BGC0000129 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000129 (Aspergillus fumigatus Af293)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	23,079	pyripyropene A	PKS	100%

BGC0000129 - Region 1 - T1PKS

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Location: 1 - 23,079 nt. (total: 23,079 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 23,080
Label		BGC0000129

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000129	1.00	Polyketide	pyripyropene A	Aspergillus fumigatus Af293
BGC0000687	0.33	Terpene	phyllocladan-16α-ol	Diaporthe amygdali
BGC0002736	0.31	Terpene	preaspterpenacid I	Aspergillus terreus NIH2624
BGC0002615	0.27	Terpene	4-oxomacrophorin A, macrophorin A, 5'-epimacrophorin B	Penicillium terrestre
BGC0001068	0.27	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000996	0.27	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0001244	0.26	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001775	0.26	Terpene	sespendole	Cordana terrestris
BGC0001264	0.26	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001954	0.25	NRP, Polyketide	wortmanamide A, wortmanamide B	Talaromyces wortmannii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000129	1.00	Polyketide	pyripyropene A	Aspergillus fumigatus Af293
BGC0000687	0.66	Terpene	phyllocladan-16α-ol	Diaporthe amygdali
BGC0002736	0.64	Terpene	preaspterpenacid I	Aspergillus terreus NIH2624
BGC0002615	0.61	Terpene	4-oxomacrophorin A, macrophorin A, 5'-epimacrophorin B	Penicillium terrestre
BGC0001068	0.61	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000996	0.61	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0001244	0.60	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001775	0.60	Terpene	sespendole	Cordana terrestris
BGC0001264	0.59	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001954	0.58	NRP, Polyketide	wortmanamide A, wortmanamide B	Talaromyces wortmannii

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 23079:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AFUA_6G13920

AMP-binding (32..448): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GDTYGSLVVK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

AFUA_6G13930

PKS_AT (547..858): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; Methylmalonyl-CoA: 58.3%; Ethylmalonyl-CoA: 54.2%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 56.0
Ethylmalonyl-CoA: 53.2
Propionyl-CoA: 33.7
Isobutyryl-CoA: 25.5
2-Methylbutyryl-CoA: 24.9
trans-1,2-CPDA: 22.3
Benzoyl-CoA: 18.5
fatty_acid: 12.3
CHC-CoA: 11.4
3-Methylbutyryl-CoA: 9.5
Acetyl-CoA: 2.1
Malonyl-CoA: -0.2
inactive: -1.3
Methylmalonyl-CoA: -2.3