BGC0000134 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000134 (Pochonia chlamydosporia (Metacordyceps chlamydosporia))

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	31,332	radicicol	PKS	100%

BGC0000134 - Region 1 - T1PKS

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Location: 1 - 31,332 nt. (total: 31,332 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 31,333
Label		BGC0000134

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000134	1.00	Polyketide	radicicol	Pochonia chlamydosporia
BGC0002187	0.74	Polyketide	monorden D, monocillin IV, monocillin VI, monocillin VII, pochonin M, monocillin V, monocillin II	Pochonia chlamydosporia 170
BGC0002608	0.38	NRP, Polyketide	ochratoxin A	Aspergillus steynii
BGC0000046	0.32	Polyketide	depudecin	Alternaria brassicicola
BGC0002301	0.32	Polyketide	(P)-ustilaginoidin A	Aschersonia paraphysata
BGC0001286	0.31	Other	itaconic acid	Ustilago maydis
BGC0001124	0.31	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0002180	0.30	Polyketide	(+)-asperlin, (2Z,4Z,6E)-octa-2,4,6-trienoic acid	Aspergillus nidulans FGSC A4
BGC0002227	0.29	NRP	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0002177	0.29	Polyketide	ustilaginoidin N, ustilaginoidin O, ustilaginoidin M, ustilaginoidin A, ustilaginoidin F, ustilaginoidin E, ustilaginoidin D, ustilaginoidin G	Ustilaginoidea virens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000134	1.00	Polyketide	radicicol	Pochonia chlamydosporia
BGC0002187	0.90	Polyketide	monorden D, monocillin IV, monocillin VI, monocillin VII, pochonin M, monocillin V, monocillin II	Pochonia chlamydosporia 170
BGC0002608	0.71	NRP, Polyketide	ochratoxin A	Aspergillus steynii
BGC0000046	0.66	Polyketide	depudecin	Alternaria brassicicola
BGC0002301	0.65	Polyketide	(P)-ustilaginoidin A	Aschersonia paraphysata
BGC0001286	0.64	Other	itaconic acid	Ustilago maydis
BGC0001124	0.64	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0002180	0.64	Polyketide	(+)-asperlin, (2Z,4Z,6E)-octa-2,4,6-trienoic acid	Aspergillus nidulans FGSC A4
BGC0002227	0.63	NRP	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0002177	0.63	Polyketide	ustilaginoidin N, ustilaginoidin O, ustilaginoidin M, ustilaginoidin A, ustilaginoidin F, ustilaginoidin E, ustilaginoidin D, ustilaginoidin G	Ustilaginoidea virens

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 31332:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (mal)
Non-colinear ordering:: Rdc5 + Rdc1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

Rdc1

PKS_AT (913..1209): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; Methylmalonyl-CoA: 58.3%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 95.8
Methoxymalonyl-CoA: 62.5
inactive: 58.9
Methylmalonyl-CoA: 48.6
Isobutyryl-CoA: 43.4
Benzoyl-CoA: 30.7
Propionyl-CoA: 25.6
2-Methylbutyryl-CoA: 23.9
Acetyl-CoA: 22.7
Ethylmalonyl-CoA: 21.9
CHC-CoA: 20.6
fatty_acid: 20.5
3-Methylbutyryl-CoA: 19.0
trans-1,2-CPDA: 17.1

Rdc5

PKS_AT (550..862): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; Methylmalonyl-CoA: 70.8%; 2-Methylbutyryl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 91.4
Methoxymalonyl-CoA: 79.3
Malonyl-CoA: 61.7
Ethylmalonyl-CoA: 60.3
Isobutyryl-CoA: 53.5
Benzoyl-CoA: 48.1
Propionyl-CoA: 30.6
2-Methylbutyryl-CoA: 27.8
CHC-CoA: 26.3
trans-1,2-CPDA: 25.5
3-Methylbutyryl-CoA: 17.9
fatty_acid: 16.8
inactive: 15.4
Acetyl-CoA: 7.0