BGC0000120 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000120 (Penicillium expansum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	40,217	patulin	PKS:Iterative type I	100%

BGC0000120 - Region 1 - T1PKS

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Location: 1 - 40,217 nt. (total: 40,217 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 40,218
Label		BGC0000120

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000120	0.75	Polyketide	patulin	Penicillium expansum
BGC0001275	0.36	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273	0.36	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001244	0.35	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0002229	0.34	Polyketide	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872
BGC0001954	0.29	NRP, Polyketide	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0001264	0.27	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0000996	0.24	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0001276	0.23	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0000888	0.21	Other	bacilysin	Bacillus sp. CS93

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000120	1.00	Polyketide	patulin	Penicillium expansum
BGC0001275	0.69	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273	0.69	Polyketide	asperlactone	Aspergillus ochraceus
BGC0002670	0.68	Other	fosfonochlorin	Fusarium oxysporum f. sp. lycopersici 4287
BGC0001244	0.68	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0002229	0.66	Polyketide	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872
BGC0001954	0.64	NRP, Polyketide	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0000996	0.62	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0000676	0.60	Terpene	aphidicolin, aphidicolan-16β-ol, 3-deoxyaphidicolin, 17-deoxyaphidicolin	Phoma betae
BGC0002207	0.59	Other	psilocybin	Psilocybe cyanescens

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 14612 - 40217:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

patK

PKS_AT (568..859): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 70.8%; Ethylmalonyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 112.4
Methoxymalonyl-CoA: 91.8
Ethylmalonyl-CoA: 86.8
Isobutyryl-CoA: 77.0
Malonyl-CoA: 67.1
Propionyl-CoA: 47.3
Acetyl-CoA: 42.0
2-Methylbutyryl-CoA: 38.4
trans-1,2-CPDA: 33.9
3-Methylbutyryl-CoA: 29.8
fatty_acid: 25.8
Benzoyl-CoA: 22.8
CHC-CoA: 11.2
inactive: 8.3