BGC0000133 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000133 (Amycolatopsis orientalis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	82,338	quartromicin A1	PKS	100%

BGC0000133 - Region 1 - T1PKS

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Location: 1 - 82,338 nt. (total: 82,338 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 82,339
Label		BGC0000133

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000133	0.89	Polyketide	quartromicin A1	Amycolatopsis orientalis
BGC0000016	0.40	Other	amphotericin B	Streptomyces nodosus
BGC0000041	0.33	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000067	0.30	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001244	0.30	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001275	0.29	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002597	0.28	NRP, Polyketide	nocuolactylates	Nodularia sp. LEGE 06071
BGC0001704	0.28	Other	nocuolin A	Nodularia sp. HBU26
BGC0000935	0.27	Other (Aminocoumarin), Polyketide	esmeraldin	Streptomyces antibioticus
BGC0002171	0.26	NRP, Polyketide	pyrophen, campyrone B	Aspergillus niger ATCC 1015

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000133	1.00	Polyketide	quartromicin A1	Amycolatopsis orientalis
BGC0000016	0.72	Other	amphotericin B	Streptomyces nodosus
BGC0000041	0.66	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002631	0.65	RiPP	myxarylin	Pyxidicoccus fallax
BGC0002084	0.65	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0002099	0.65	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0002000	0.64	Polyketide	setomimycin	Streptomyces aurantiacus JA 4570
BGC0002514	0.64	Polyketide	julichrome Q6.6	Streptomyces sampsonii
BGC0002012	0.64	Polyketide	julichrome Q3-3, julichrome Q3-5	Streptomyces afghaniensis 772
BGC0000067	0.64	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 3934 - 70896:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-ccmal - Me-ccmal - ccmal) + (Me-ccmal) + (mal)
Non-colinear ordering:: AFI57005.1 + AFI57006.1 + AFI57007.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AFI57005.1

PKS_AT (493..778): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 205.9
inactive: 116.8
Methoxymalonyl-CoA: 69.0
Methylmalonyl-CoA: 62.7
Propionyl-CoA: 44.9
Isobutyryl-CoA: 34.7
Ethylmalonyl-CoA: 22.8
Acetyl-CoA: 16.9
2-Methylbutyryl-CoA: 15.2
fatty_acid: 12.7
Benzoyl-CoA: 10.5
CHC-CoA: 10.1
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (1471..1758): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 217.4
Ethylmalonyl-CoA: 211.8
Methoxymalonyl-CoA: 175.7
trans-1,2-CPDA: 145.8
2-Methylbutyryl-CoA: 141.1
Propionyl-CoA: 114.1
Malonyl-CoA: 103.1
CHC-CoA: 85.7
Isobutyryl-CoA: 81.4
Benzoyl-CoA: 65.2
Acetyl-CoA: 48.3
fatty_acid: 42.4
3-Methylbutyryl-CoA: 36.5
inactive: 22.9

PKS_AT (3116..3408): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 218.4
Ethylmalonyl-CoA: 206.1
Methoxymalonyl-CoA: 166.7
2-Methylbutyryl-CoA: 149.3
trans-1,2-CPDA: 127.1
Propionyl-CoA: 106.6
Malonyl-CoA: 90.8
CHC-CoA: 90.0
Benzoyl-CoA: 73.8
Isobutyryl-CoA: 67.8
fatty_acid: 33.6
Acetyl-CoA: 32.4
3-Methylbutyryl-CoA: 29.7
inactive: 14.2

PKS_AT (4787..5068): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 217.4
inactive: 108.2
Methoxymalonyl-CoA: 65.7
Methylmalonyl-CoA: 55.2
Propionyl-CoA: 43.6
Benzoyl-CoA: 31.4
Ethylmalonyl-CoA: 29.6
Isobutyryl-CoA: 28.2
2-Methylbutyryl-CoA: 23.4
Acetyl-CoA: 22.6
fatty_acid: 17.4
trans-1,2-CPDA: 16.6
CHC-CoA: 15.1
3-Methylbutyryl-CoA: 0.0

AFI57006.1

PKS_AT (568..867): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 213.6
Ethylmalonyl-CoA: 209.4
Methoxymalonyl-CoA: 176.2
2-Methylbutyryl-CoA: 155.5
trans-1,2-CPDA: 132.8
Propionyl-CoA: 116.3
Malonyl-CoA: 112.9
CHC-CoA: 106.5
Isobutyryl-CoA: 76.9
Benzoyl-CoA: 56.5
Acetyl-CoA: 38.9
3-Methylbutyryl-CoA: 36.7
fatty_acid: 29.9
inactive: 16.4

AFI57007.1

PKS_AT (563..854): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.2
inactive: 105.5
Methoxymalonyl-CoA: 62.9
Methylmalonyl-CoA: 48.8
Isobutyryl-CoA: 35.1
Propionyl-CoA: 30.7
Acetyl-CoA: 14.9
Benzoyl-CoA: 11.9
fatty_acid: 10.6
CHC-CoA: 6.8
trans-1,2-CPDA: 6.3
Ethylmalonyl-CoA: 5.2
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0