BGC0000119 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000119 (Streptomyces pactum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	arylpolyene,T1PKS,PKS-like	1	86,350	7-deoxypactamycin	PKS:Iterative type I+saccharide:hybrid/tailoring	100%

BGC0000119 - Region 1 - PKS-like,T1PKS,arylpolyene

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Location: 1 - 86,350 nt. (total: 86,350 nt) Show pHMM detection rules used

Region on contig edge.

arylpolyene: (APE_KS1 or APE_KS2)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
PKS-like: (t2pks2 or ksIII)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 86,351
Label		BGC0000119

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000119	2.60	Polyketide, Saccharide	7-deoxypactamycin	Streptomyces pactum
BGC0000118	2.43	Polyketide	pactamycin	Streptomyces pactum
BGC0001275	1.02	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273	1.02	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001244	1.00	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001444	0.95	Other (shikimate derived)	caboxamycin	Streptomyces sp. NTK 937
BGC0000996	0.89	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0002615	0.88	Terpene	4-oxomacrophorin A, macrophorin A, 5'-epimacrophorin B	Penicillium terrestre
BGC0000836	0.88	Other	APE Ec	Escherichia coli CFT073
BGC0000170	0.88	Polyketide	yanuthone D	Aspergillus niger ATCC 1015

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000119	1.00	Polyketide, Saccharide	7-deoxypactamycin	Streptomyces pactum
BGC0000118	1.00	Polyketide	pactamycin	Streptomyces pactum
BGC0001275	0.67	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273	0.67	Polyketide	asperlactone	Aspergillus ochraceus
BGC0002031	0.67	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0002631	0.67	RiPP	myxarylin	Pyxidicoccus fallax
BGC0001244	0.66	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0000820	0.66	Alkaloid	physostigmine	Streptomyces griseofuscus
BGC0001444	0.65	Other (shikimate derived)	caboxamycin	Streptomyces sp. NTK 937
BGC0000996	0.64	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 23434 - 79129:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-ccmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 23434 - 65123:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-ccmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 32473 - 79129:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-ccmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ptmQ

PKS_AT (643..937): mmal

ATSignature: Methylmalonyl-CoA, Malonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 70.8%; Malonyl-CoA: 70.8%; Ethylmalonyl-CoA: 66.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 116.1
Ethylmalonyl-CoA: 92.1
Methoxymalonyl-CoA: 90.6
Malonyl-CoA: 78.7
Propionyl-CoA: 53.0
trans-1,2-CPDA: 52.5
Isobutyryl-CoA: 48.1
2-Methylbutyryl-CoA: 44.9
fatty_acid: 38.7
Benzoyl-CoA: 31.5
Acetyl-CoA: 27.9
inactive: 26.5
CHC-CoA: 21.5
3-Methylbutyryl-CoA: 14.7

ptmS

AMP-binding (12..416): X

nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GLLVLAVPIK
Nearest Stachelhaus code(s):: Val DALVLAVSIK (38% 8Å match); Leu DALVLAVSIK (38% 8Å match)
Stachelhaus code match:: 70% (weak)