BGC0000135 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000135 (Streptomyces sp. SN-593)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	104,853	reveromycin A	PKS	96%

BGC0000135 - Region 1 - T1PKS

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Location: 1 - 104,853 nt. (total: 104,853 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 104,854
Label		BGC0000135

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000135	0.93	Polyketide	reveromycin A	Streptomyces sp. SN-593
BGC0001925	0.35	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0001163	0.34	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001647	0.33	Polyketide	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18
BGC0000122	0.33	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0000041	0.32	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001137	0.31	Alkaloid	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0002084	0.31	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0002099	0.31	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0001283	0.31	Polyketide	arsono-polyketide	Streptomyces lividans 1326

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000135	0.98	Polyketide	reveromycin A	Streptomyces sp. SN-593
BGC0001925	0.68	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0001163	0.67	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001647	0.67	Polyketide	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18
BGC0000122	0.66	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0000041	0.65	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001137	0.65	Alkaloid	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0002084	0.65	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0002099	0.65	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0001283	0.65	Polyketide	arsono-polyketide	Streptomyces lividans 1326

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 104853:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - ccmal - Me-ccmal - ccmal) + (Me-ohmal - redmal - ohmal) + (Me-redmal - ohmal) + (Me-ccmal - ccmal - Me-ohmal - ccmal)
Non-colinear ordering:: revA + revB + revC + revD

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

revS

CAL_domain (43..477): pk

minowa: fatty_acid

Prediction, score:

fatty_acid: 14.9
NH2: 11.2
Acetyl-CoA: 1.0
shikimic_acid: 0.0
AHBA: -0.5

revB

PKS_AT (579..879): mmal

ATSignature: Methylmalonyl-CoA, Ethylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 79.2%; Ethylmalonyl-CoA: 79.2%; Malonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 174.6
Ethylmalonyl-CoA: 163.3
Methoxymalonyl-CoA: 147.8
2-Methylbutyryl-CoA: 100.9
CHC-CoA: 96.8
trans-1,2-CPDA: 95.4
Isobutyryl-CoA: 78.4
Propionyl-CoA: 75.3
Malonyl-CoA: 71.4
Benzoyl-CoA: 71.1
3-Methylbutyryl-CoA: 36.9
fatty_acid: 36.2
Acetyl-CoA: 22.5
inactive: 17.2

PKS_AT (2121..2395): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 211.6
inactive: 96.4
Methoxymalonyl-CoA: 59.7
Methylmalonyl-CoA: 50.3
Propionyl-CoA: 28.3
Isobutyryl-CoA: 25.3
Acetyl-CoA: 24.9
Benzoyl-CoA: 20.9
Ethylmalonyl-CoA: 19.9
fatty_acid: 14.9
2-Methylbutyryl-CoA: 14.1
CHC-CoA: 12.0
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (4181..4460): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 201.4
inactive: 90.5
Methoxymalonyl-CoA: 59.1
Methylmalonyl-CoA: 44.6
Isobutyryl-CoA: 27.0
Acetyl-CoA: 26.1
Propionyl-CoA: 24.7
Ethylmalonyl-CoA: 20.2
Benzoyl-CoA: 19.5
fatty_acid: 13.4
2-Methylbutyryl-CoA: 13.1
CHC-CoA: 9.8
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

revC

PKS_AT (602..894): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 213.5
Ethylmalonyl-CoA: 208.8
Methoxymalonyl-CoA: 165.5
2-Methylbutyryl-CoA: 133.3
Propionyl-CoA: 123.4
trans-1,2-CPDA: 122.6
Malonyl-CoA: 118.6
CHC-CoA: 106.1
Isobutyryl-CoA: 81.2
Acetyl-CoA: 71.5
Benzoyl-CoA: 65.6
inactive: 45.6
3-Methylbutyryl-CoA: 36.1
fatty_acid: 25.6

PKS_AT (2704..2982): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 218.1
inactive: 97.9
Methoxymalonyl-CoA: 69.7
Methylmalonyl-CoA: 53.8
Propionyl-CoA: 35.0
Isobutyryl-CoA: 28.2
Acetyl-CoA: 23.7
Benzoyl-CoA: 22.7
fatty_acid: 22.0
CHC-CoA: 20.6
Ethylmalonyl-CoA: 19.8
trans-1,2-CPDA: 17.7
2-Methylbutyryl-CoA: 9.5
3-Methylbutyryl-CoA: 0.0

revK

PKS_AT (11..275): pk

ATSignature: (unknown)

