LOCUS       BGC0000131              6280 bp    DNA     linear   BCT 07-MAR-2007
DEFINITION  Streptomyces sp. UC 11065 pyrrolomycin biosynthetic gene cluster,
            partial sequence.
ACCESSION   BGC0000131
VERSION     BGC0000131
KEYWORDS    .
SOURCE      Streptomyces sp. UC 11065
  ORGANISM  Streptomyces sp. UC 11065
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 12:56:50
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            1..1125
                     /gene="dox5"
     CDS             1..1125
                     /codon_start=1
                     /gene="dox5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_kind="biosynthetic-additional"
                     /product="2-oxoglutarate ferredoxin oxidoreductase beta
                     subunit"
                     /protein_id="ABO15872.1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.5e-33, bitscore:
                     103.7, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEALVTADGADGADGHRPGGARALALVPTSDVKQTARTFKSDQE
                     VRWCPGCGDYAILAAVQGFLPELGLARENIVFISGIGCSSRFPYYMNTYGMHSIHGRAP
                     AIATGLSTSRQDLSVWVVTGDGDALSIGGNHLIHALRRNVNLKILLFNNRIYGLTKGQY
                     SPTSETGKITKSTPMGSLDTPFNPVSLALGAEATFVARTIDSDRKHLTNVLRQAAHHPG
                     TALVEIYQNCNIFNDGAFDTLKDNNTAAQALIPLEHGQPIRFGTPAADGLGTHGVIRDP
                     HTGDLRIIDVTTHGTDGILTHDAHATTPTTAFALSRLADPDTLHHTPIGVFRDIERPVY
                     DASMAAQLDRAIEQKGKGDLAVLLAGDDTWTVKN"
     source          1..6280
                     /db_xref="taxon:428401"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sp. UC 11065"
                     /strain="UC 11065"
     misc_feature    <1..>6280
                     /note="pyrrolomycin biosynthetic gene cluster"
     subregion       1..6280
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000131"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..6280
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1163..2602
                     /gene="dox6"
     CDS             1163..2602
                     /codon_start=1
                     /gene="dox6"
                     /gene_functions="transport (smcogs)
                     SMCOG1117:sodium/hydrogen exchanger (Score: 373.6; E-value:
                     1.8e-113)"
                     /gene_kind="transport"
                     /product="membrane antiporter"
                     /protein_id="ABO15873.1"
                     /transl_table=11
                     /translation="MTDTHKHAEWIVTVAIGDVALVLAVGTLFVLLARRVKQPAVIGEI
                     TAGICLGPSLLGLFPGDLPQRLFPTDVRPYLNVVAQIGLLLFMFIIGWEFDYASMKGRR
                     RDVGTIWISAAALPVAMGMGLAVLLHGSNDVVNGKSVRMVDFALYLGIAMSIAAFPVLA
                     RIITDHRLQLTRVGTLALALAALDDILAWSMLAIVVALVTATGTGGFLGVLGWGAVYIL
                     VMLVIGRPLLAAVAAAHQRGHAYPKPCHASGTLCSAYVTSEIGLHAIFGAFVFGLVMPR
                     GPQQEMFHNAAMVPLEHISKLLLPLFFVVSGLSVDLTAMTADGLIQMCVIICVAITGQL
                     GGVLLPARVTAMSRHDSTILGLLMNTRGLTELVILHVGRSLALLSVELFTAMVMMALVT
                     TGMTSPFLTMMLRRTKPHSEARCHRRPRPGSRTAERAESLLPPGTPTDRPARPAARPHL
                     AAPRGRDAAPRGPRPRFGDTE"
     gene            2698..3837
                     /gene="dox7"
     CDS             2698..3837
                     /codon_start=1
                     /gene="dox7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006:acyl-CoA dehydrogenase (Score: 368.8; E-value:
                     5.4e-112)"
                     /gene_kind="biosynthetic-additional"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="ABO15874.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.4e-23, bitscore:
                     72.5, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 4.3e-27, bitscore:
                     83.0, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 6e-40, bitscore:
                     125.6, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFGWTKEQRARYDETLAAVREAFPADGPPSTDYYTREDWKRLGG
                     LGLLGLSIPRAYGGGGHGALDTALLVEALGRGCAETGLVFGASAHLFACAMPVVDYGTE
                     ELRKRILPGICSGELIAGNAMTEADAGSDVSKLSVTATRADGGWVLNGEKSFVSNGPAA
                     DVYTTYATTDPKAGPFGVTGFIVERSAPGVTASEPFDKMGLLQCPAGSVRFEDTFVPDE
                     NVLGEPGQGGWIFQHSMGWERACLFAGYVGLADRVLESCVAHVKGRRQFGKRLSEFQAV
                     SHRIADMKLRLESARLLLYRACWEMDEGLPATLSIALSKLAVSEGVVASALDAVRLFGG
                     RGYQRADRIEAALRDAVPSVIFSGTSDIQRQLIARELGL"
     gene            3843..5312
                     /gene="dox8"
     CDS             3843..5312
                     /NRPS_PKS="Domain: AMP-binding (8-392). E-value: 1.1e-90.
