BGC0000130: pyrrolomycin A biosynthetic gene cluster from Streptomyces vitaminophilus
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Location: 1 - 55,655 nt. (total: 55,655 nt).
This entry is originally from NCBI GenBank EF140901.1.

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core biosynthetic genes
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NRPS/PKS domains
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General information about the BGC
MIBiG accession BGC0000130
Short description pyrrolomycin A biosynthetic gene cluster from Streptomyces vitaminophilus
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: EF140901.1
Compounds
  • pyrrolomycin A
  • pyrrolomycin B
  • pyrrolomycin C
  • pyrrolomycin D
Species Streptomyces vitaminophilus [taxonomy]
References
Chemical products information
pyrrolomycin A
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C4H2Cl2N2O2
pyrrolomycin B
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C11H6Cl4N2O3
Chemical database entries
PubCHEM
pyrrolomycin C
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C11H5Cl4N1O2
Chemical database entries
NPAtlas
pyrrolomycin D
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C11H4Cl5N1O2
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABO15837.1
 1 - 843 (+) formate dehydrogenase
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  • ABO15838.1
  • pyr2
 892 - 2502 (-) FAD-dependent monooxygenase
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  • ABO15839.1
  • pyr3
 2579 - 3199 (-) TetR family regulator
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  • ABO15840.1
  • pyr4
 3490 - 5427 (+) 2-oxoglutarate ferredoxin oxidoreductase alpha subunit
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  • ABO15841.1
  • pyr5
 5513 - 6580 (+) 2-oxoglutarate ferredoxin oxidoreductase beta subunit
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  • ABO15842.1
  • pyr6
 6626 - 8065 (+) membrane antiporter
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  • ABO15843.1
  • pyr7
 8174 - 9313 (+) acyl-CoA dehydrogenase
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  • ABO15844.1
  • pyr8
 9376 - 10788 (+) amino acid adenyltransferase
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  • ABO15845.1
  • pyr9
 10788 - 11351 (+) flavin reductase
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  • ABO15846.1
  • pyr10
 11426 - 11725 (-) acyl-carrier protein
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  • ABO15847.1
  • pyr11
 11887 - 13560 (-) halogenase
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  • ABO15848.1
  • pyr12
 13733 - 14602 (-) hypothetical membrane protein
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  • ABO15849.1
  • pyr13
 14861 - 15643 (-) oxidoreductase
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  • ABO15850.1
  • pyr14
 16121 - 16639 (-) hypothetical protein
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  • ABO15851.1
  • pyr15
 17291 - 18232 (+) oxidoreductase
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  • ABO15852.1
  • pyr16
 18641 - 20395 (+) halogenase
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  • ABO15853.1
  • pyr17
 20429 - 22087 (+) halogenase
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  • ABO15854.1
  • pyr18
 22254 - 24338 (+) assimilatory nitrate reductase catalytic subunit
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  • ABO15855.1
  • pyr19
 24575 - 25996 (+) assimilatory nitrate reductase electron transfer subunit
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  • ABO15856.1
  • pyr20
 26400 - 27617 (+) cytochrome P450
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  • ABO15857.1
  • pyr21
 27983 - 28297 (+) monooxygenase
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  • ABO15858.1
  • pyr22
 28625 - 29323 (-) methyl transferase
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  • ABO15859.1
  • pyr23
 29608 - 30675 (-) putative membrane protein
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  • ABO15860.1
  • pyr24
 30893 - 37588 (-) polyketide synthase
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  • ABO15861.1
  • pyr25
 37591 - 44094 (-) polyketide synthase
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  • ABO15862.1
  • pyr26
 44146 - 45054 (+) thioesterase
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  • ABO15863.1
  • pyr27
 45020 - 45643 (-) TetR family regulator
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  • ABO15864.1
  • pyr28
 45992 - 46264 (+) proline carrier protein
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  • ABO15865.1
  • pyr29
 46328 - 47671 (+) halogenase
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  • ABO15866.1
  • pyr30
 47945 - 48838 (-) 4'-phosphopantetheinyl transferase
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  • ABO15867.1
  • pyr31
 49044 - 50828 (-) acyl-CoA dehydrogenase
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  • ABO15868.1
 51057 - 52499 (+) homogentisate 1,2-dioxygenase
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  • ABO15869.1
 52496 - 53248 (+) GntR-family regulator
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  • ABO15870.1
 53341 - 54492 (+) acyl-CoA dehydrogenase
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  • ABO15871.1
 54492 - 55655 (+) L-carnitine dehydratase
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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