BGC0000120 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000120 (Penicillium expansum)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	40,217	High	patulin	PKS:Iterative type I

BGC0000120 - Region 1 - T1PKS

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Location: 1 - 40,217 nt. (total: 40,217 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 40,218
Label		BGC0000120

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxygenase

patD: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

patH: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

patI: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

patN: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

patO: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

Ligases: synthase

patK: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000120.5	0.91	PKS	patulin	Penicillium expansum
BGC0001275.3	0.80	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.80	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.80	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.71	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002229.2	0.67	PKS	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000120.5	1.00	PKS	patulin	Penicillium expansum
BGC0001275.3	0.80	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.80	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.80	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.71	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002229.2	0.66	PKS	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 14612 - 40217:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

patK: pk

PKS_AT (568..859): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 70.8%; Ethylmalonyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 112.4
Methoxymalonyl-CoA: 91.8
Ethylmalonyl-CoA: 86.8
Isobutyryl-CoA: 77.0
Malonyl-CoA: 67.1
Propionyl-CoA: 47.3
Acetyl-CoA: 42.0
2-Methylbutyryl-CoA: 38.4
trans-1,2-CPDA: 33.9
3-Methylbutyryl-CoA: 29.8
fatty_acid: 25.8
Benzoyl-CoA: 22.8
CHC-CoA: 11.2
inactive: 8.3

Link to PARAS substrate predictor