                     Score: 296.0. Matches aSDomain:
                     nrpspksdomains_dox8_AMP-binding.1"
                     /codon_start=1
                     /gene="dox8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     338.4; E-value: 9.9e-103)"
                     /gene_kind="biosynthetic-additional"
                     /product="amino acid adenyltransferase"
                     /protein_id="ABO15875.1"
                     /sec_met_domain="AMP-binding (E-value: 4.8e-99, bitscore:
                     320.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLHDLLIESARRDPDAVAVHGPQGPTSYWELDRLADRYAAALTG
                     RGVARGDRVVVWSQKSTEAIALMQAALRVGAIYIPVTGSNPPARLTRIAANAGPALVVA
                     DEDAAFRARKAKWDRRPLLSLDDVRRKASDGARPKPYENEPDEPAYILYTSGSTGDPKG
                     VCISHRNALAFVEWAAAEVEVGPSDRLSNHAPFNFDLSCFDLYAAFLAGASVHLVPQEI
                     AYAPEQLVRFMRDRGITVWYSVPSALSLMIREGGLLDGPPPPDLRACLFAGEPFAIHHV
                     HALRKGWPGVRLLNWYGPTETNVCTSYEVTDADLERDRPVPIGKACSGDTVILDPDDGG
                     EGEVVVSGPTVMLGYWGREPQRGPYRTGDIARLDPRGDLEYAGRRDHMVKVRGHRIELG
                     EIEAAIASLDTVSDVAVLVVGSGLEAQLHAVAVASETHRPSLLTVKRACAERLPTYMII
                     DKLHLIEDLPRTANGKTDRARLTAAIEAGDL"
     aSDomain        3867..5018
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_dox8_AMP-binding.1"
                     /evalue="1.10E-90"
                     /label="dox8_AMP-binding.1"
                     /locus_tag="dox8"
                     /protein_end="392"
                     /protein_start="8"
                     /score="296.0"
                     /specificity="substrate consensus: Pro"
                     /tool="antismash"
                     /translation="ESARRDPDAVAVHGPQGPTSYWELDRLADRYAAALTGRGVARGDR
                     VVVWSQKSTEAIALMQAALRVGAIYIPVTGSNPPARLTRIAANAGPALVVADEDAAFRA
                     RKAKWDRRPLLSLDDVRRKASDGARPKPYENEPDEPAYILYTSGSTGDPKGVCISHRNA
                     LAFVEWAAAEVEVGPSDRLSNHAPFNFDLSCFDLYAAFLAGASVHLVPQEIAYAPEQLV
                     RFMRDRGITVWYSVPSALSLMIREGGLLDGPPPPDLRACLFAGEPFAIHHVHALRKGWP
                     GVRLLNWYGPTETNVCTSYEVTDADLERDRPVPIGKACSGDTVILDPDDGGEGEVVVSG
                     PTVMLGYWGREPQRGPYRTGDIARLDPRGDLEYAGRRDHMVKVR"
     CDS_motif       4287..4346
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_dox8_0001"
                     /evalue="2.40E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="dox8"
                     /protein_end="168"
                     /protein_start="148"
                     /score="32.2"
                     /tool="antismash"
                     /translation="AYILYTSGSTGDPKGVCISH"
     CDS_motif       4857..4919
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_dox8_0002"
                     /evalue="5.30E-06"
                     /label="NRPS-A_a6"
