BGC0000129 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000129 (Aspergillus fumigatus Af293)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	23,079	pyripyropene A	Terpene + Polyketide	37%

BGC0000129 - Region 1 - T1PKS

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Location: 1 - 23,079 nt. (total: 23,079 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 23,080
Label		BGC0000129

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000129.1	0.67	Polyketide	pyripyropene A	Aspergillus fumigatus Af293
BGC0001068.1	0.27	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001280.1	0.26	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.26	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001811.1	0.25	Terpene	trichodiene-11-one	Fusarium asiaticum
BGC0000930.1	0.25	Other	deoxynivalenol	Fusarium graminearum
BGC0000688.1	0.24	Terpene	copalyl diphosphate	Diaporthe amygdali
BGC0001909.1	0.24	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000056.1	0.23	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0000003.1	0.23	Polyketide	AF-toxin	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000129.1	0.87	Polyketide	pyripyropene A	Aspergillus fumigatus Af293
BGC0001068.1	0.61	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001280.1	0.59	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.59	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001811.1	0.58	Terpene	trichodiene-11-one	Fusarium asiaticum
BGC0000930.1	0.58	Other	deoxynivalenol	Fusarium graminearum
BGC0000688.1	0.58	Terpene	copalyl diphosphate	Diaporthe amygdali
BGC0001909.1	0.57	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000056.1	0.56	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0000003.1	0.56	Polyketide	AF-toxin	Alternaria alternata

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 23079:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

AFUA_6G13920

Search NORINE for peptide: strict or relaxed

AMP-binding (32..448): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: sfwygslvvk
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)

AFUA_6G13930

PKS_AT (547..858): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; Methylmalonyl-CoA: 58.3%; Ethylmalonyl-CoA: 54.2%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 56.0
Ethylmalonyl-CoA: 53.2
Propionyl-CoA: 33.7
Isobutyryl-CoA: 25.5
2-Methylbutyryl-CoA: 24.9
trans-1,2-CPDA: 22.3
Benzoyl-CoA: 18.5
fatty_acid: 12.3
CHC-CoA: 11.4
3-Methylbutyryl-CoA: 9.5
Acetyl-CoA: 2.1
Malonyl-CoA: -0.2
inactive: -1.3
Methylmalonyl-CoA: -2.3