BGC0000132 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000132 (Streptomyces sp. UC 11065)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	19,907	pyrrolomycin	PKS	100%

BGC0000132 - Region 1 - T1PKS

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Location: 1 - 19,907 nt. (total: 19,907 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 19,908
Label		BGC0000132

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000132	1.00	Polyketide	pyrrolomycin	Streptomyces sp. UC 11065
BGC0002631	0.32	RiPP	myxarylin	Pyxidicoccus fallax
BGC0000924	0.30	Other	pyrrolnitrin	Pseudomonas chlororaphis
BGC0001605	0.25	Terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001201	0.23	Terpene	eremophilene	Sorangium cellulosum So ce56
BGC0001310	0.22	Polyketide	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0000264	0.22	Polyketide	resistomycin, resistoflavine	Streptomyces resistomycificus
BGC0002213	0.21	Polyketide	HEx-pks16 polyketide	Punctularia strigosozonata HHB-11173 SS5
BGC0001782	0.21	Other	spiroindimicin A, spiroindimicin B, spiroindimicin C, spiroindimicin D, indimicin A, indimicin B, indimicin C, indimicin D, indimicin E, lynamicin A, lynamicin D, lynamicin F, lynamicin G	Streptomyces sp. SCSIO 03032
BGC0001224	0.21	Other	reductasporine	uncultured bacterium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000132	1.00	Polyketide	pyrrolomycin	Streptomyces sp. UC 11065
BGC0002631	0.65	RiPP	myxarylin	Pyxidicoccus fallax
BGC0000924	0.63	Other	pyrrolnitrin	Pseudomonas chlororaphis
BGC0001605	0.58	Terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001201	0.57	Terpene	eremophilene	Sorangium cellulosum So ce56
BGC0001310	0.55	Polyketide	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0000264	0.55	Polyketide	resistomycin, resistoflavine	Streptomyces resistomycificus
BGC0002213	0.54	Polyketide	HEx-pks16 polyketide	Punctularia strigosozonata HHB-11173 SS5
BGC0001782	0.53	Other	spiroindimicin A, spiroindimicin B, spiroindimicin C, spiroindimicin D, indimicin A, indimicin B, indimicin C, indimicin D, indimicin E, lynamicin A, lynamicin D, lynamicin F, lynamicin G	Streptomyces sp. SCSIO 03032
BGC0001224	0.53	Other	reductasporine	uncultured bacterium

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 19907:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ccmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

dox24

PKS_AT (399..693): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 208.9
inactive: 119.4
Methylmalonyl-CoA: 85.7
Methoxymalonyl-CoA: 84.1
Propionyl-CoA: 56.7
Ethylmalonyl-CoA: 54.5
Isobutyryl-CoA: 43.7
2-Methylbutyryl-CoA: 28.0
trans-1,2-CPDA: 27.6
CHC-CoA: 25.9
Benzoyl-CoA: 25.5
Acetyl-CoA: 22.3
fatty_acid: 14.1
3-Methylbutyryl-CoA: 2.7