                     /locus_tag="dox8"
                     /protein_end="359"
                     /protein_start="338"
                     /score="18.8"
                     /tool="antismash"
                     /translation="GGEGEVVVSGPTVMLGYWGRE"
     CDS_motif       4983..5048
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_dox8_0003"
                     /evalue="1.50E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="dox8"
                     /protein_end="402"
                     /protein_start="380"
                     /score="36.2"
                     /tool="antismash"
                     /translation="YAGRRDHMVKVRGHRIELGEIE"
     gene            5312..5875
                     /gene="dox9"
     CDS             5312..5875
                     /codon_start=1
                     /gene="dox9"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160:flavin reductase domain protein FMN-binding
                     (Score: 130.1; E-value: 9.7e-40)"
                     /gene_kind="biosynthetic-additional"
                     /product="flavin reductase"
                     /protein_id="ABO15876.1"
                     /transl_table=11
                     /translation="MTLQAQTLSAFLPQTPAEPLPSVDLQTFRFVMGSFASGVSVVRAG
                     TKQDRPRGLTCSAICSVSIDPPLLLSSVSNRSGTLAAILATGKFAVNILGAQGQAVSQL
                     FASGAEDKFERVRWEPGTLTGSPLFQVTVAHAECELYNAVEAGDHTLLIGRVVSGGTEQ
                     DRLPLAYWRGSYQRVSQESTPRVT"
     gene            complement(5984..6280)
                     /gene="dox10"
     CDS             complement(5984..6280)
                     /NRPS_PKS="Domain: ACP (12-82). E-value: 1.3e-15. Score:
                     49.3. Matches aSDomain: nrpspksdomains_dox10_ACP.1"
                     /codon_start=1
                     /gene="dox10"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1047:phosphopantetheine-binding domain-containing
                     protein (Score: 57.2; E-value: 2.4e-17)"
                     /gene_kind="biosynthetic-additional"
                     /product="acyl-carrier protein"
                     /protein_id="ABO15877.1"
                     /sec_met_domain="PP-binding (E-value: 2.7e-14, bitscore:
                     42.3, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIELSITRRVIQDWLVERFAAHLGVPEEQIAADAYIDELPLDSVD
                     AVAVVVELERWFGRQLDVWEVRRHPTIGELADFLAREYARRPAVPNARPAPAA"
     CDS_motif       complement(6023..6061)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_dox10_0001"
                     /evalue="1.20E-01"
                     /label="PKSI-KR_m1"
                     /locus_tag="dox10"
                     /protein_end="86"
                     /protein_start="73"
                     /score="5.1"
                     /tool="antismash"
                     /translation="ELADFLAREYARR"
