BGC0000136: rifamycin biosynthetic gene cluster from Amycolatopsis mediterranei S699
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Location: 1 - 109,528 nt. (total: 109,528 nt).
This entry is originally from NCBI GenBank AF040570.3.

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core biosynthetic genes
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NRPS/PKS domains
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General information about the BGC
MIBiG accession BGC0000136
Short description rifamycin biosynthetic gene cluster from Amycolatopsis mediterranei S699
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: AF040570.3
Compounds
  • rifamycin
Species Amycolatopsis mediterranei S699 [taxonomy]
References
Chemical products information
rifamycin
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C37H47N1O12
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAS07738.1
  • rplJ
 145 - 720 (+) RplJ
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  • AAS07739.1
  • rplL
 770 - 1153 (+) RplL
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  • AAS07740.1
 1559 - 2731 (+) putative ABC transporter ATP-binding protein
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  • AAS07741.1
 2770 - 3522 (+) putative ABC-transporter integral membrane protein
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  • AAS07742.1
 3527 - 4363 (+) putative ABC-transporter permease
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  • AAS07743.1
 4360 - 5685 (+) putative secreted protein
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  • AAS07744.1
 5682 - 6710 (+) putative lipoprotein
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  • AAS07745.1
 6707 - 7693 (+) putative lipoprotein
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  • AAS07746.1
 7690 - 8874 (+) putative secreted protein
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  • AAS07747.1
 8871 - 10043 (+) putative secreted protein
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  • AAS07748.1
 10043 - 11308 (+) putative secreted protein
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  • AAS07749.1
 11346 - 11921 (+) putative membrane protein
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  • AAS07750.1
 11944 - 12981 (+) putative integral membrane protein
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  • AAS07751.1
 12998 - 14020 (-) hypothetical protein
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  • AAC01706.1
 14281 - 15309 (+) unknown
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  • AAS07752.1
  • rifS
 14341 - 15309 (+) RifS
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  • AAC01707.1
  • rifT
 15306 - 16073 (+) RifT
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  • AAC01708.1
 16211 - 16477 (+) unknown
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  • AAS07753.1
 16250 - 16477 (+) hypothetical protein
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  • AAC01709.1
 16510 - 17700 (+) putative cytochrome P450-like protein
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  • AAC01710.1
  • rifA
 17741 - 31948 (+) RifA
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  • AAC01711.1
  • rifB
 31982 - 47164 (+) RifB
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  • AAC01712.2
  • rifC
 47174 - 52465 (+) RifC
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  • AAC01713.1
  • rifD
 52544 - 57730 (+) RifD
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  • AAC01714.1
  • rifE
 57778 - 68019 (+) RifE
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  • AAC01715.1
  • rifF
 68016 - 68798 (+) RifF
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  • AAC01716.1
 68818 - 69006 (+) hypothetical protein
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  • AAC01717.1
  • rifG
 69003 - 70058 (+) RifG
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  • AAC01718.1
  • rifH
 70055 - 71380 (+) RifH
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  • AAC01719.1
  • rifI
 71400 - 72191 (+) RifI
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  • AAC01720.1
  • rifK
 72331 - 73497 (+) RifK
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  • AAS07754.1
  • rifL
 73571 - 74647 (+) RifL
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  • AAC01721.1
  • rifM
 74662 - 75360 (+) RifM
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  • AAC01722.2
  • rifN
 75569 - 76276 (+) RifN
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  • AAC01723.1
  • rifO
 76343 - 77110 (+) RifO
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  • AAC01724.1
 77187 - 78119 (+) putative esterase
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  • AAC01725.1
  • rifP
 78416 - 79984 (+) RifP
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  • AAC01726.1
  • rifQ
 80000 - 80728 (+) RifQ
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  • AAC01727.1
 80735 - 81235 (-) hypothetical protein
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  • AAC01728.1
 81320 - 82531 (-) putative cytochrome P450 oxidoreductase
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  • AAC01729.1
 82562 - 83827 (-) putative cytochrome P450 monooxygenase
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  • AAC01730.1
 83901 - 85208 (-) putative dNTP-hexose dehydratase
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  • AAC01731.1
 85411 - 86556 (+) putative dNTP-hexose glycosyltransferase
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  • AAS07755.1
 86563 - 87207 (+) putative dNTP-hexose 3,5-epimerase
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  • AAC01732.1
 86587 - 87207 (+) dNTP-hexose 3,5 epimerase
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  • AAS07756.1
 87270 - 88562 (-) putative aminotransferase
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  • AAC01733.1
 87270 - 88568 (-) dNTP-hexose aminotransferase
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  • AAC01734.1
 88587 - 89579 (-) putative dNTP-hexose 3-ketoreductase
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  • AAC01735.3
 89646 - 90611 (+) putative flavin-dependent oxidoreductase
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  • AAG52987.1
 90638 - 91708 (+) putative alpha-chain alkanal monooxygenase
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  • AAG52988.1
 91789 - 93210 (+) putative 2,3-dehydratase
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  • AAG52989.1
 93305 - 94810 (-) putative 3-(3-hydroxylphenyl) propionate hydroxylase
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  • AAG52990.1
 94826 - 96037 (-) putative polyketide associated protein
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  • AAG52991.1
  • rifR
 96034 - 96813 (-) RifR
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  • AAC01737.2
 96833 - 98101 (-) putative cytochrome P450 monooxygenase
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  • AAC01738.1
 98368 - 99186 (+) C-27 O-methyltransferase
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  • AAS07757.1
 99201 - 99893 (+) putative transketolase A subunit
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  • AAC01739.2
 99890 - 100801 (+) putative transketolase B subunit
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  • AAC01740.2
 101062 - 102231 (-) putative cytochrome P450 monooxygenase
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  • AAS07762.1
  • rifJ
 102476 - 102967 (+) aminodehydroquinate dehydratase
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  • AAS07758.1
 103594 - 104808 (+) putative regulatory protein
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  • AAS07759.1
 104813 - 105298 (+) hypothetical protein
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  • AAS07760.1
  • rpoB
 105773 - 109276 (+) RpoB
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  • AAS07761.1
  • rpoC
 109375 - >109528 (+) RpoC
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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