BGC0000135: reveromycin A biosynthetic gene cluster from Streptomyces sp. SN-593
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Location: 1 - 104,853 nt. (total: 104,853 nt).
This entry is originally from NCBI GenBank AB568601.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000135
Short description reveromycin A biosynthetic gene cluster from Streptomyces sp. SN-593
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
AB568601.1
via
Compounds
  • reveromycin A
Species Streptomyces sp. SN-593 [taxonomy]
References
Chemical products information
reveromycin A Evidence:
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C36H52O11
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAK64627.1
 1 - 909 (-) putative amidohydrolase
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    • BAK64628.1
    		 954 - 1637 (-) hypothetical protein
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      • BAK64629.1
      		 1874 - 2899 (-) putative amidohydrolase
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        • BAK64630.1
        		 3134 - 3793 (+) putative transcriptional regulator
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          • BAK64631.1
          • revO
          		 4375 - 5676 (+) putative transporter
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            • BAK64632.1
            • revP
            		 5725 - 6399 (-) putative transcriptional regulator
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              • BAK64633.1
              • revQ
              		 6591 - 7424 (-) putative transcriptional regulator
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                • BAK64634.1
                • revR
                		 7941 - 8942 (-) putative 3-oxoacyl-ACP synthase
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                  • BAK64635.1
                  • revS
                  		 8942 - 10681 (-) putative CoA ligase
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                    • BAK64636.1
                    • revT
                    		 10719 - 12050 (-) putative CoA reductase carboxylase
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                      • BAK64637.1
                      • revB
                      		 12672 - 28304 (+) polyketide synthase
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                        • BAK64638.1
                        • revC
                        		 28332 - 39506 (+) polyketide synthase
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                          • BAK64639.1
                          • revE
                          		 39521 - 40624 (+) putative dehydrogenase
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                            • BAK64640.1
                            • revF
                            		 40693 - 42144 (+) putative aldehyde dehydrogenase
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                              • BAK64641.1
                              • revG
                              		 42227 - 43048 (+) dihydroxy ketone synthase
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                                • BAK64642.1
                                • revH
                                		 43118 - 44641 (-) putative FAD dependent oxidoreductase
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                                  • BAK64643.1
                                  • revI
                                  		 44684 - 45877 (-) putative monooxygenase
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                                    • BAK64644.1
                                    • revJ
                                    		 45944 - 46954 (-) spiroacetal synthase
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                                      • BAK64645.1
                                      • revK
                                      		 47347 - 48279 (+) putative malonyl transferase
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                                        • BAK64646.1
                                        • revL
                                        		 48311 - 49384 (+) hypothetical protein
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                                          • BAK64647.1
                                          • revM
                                          		 49561 - 50523 (+) putative quinone oxidoreductase
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                                            • BAK64648.1
                                            • revN
                                            		 50747 - 51664 (+) putative thioesterase
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                                              • BAK64649.1
                                              • revA
                                              		 52185 - 71039 (+) polyketide synthase
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                                                • BAK64650.1
                                                • revD
                                                		 71116 - 92208 (+) polyketide synthase
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                                                  • BAK64651.1
                                                  • revU
                                                  		 92596 - 95367 (+) putative transcriptional regulator
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                                                    • BAK64652.1
                                                    		 95517 - 96494 (-) hypothetical protein
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                                                      • BAK64653.1
                                                      		 96795 - 98486 (+) putative transporter
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                                                        • BAK64654.1
                                                        		 98486 - 99700 (+) putative transporter
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                                                          • BAK64655.1
                                                          		 99718 - 100890 (+) putative peptidase
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                                                            • BAK64656.1
                                                            		 100893 - 101957 (+) putative oxidoreductase
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                                                              • BAK64657.1
                                                              		 101954 - 102976 (+) putative dehydrogenase
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                                                                • BAK64658.1
                                                                		 102995 - 103888 (+) putative hydrolase
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                                                                  • BAK64659.1
                                                                  		 103885 - 104853 (+) hypothetical protein
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                                                                    Biosynthesis information
                                                                    Annotation changelog

                                                                    Entry version: 4

                                                                    Date
                                                                    Changes
                                                                    Submitters
                                                                    Reviewers
                                                                    2022-10-07
                                                                    Update chemical activity to schema version 2.11
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                    Entry version: 3

                                                                    Date
                                                                    Changes
                                                                    Submitters
                                                                    Reviewers
                                                                    2022-09-15
                                                                    Updated bioactivity data
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                    Entry version: 2

                                                                    Date
                                                                    Changes
                                                                    Submitters
                                                                    Reviewers
                                                                    2019-10-16
                                                                    Migrated from v1.4
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    2019-10-16
                                                                    Updated compound(s) information (NPAtlas curation)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                    Entry version: 1

                                                                    Date
                                                                    Changes
                                                                    Submitters
                                                                    Reviewers
                                                                    2015-06-12
                                                                    Submitted
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    Detailed domain annotation
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