     aSDomain        complement(6035..6244)
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_dox10_ACP.1"
                     /evalue="1.30E-15"
                     /label="dox10_ACP.1"
                     /locus_tag="dox10"
                     /protein_end="82"
                     /protein_start="12"
                     /score="49.3"
                     /tool="antismash"
                     /translation="DWLVERFAAHLGVPEEQIAADAYIDELPLDSVDAVAVVVELERWF
                     GRQLDVWEVRRHPTIGELADFLARE"
ORIGIN
        1 atgtctgagg cacttgtgac ggccgacggg gcagacgggg ccgacgggca ccgccccggc
       61 ggggcccgcg ctctggcgct ggtcccgacc agcgatgtca agcagaccgc gcgcaccttc
      121 aagtccgacc aggaagtgcg ctggtgcccc ggctgcggcg actacgccat cctcgccgcc
      181 gtccagggct tcctgcccga actcggcctc gcccgcgaga acatcgtctt catctccggc
      241 atcggctgct cctcccgctt cccctactac atgaacacct acgggatgca ctccatccac
      301 ggacgcgcac ccgccatcgc caccggcctc tcaaccagcc ggcaagacct gtccgtctgg
      361 gtcgtcaccg gcgacggcga cgccctgtcc atcggcggca accacctcat ccacgccctc
      421 cgccgcaacg tcaacctcaa aatcctcctg ttcaacaacc gcatctacgg cctcaccaaa
      481 ggccagtact cccccacctc ggagaccggg aaaatcacca aatccacccc catgggatcc
      541 ctggacaccc ccttcaaccc cgtctccctc gccctcggag ccgaagccac cttcgtcgcc
      601 cgcaccatcg actccgaccg caaacacctc accaacgtcc tgcgccaagc cgcccaccac
      661 cccggcaccg ccctcgtcga gatctaccag aactgcaaca tcttcaacga cggcgccttc
      721 gacaccctca aagacaacaa caccgccgcc caggccctga tccccctgga gcacggccag
      781 cccatccgct tcggcacccc cgccgccgac ggcctgggca cgcacggtgt gatccgcgac
      841 ccccacaccg gcgacctgcg catcatcgac gtcaccaccc acggcaccga cggcatcctc
      901 acccacgacg cccacgccac cacccccacc accgccttcg ccctctcccg cctcgccgac
      961 cccgacaccc tccaccacac ccccatcggc gtcttccggg acatcgagcg gcctgtctac
     1021 gacgcctcca tggcggccca gctcgaccgc gccatcgaac agaaggggaa aggcgatctc
     1081 gccgtcctcc tcgcaggcga tgacacctgg acggtcaaga actgatcgcc gggaaccgcc
     1141 cgatcacatc cggggagttg gagtgaccga cacacacaag cacgcggaat ggatcgtcac
     1201 cgtcgcgatc ggcgacgtgg cgctggtact cgcggtagga acgctcttcg tcctcctcgc
     1261 gcgccgcgtg aagcagccgg cggtcatcgg cgagatcacc gcgggcatct gcctcgggcc
     1321 gagcctgctg ggcctttttc caggtgacct tccacaacgt cttttcccaa ccgatgtcag
     1381 gccgtatctg aatgtcgtcg cccagatcgg cctgctgctt ttcatgttca tcatcggatg
     1441 ggaattcgac tacgcgtcca tgaaggggcg gcgccgcgac gtcggcacca tctggatctc
     1501 cgcggcggcg ctgccggtcg ccatgggcat gggcctcgcg gtcctgctgc acggctccaa
     1561 cgacgtggtc aacggcaagt cggtgcgcat ggtggacttc gcgctctacc tgggcatcgc
     1621 catgtccatc gcggcgttcc cggtgctcgc gcgcatcatc accgaccacc ggctgcaact
     1681 cacccgcgtg ggaacgctgg cgctggcgct ggccgcgctg gacgacatcc tcgcctggtc
     1741 gatgctcgcg atcgtggtgg ccctggtgac ggccaccggc accgggggct tcctcggcgt
