BGC0000121 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000121 (Pestalotiopsis fici)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	40,346	High	Pestheic Acid/RES-1214-2	PKS:Type I

BGC0000121 - Region 1 - T1PKS

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Location: 1 - 40,346 nt. (total: 40,346 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 40,347
Label		BGC0000121

Tailoring functions

Oxidoreductases: oxidoreductase

ptaL: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: halogenase methyltransferase

ptaM: conventional flavin-dependent halogenase

halogenases: conventional flavin-dependent halogenase
smcogs: SMCOG1119: halogenase

ptaR1: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Hydrolases: hydrolase

ptaB: Decarboxylation

MITE: MITE0000163Decarboxylation (identity: 71.60%)
smcogs: SMCOG1170: metallo-beta-lactamase family protein

Lyases: hydrolase

ptaB: Decarboxylation

MITE: MITE0000163Decarboxylation (identity: 71.60%)
smcogs: SMCOG1170: metallo-beta-lactamase family protein

Ligases: synthase

ptaA: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000121.3	0.90	PKS	Pestheic Acid, RES-1214-2	Pestalotiopsis fici
BGC0001284.4	0.79	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001258.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002154.2	0.76	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002175.3	0.76	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.76	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0000156.5	0.63	PKS	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000121.3	1.00	PKS	Pestheic Acid, RES-1214-2	Pestalotiopsis fici
BGC0002608.2	0.79	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0001284.4	0.79	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001258.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002341.2	0.76	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002154.2	0.76	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002175.3	0.76	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.76	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0000156.5	0.63	PKS	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 29717:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ptaA: mal

PKS_AT (899..1197): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 62.5%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 91.6
inactive: 63.9
Methoxymalonyl-CoA: 52.0
Methylmalonyl-CoA: 50.5
Propionyl-CoA: 39.3
2-Methylbutyryl-CoA: 21.1
Ethylmalonyl-CoA: 18.9
Benzoyl-CoA: 18.4
Isobutyryl-CoA: 17.8
CHC-CoA: 17.2
trans-1,2-CPDA: 13.5
Acetyl-CoA: 10.9
fatty_acid: 10.2
3-Methylbutyryl-CoA: 8.0

Link to PARAS substrate predictor