No matches above 50%

minowa: trans-1,2-CPDA

Prediction, score:

trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

revL

AMP-binding (91..307): X

nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GLQNRSSFGK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

revA

PKS_AT (546..858): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.6
Ethylmalonyl-CoA: 206.6
Methoxymalonyl-CoA: 163.5
2-Methylbutyryl-CoA: 150.5
Malonyl-CoA: 116.7
CHC-CoA: 115.3
trans-1,2-CPDA: 107.9
Propionyl-CoA: 107.2
Isobutyryl-CoA: 84.3
Benzoyl-CoA: 63.3
3-Methylbutyryl-CoA: 46.5
Acetyl-CoA: 45.6
fatty_acid: 40.1
inactive: 30.0

PKS_AT (1587..1866): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 201.7
inactive: 86.5
Methoxymalonyl-CoA: 60.0
Methylmalonyl-CoA: 44.6
Isobutyryl-CoA: 27.1
Acetyl-CoA: 26.0
Propionyl-CoA: 24.8
Benzoyl-CoA: 20.2
Ethylmalonyl-CoA: 18.6
fatty_acid: 13.7
2-Methylbutyryl-CoA: 13.6
CHC-CoA: 11.5
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (3338..3628): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 213.5
Ethylmalonyl-CoA: 206.9
Methoxymalonyl-CoA: 171.9
2-Methylbutyryl-CoA: 148.3
trans-1,2-CPDA: 127.7
Propionyl-CoA: 113.3
CHC-CoA: 111.3
Malonyl-CoA: 98.5
Isobutyryl-CoA: 76.6
Benzoyl-CoA: 70.9
Acetyl-CoA: 54.3
fatty_acid: 52.7
3-Methylbutyryl-CoA: 33.3
inactive: 29.7

PKS_AT (5034..5313): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 202.5
inactive: 86.8
Methoxymalonyl-CoA: 61.4
Methylmalonyl-CoA: 46.9
Isobutyryl-CoA: 29.5
Acetyl-CoA: 26.5
Propionyl-CoA: 26.2
Ethylmalonyl-CoA: 23.2
Benzoyl-CoA: 19.7
2-Methylbutyryl-CoA: 15.4
fatty_acid: 13.5
CHC-CoA: 12.2
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

revD

PKS_AT (577..867): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 214.1
Ethylmalonyl-CoA: 208.8
Methoxymalonyl-CoA: 171.7
2-Methylbutyryl-CoA: 148.2
trans-1,2-CPDA: 131.0
Propionyl-CoA: 114.2
CHC-CoA: 110.1
Malonyl-CoA: 100.2
Isobutyryl-CoA: 77.9
Benzoyl-CoA: 70.5
Acetyl-CoA: 54.0
fatty_acid: 52.7
3-Methylbutyryl-CoA: 32.7
inactive: 29.5

PKS_AT (2328..2605): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.8
inactive: 91.4
Methoxymalonyl-CoA: 58.9
Methylmalonyl-CoA: 48.5
Propionyl-CoA: 27.5
Acetyl-CoA: 25.9
Isobutyryl-CoA: 25.4
Benzoyl-CoA: 20.9
Ethylmalonyl-CoA: 19.8
2-Methylbutyryl-CoA: 14.9
fatty_acid: 14.0
CHC-CoA: 12.6
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (4055..4345): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 213.0
Ethylmalonyl-CoA: 205.5
Methoxymalonyl-CoA: 172.1
2-Methylbutyryl-CoA: 144.1
trans-1,2-CPDA: 130.6
Propionyl-CoA: 115.5
CHC-CoA: 108.2
Malonyl-CoA: 99.9
Isobutyryl-CoA: 72.9
Benzoyl-CoA: 68.4
Acetyl-CoA: 56.8
fatty_acid: 50.4
3-Methylbutyryl-CoA: 36.6
inactive: 32.5

PKS_AT (5564..5843): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 199.9
inactive: 88.6
Methoxymalonyl-CoA: 59.1
Methylmalonyl-CoA: 44.6
Isobutyryl-CoA: 29.0
Acetyl-CoA: 26.0
Propionyl-CoA: 23.6
Benzoyl-CoA: 19.3
Ethylmalonyl-CoA: 18.6
2-Methylbutyryl-CoA: 14.9
fatty_acid: 13.4
CHC-CoA: 12.3
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0