     1801 gctgggctgg ggcgccgtct acatcctggt gatgctggtg atcggccgcc ccctcctggc
     1861 cgcggtggcc gccgctcacc agcgcgggca cgcgtaccct aaaccgtgcc acgcctccgg
     1921 gacgctctgc tcggcctatg tcacctcgga gatcggcctg cacgccatct tcggcgcgtt
     1981 cgtcttcggc ctggtgatgc cgcgcgggcc gcagcaggag atgttccaca acgcggcgat
     2041 ggtcccgctg gagcacatca gcaagctgct gctgccgctg ttcttcgtcg tctccggcct
     2101 ttcggtggac ctcaccgcca tgacggccga cggcctgatc cagatgtgcg tgatcatctg
     2161 cgtggccatc acgggccagc tcggcggggt gctgctgccg gcccgggtga ccgccatgag
     2221 caggcacgac tccacaatcc tcggcttgct gatgaacacc cgggggctca ccgaactggt
     2281 gatcctccac gtcggtcgca gcctggccct gctcagcgtc gaactgttca ccgcgatggt
     2341 gatgatggcc ctggtcacga ccggtatgac ctcccccttc ctgaccatga tgctgcggcg
     2401 caccaagccc cactccgagg cgcggtgcca ccgcaggccg cggccgggga gcaggacggc
     2461 ggagcgcgcc gagtccctgc tgcccccggg aacgccgact gaccgacccg cgcgcccggc
     2521 ggcgcggccg cacctggccg ccccgcgcgg gcgggacgcg gcgccccggg gcccgcgacc
     2581 acgattcggt gacacagagt aattacttgc agacgtaacg cacccgaccc gaaggaaagc
     2641 gaccggtcca ggccgtccgc cggatccgga ccgcccgatt caccagcgga ggaacccgtg
     2701 gagttcggct ggacgaaaga gcaacgggcc cgctacgacg agaccctcgc cgccgtgcgc
     2761 gaggcgttcc ccgccgacgg gcccccttcg accgactact acacccgtga ggactggaag
     2821 cgcctgggcg gactcgggct gctgggtctg tccattccgc gcgcgtacgg cggcggcggg
     2881 cacggggccc tggacaccgc gctgctcgtg gaggccctgg gccgcggctg cgccgagacc
     2941 ggcctggtct tcggggccag cgcccacctg ttcgcgtgcg ccatgcccgt cgtggactac
     3001 ggcacggagg agctgcgcaa gcggatcctg ccgggcatct gcagcggcga gctgatcgcg
     3061 ggcaacgcca tgacggaggc cgacgccggc tccgacgtgt ccaagctgtc cgtcaccgcg
     3121 acccgcgccg acgggggctg ggtgctcaac ggcgagaaga gcttcgtcag caacggcccc
     3181 gccgccgacg tctacaccac ctacgccacc accgacccca aggccggccc cttcggcgtc
     3241 accggcttca tcgtggagcg ctccgcgccg ggcgtcaccg cgagcgagcc gttcgacaag
     3301 atgggcctgc tccagtgccc ggccggcagc gtccgcttcg aggacacctt cgtgccggac
     3361 gagaacgtcc tcggcgagcc cggccagggc ggctggatct tccagcactc catgggctgg
     3421 gagcgggcct gcctgttcgc cggctacgtc ggcctcgccg accgggtgct ggagagctgc
     3481 gtcgcccatg tgaagggccg ccgccagttc gggaagcggc tgtcggagtt ccaggccgtc
     3541 tcgcaccgga tcgcggacat gaagctgcgc ctggagagcg cccggctcct gctgtaccgc
     3601 gcctgctggg agatggacga gggcctgccg gccaccctgt ccatcgccct ttccaagctg
     3661 gccgtgtccg agggcgtcgt ggccagcgcc ctcgacgcgg tgcgcctgtt cggcggccgc
     3721 gggtaccagc gcgccgaccg catcgaggcg gcgctgcgtg acgcggtgcc gtcggtgatc
     3781 ttctccggca cctccgacat ccagcggcaa ctcatcgcaa gggagctcgg cctatgaggt
     3841 ccatgaggct gcacgacctg ctcatcgagt cggcccggcg cgatcccgac gccgtcgccg
     3901 tccacgggcc gcagggcccg acgtcctact gggagctcga ccgcctcgcc gaccgctacg
     3961 ccgccgccct gaccggccgc ggggtcgcgc gcggcgaccg ggtggtggtc tggagccaga
