BGC0000119: 7-deoxypactamycin biosynthetic gene cluster from Streptomyces pactum
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Location: 1 - 86,350 nt. (total: 86,350 nt).
This entry is originally from NCBI GenBank FJ392609.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
Saccharide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000119
Short description 7-deoxypactamycin biosynthetic gene cluster from Streptomyces pactum
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
  • Saccharide (hybrid/tailoring)
Loci NCBI GenBank: FJ392609.1
Compounds
  • 7-deoxypactamycin
Species Streptomyces pactum [taxonomy]
References
Chemical products information
7-deoxypactamycin
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C28H38N4O7
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACJ24841.1
 2 - 1489 (+) phosphoribosylformylglycinamidine synthase II-like protein
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  • ACJ24842.1
 1756 - 2643 (+) hypothetical protein
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  • ACJ24843.1
 2803 - 4377 (-) n-acetylgalactosamine-6-sulfate sulfatase-like protein
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  • ACJ24844.1
 5443 - 7026 (+) amidophosphoribosyltransferase-like protein
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  • ACJ24845.1
 7060 - 8160 (+) phosphoribosylaminoimidazole synthetase-like protein
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  • ACJ24846.1
 9066 - 10160 (-) valine dehydrogenase (NADP+)-like protein
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  • ACJ24847.1
 10461 - 11279 (+) hypothetical protein
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  • ACJ24848.1
 12500 - 13135 (-) hypothetical protein
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  • ACJ24849.1
 14199 - 18185 (-) ATP-dependent helicase-like protein
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  • ACJ24850.1
 18815 - 19801 (+) integral membrane protein
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  • ACJ24851.1
 19889 - 21616 (+) putative ECF-family RNA polymerase sigma factor
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  • ACJ24852.1
 21753 - 22910 (+) putative FAD-dependent pyridine nucleotide-disulphide oxidoreductase
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  • ACJ24853.1
 23582 - 24052 (+) hypothetical protein
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  • ACJ24854.1
 24165 - 24932 (+) putative translation initiation factor IF-2
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  • ACJ24855.1
 25050 - 25502 (+) putative translation initiation factor IF-2
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  • ACJ24856.1
 25602 - 27968 (+) putative ATP-dependent RNA helicase
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  • ACJ24857.1
  • ptmY
 29893 - 31086 (-) putative cytochrome P450 monooxygenase
  • Tailoring (Hydroxylation)
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  • ACJ24858.1
  • ptmZ
 31140 - 31628 (-) glutathione peroxidase-like protein
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  • ACJ24859.1
  • ptmA
 31845 - 33020 (-) L-alanine:N-amidino-3-keto-scyllo-inosamine aminotransferase-like protein
  • Scaffold biosynthesis
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  • ACJ24860.1
  • ptmB
 33035 - 34747 (-) putative carbamoyltransferase
  • Tailoring (Carboxylation)
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  • ACJ24861.1
  • ptmC
 35020 - 36123 (+) Fe-S radical SAM oxidoreductase-like protein
  • Scaffold biosynthesis
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  • ACJ24862.1
  • ptmD
 36189 - 37265 (+) HemK family methyltransferase
  • Tailoring (Methylation)
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  • ACJ24863.1
  • ptmE
 37258 - 37794 (-) putative glucokinase
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  • ACJ24864.1
  • ptmF
 37794 - 38444 (-) two component transcriptional regulator
  • Regulation
Sequence-based prediction
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  • ACJ24865.1
  • ptmG
 38620 - 39756 (-) putative nucleotydyltransferase
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  • ACJ24866.1
  • ptmH
 40175 - 42160 (+) putative C-methyltransferase
  • Tailoring (Methylation)
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  • ACJ24867.1
  • ptmI
 42192 - 42476 (+) putative acyl carrier protein
  • Scaffold biosynthesis
Sequence-based prediction
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  • ACJ24868.1
  • ptmJ
 42482 - 43438 (+) putative glycosyltransferase
  • Scaffold biosynthesis
Activity assay
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  • ACJ24869.1
  • ptmK
 43435 - 45123 (+) putative ketoacyl-ACP synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • ACJ24870.1
  • ptmL
 45116 - 46843 (+) putative C-methyltransferase
  • Tailoring (Methylation)
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  • ACJ24871.1
  • ptmM
 46894 - 48630 (+) putative C-methyltransferase
  • Tailoring (Methylation)
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  • ACJ24872.1
  • ptmN
 48634 - 49689 (+) putative NAD dependent dehydrogenase
  • Scaffold biosynthesis
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  • ACJ24873.1
  • ptmO
 50000 - 50773 (-) putative hydrolase/acyltransferase
  • Scaffold biosynthesis
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  • ACJ24874.1
  • ptmP
 50883 - 51518 (+) phosphopantetheinyl transferase
  • Activation / processing
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  • ACJ24875.1
  • ptmQ
 52474 - 58059 (-) 6-methylsalicylic acid synthase
  • Precursor biosynthesis
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  • ACJ24876.1
  • ptmR
 58056 - 59129 (-) ketoacyl-ACP synthase
  • Precursor biosynthesis
Sequence-based prediction
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  • ACJ24877.1
  • ptmS
 59143 - 60660 (-) putative AMP-forming acyl-CoA synthetase
  • Scaffold biosynthesis
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  • ACJ24878.1
  • ptmT
 60657 - 61991 (-) glutamate-1-semialdehyde aminotransferase-like protein
  • Precursor biosynthesis
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  • ACJ24879.1
  • ptmU
 62153 - 62992 (+) putative short-chain dehydrogenase/reductase
  • Scaffold biosynthesis
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  • ACJ24880.1
  • ptmV
 63030 - 63710 (+) putative phosphatase
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  • ACJ24881.1
  • ptmW
 64635 - 65450 (+) hypothetical protein
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  • ACJ24882.1
  • ptmX
 66186 - 67481 (+) integral membrane protein
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  • ACJ24883.1
 67855 - 69201 (+) putative peptidase
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  • ACJ24884.1
 69778 - 70359 (+) nourseothricin acetyltransferase-like protein
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  • ACJ24885.1
 70343 - 73474 (-) putative ATP-dependent helicase
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  • ACJ24886.1
 73641 - 74723 (+) hypothetical protein
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  • ACJ24887.1
 74737 - 76386 (-) hypothetical protein
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  • ACJ24888.1
 76463 - 76867 (+) glycosyl transferase family 51
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  • ACJ24889.1
 77327 - 78619 (-) putative methyltransferase
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  • ACJ24890.1
 78767 - 79951 (-) hypothetical protein
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  • ACJ24891.1
 80490 - 81968 (-) sporulation associated protein
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  • ACJ24892.1
 82831 - 84993 (+) putative secreted protein
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  • ACJ24893.1
 85154 - >86350 (+) multi-domain regulatory protein
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
ptmQ Synthase subclass: Iterative type I
Iterative PKS type: Partially reducing, C2-C7 first
Iteration counts: 3
Saccharide-specific information
Subclass hybrid/tailoring
Glycosyltransferases
ptmJ
Evidence:
  • Sequence-based prediction
ACJ24888.1
Evidence:
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: ZV4PLWZMKXHKHM6T5Z6RFAE3, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added version numbers to protein accessions
  • Removed duplicate gene name
  • Corrected gene identifiers
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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