BGC0000132 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000132 (Streptomyces sp. UC 11065)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	19,907	pyrrolomycin A / pyrrolomycin B / pyrrolomycin C / pyrrolomycin D	Polyketide	22%

BGC0000132 - Region 1 - T1PKS

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Location: 1 - 19,907 nt. (total: 19,907 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 19,908
Label		BGC0000132

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000132.1	1.00	Polyketide	pyrrolomycin	Streptomyces sp. UC 11065
BGC0002031.1	0.31	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0000924.1	0.30	Other	pyrrolnitrin	Pseudomonas chlororaphis
BGC0001280.1	0.29	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.29	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001858.1	0.28	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001068.1	0.25	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000056.1	0.24	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0001201.1	0.23	Terpene	eremophilene	Sorangium cellulosum So ce56
BGC0001909.1	0.23	Polyketide	strobilurin	Strobilurus tenacellus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000132.1	1.00	Polyketide	pyrrolomycin	Streptomyces sp. UC 11065
BGC0002031.1	0.64	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0000924.1	0.63	Other	pyrrolnitrin	Pseudomonas chlororaphis
BGC0001280.1	0.63	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.63	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0001858.1	0.62	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001068.1	0.58	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000056.1	0.57	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0001201.1	0.56	Terpene	eremophilene	Sorangium cellulosum So ce56
BGC0001909.1	0.56	Polyketide	strobilurin	Strobilurus tenacellus

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 19907:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ccmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

dox24

PKS_AT (399..693): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 208.9
inactive: 119.4
Methylmalonyl-CoA: 85.7
Methoxymalonyl-CoA: 84.1
Propionyl-CoA: 56.7
Ethylmalonyl-CoA: 54.5
Isobutyryl-CoA: 43.7
2-Methylbutyryl-CoA: 28.0
trans-1,2-CPDA: 27.6
CHC-CoA: 25.9
Benzoyl-CoA: 25.5
Acetyl-CoA: 22.3
fatty_acid: 14.1
3-Methylbutyryl-CoA: 2.7