     4021 agagcaccga ggccatcgcc ctgatgcagg cggcgctgcg cgtcggcgcc atctacatcc
     4081 ccgtcaccgg ctccaacccg cccgcgcggc tgacgaggat cgcggcgaac gcagggcccg
     4141 cgctcgtcgt ggccgacgag gacgcggcgt tccgcgcccg caaggcgaag tgggaccggc
     4201 ggccgctgct cagcctggac gacgtgcgcc gcaaggcgtc cgacggcgcc cggcccaagc
     4261 cctacgagaa cgagccggac gaacccgcct acatcctgta cacctccggc tccaccggcg
     4321 acccgaaggg cgtgtgcatc agccaccgca acgccctggc cttcgtggag tgggcggcgg
     4381 ccgaggtgga ggtgggcccg tcggaccggc tgtccaacca cgccccgttc aacttcgacc
     4441 tgtcctgctt cgacctgtac gccgcgttcc tggccggcgc ctcggtgcac ctggtgccgc
     4501 aggagatcgc gtacgccccg gagcagctgg tccggttcat gcgggaccgc gggatcacgg
     4561 tctggtactc ggtgccgtcc gcgctgagcc tgatgatccg cgagggcggg ctgctggacg
     4621 ggccgccccc gccggacctg cgggcctgcc tgttcgcggg cgagccgttc gccatccacc
     4681 atgtgcacgc cctgcgcaag ggctggcccg gggtgcgcct gctcaactgg tacggcccca
     4741 ccgagaccaa cgtctgcacc tcctacgagg tcaccgacgc ggacctggag cgcgaccggc
     4801 cggtgccgat cggcaaggcg tgctccgggg acaccgtgat cctcgacccg gacgacggcg
     4861 gcgagggcga ggtcgtggtg tccgggccga ccgtgatgct cggctactgg ggcagggagc
     4921 cgcagcgcgg cccgtaccgc acgggcgaca tcgcccgtct cgacccgcgc ggcgacctgg
     4981 agtacgcggg ccgccgcgac cacatggtga aggtccgcgg ccaccgcatc gaactcggcg
     5041 agatcgaggc ggccatcgcc tcgctcgaca cggtctccga cgtggccgtc ctcgtcgtgg
     5101 gctcggggct cgaggcccag ttgcacgccg tcgccgtcgc ctcggagaca caccgtccgt
     5161 cgttgctcac cgtcaagcgc gcctgcgcgg aaaggctgcc gacctacatg atcatcgaca
     5221 agctgcacct gatcgaggac ctgcccagga ccgccaatgg caagaccgac cgggcgcggc
     5281 tcaccgcggc catagaagcg ggtgacctct gatgacactc caggcccaga ccctctccgc
     5341 cttcctcccc cagaccccgg cggagccgct gccgtccgtg gacctgcaga cgttccgctt
     5401 cgtgatgggc tccttcgcca gcggggtctc cgtggtccgc gcggggacca agcaggaccg
     5461 cccgcgcggg ctgacctgct ccgccatctg cagcgtctcc atcgaccccc cgctgctgct
     5521 gtccagcgtc agcaaccgca gcgggacgct ggcggcgatc ctggccaccg gcaagttcgc
     5581 cgtgaacatc ctcggcgcgc aggggcaggc ggtgtcccag ctgttcgcct ccggcgccga
     5641 ggacaagttc gagcgggtcc gctgggagcc gggcacgctg accggcagcc ccctgttcca
     5701 ggtgacggtg gcgcacgcgg agtgcgagct gtacaacgcg gtggaggccg gcgaccacac
     5761 cctgctgatc ggccgggtgg tcagcggcgg caccgagcag gaccgcctgc cgctggcgta
     5821 ctggcgcggt tcctaccagc gcgtctccca ggagagcacc cccagggtca cctgagcgac
     5881 cgcaccgccc gcgggcggga gcgcggcagc gccgccggta ccccaggggt gccggcggcg
     5941 cgcacgtgcg ggccgagccg ttcggacggg actcgggagc cggtcaggcg gcgggcgcgg
     6001 ggcgcgcgtt cggcacggcc gggcggcggg cgtactcccg cgccaggaag tccgccagct
     6061 ccccgatcgt ggggtggcgg cgcacctccc acacgtcgag ctgccggccg aaccaccgct
     6121 ccagctccac gacgacggcg accgcgtcga cggagtcgag ggggagctcg tcgatgtacg
     6181 cgtcggccgc gatctgctcc tcgggcacgc cgaggtgcgc ggcgaaccgc tcgacgagcc
     6241 agtcctgtat caccctgcga gtgatggaga gttcgatcat
//
