

        Entry version: 4

        Date
        Changes
        Submitters
        Reviewers
        2022-10-07
        Update chemical activity to schema version 2.11
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 3

        Date
        Changes
        Submitters
        Reviewers
        2022-09-15
        Removed gene names of 'No gene ID'
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2022-09-15
        Removed ketoreductase stereochemistry annotation from modules without ketoreductases
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2022-09-15
        Sorted modules by module number
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 2

        Date
        Changes
        Submitters
        Reviewers
        2019-10-16
        Migrated from v1.4
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 1

        Date
        Changes
        Submitters
        Reviewers
        2015-06-12
        Submitted
        • (ID: MU4LZLKCEF7Q67JF6ZEMKX3R)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        Detailed domain annotation
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