BGC0000136: rifamycin biosynthetic gene cluster from Amycolatopsis mediterranei S699
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Location: 1 - 109,528 nt. (total: 109,528 nt).
This entry is originally from NCBI GenBank AF040570.3.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000136
Short description rifamycin biosynthetic gene cluster from Amycolatopsis mediterranei S699
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
AF040570.3
via
Compounds
  • rifamycin
Species Amycolatopsis mediterranei S699 [taxonomy]
References
Chemical products information
rifamycin Evidence:
Copy SMILES
C37H47N1O12
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAS07738.1
  • rplJ
 145 - 720 (+) RplJ
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    • AAS07739.1
    • rplL
    		 770 - 1153 (+) RplL
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      • AAS07740.1
      		 1559 - 2731 (+) putative ABC transporter ATP-binding protein
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        • AAS07741.1
        		 2770 - 3522 (+) putative ABC-transporter integral membrane protein
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          • AAS07742.1
          		 3527 - 4363 (+) putative ABC-transporter permease
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            • AAS07743.1
            		 4360 - 5685 (+) putative secreted protein
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              • AAS07744.1
              		 5682 - 6710 (+) putative lipoprotein
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                • AAS07745.1
                		 6707 - 7693 (+) putative lipoprotein
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                  • AAS07746.1
                  		 7690 - 8874 (+) putative secreted protein
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                    • AAS07747.1
                    		 8871 - 10043 (+) putative secreted protein
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                      • AAS07748.1
                      		 10043 - 11308 (+) putative secreted protein
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                        • AAS07749.1
                        		 11346 - 11921 (+) putative membrane protein
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                          • AAS07750.1
                          		 11944 - 12981 (+) putative integral membrane protein
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                            • AAS07751.1
                            		 12998 - 14020 (-) hypothetical protein
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                              • AAC01706.1
                              		 14281 - 15309 (+) unknown
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                                • AAS07752.1
                                • rifS
                                		 14341 - 15309 (+) RifS
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                                  • AAC01707.1
                                  • rifT
                                  		 15306 - 16073 (+) RifT
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                                    • AAC01708.1
                                    		 16211 - 16477 (+) unknown
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                                      • AAS07753.1
                                      		 16250 - 16477 (+) hypothetical protein
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                                        • AAC01709.1
                                        		 16510 - 17700 (+) putative cytochrome P450-like protein
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                                          • AAC01710.1
                                          • rifA
                                          		 17741 - 31948 (+) RifA
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                                            • AAC01711.1
                                            • rifB
                                            		 31982 - 47164 (+) RifB
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                                              • AAC01712.2
                                              • rifC
                                              		 47174 - 52465 (+) RifC
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                                                • AAC01713.1
                                                • rifD
                                                		 52544 - 57730 (+) RifD
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                                                  • AAC01714.1
                                                  • rifE
                                                  		 57778 - 68019 (+) RifE
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                                                    • AAC01715.1
                                                    • rifF
                                                    		 68016 - 68798 (+) RifF
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                                                      • AAC01716.1
                                                      		 68818 - 69006 (+) hypothetical protein
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                                                        • AAC01717.1
                                                        • rifG
                                                        		 69003 - 70058 (+) RifG
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                                                          • AAC01718.1
                                                          • rifH
                                                          		 70055 - 71380 (+) RifH
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                                                            • AAC01719.1
                                                            • rifI
                                                            		 71400 - 72191 (+) RifI
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                                                              • AAC01720.1
                                                              • rifK
                                                              		 72331 - 73497 (+) RifK
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                                                                • AAS07754.1
                                                                • rifL
                                                                		 73571 - 74647 (+) RifL
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                                                                  • AAC01721.1
                                                                  • rifM
                                                                  		 74662 - 75360 (+) RifM
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                                                                    • AAC01722.2
                                                                    • rifN
                                                                    		 75569 - 76276 (+) RifN
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                                                                      • AAC01723.1
                                                                      • rifO
                                                                      		 76343 - 77110 (+) RifO
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                                                                        • AAC01724.1
                                                                        		 77187 - 78119 (+) putative esterase
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                                                                          • AAC01725.1
                                                                          • rifP
                                                                          		 78416 - 79984 (+) RifP
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                                                                            • AAC01726.1
                                                                            • rifQ
                                                                            		 80000 - 80728 (+) RifQ
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                                                                              • AAC01727.1
                                                                              		 80735 - 81235 (-) hypothetical protein
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                                                                                • AAC01728.1
                                                                                		 81320 - 82531 (-) putative cytochrome P450 oxidoreductase
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                                                                                  • AAC01729.1
                                                                                  		 82562 - 83827 (-) putative cytochrome P450 monooxygenase
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                                                                                    • AAC01730.1
                                                                                    		 83901 - 85208 (-) putative dNTP-hexose dehydratase
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                                                                                      • AAC01731.1
                                                                                      		 85411 - 86556 (+) putative dNTP-hexose glycosyltransferase
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                                                                                        • AAS07755.1
                                                                                        		 86563 - 87207 (+) putative dNTP-hexose 3,5-epimerase
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                                                                                          • AAC01732.1
                                                                                          		 86587 - 87207 (+) dNTP-hexose 3,5 epimerase
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                                                                                            • AAS07756.1
                                                                                            		 87270 - 88562 (-) putative aminotransferase
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                                                                                              • AAC01733.1
                                                                                              		 87270 - 88568 (-) dNTP-hexose aminotransferase
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                                                                                                • AAC01734.1
                                                                                                		 88587 - 89579 (-) putative dNTP-hexose 3-ketoreductase
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                                                                                                  • AAC01735.3
                                                                                                  		 89646 - 90611 (+) putative flavin-dependent oxidoreductase
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                                                                                                    • AAG52987.1
                                                                                                    		 90638 - 91708 (+) putative alpha-chain alkanal monooxygenase
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                                                                                                      • AAG52988.1
                                                                                                      		 91789 - 93210 (+) putative 2,3-dehydratase
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                                                                                                        • AAG52989.1
                                                                                                        		 93305 - 94810 (-) putative 3-(3-hydroxylphenyl) propionate hydroxylase
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                                                                                                          • AAG52990.1
                                                                                                          		 94826 - 96037 (-) putative polyketide associated protein
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                                                                                                            • AAG52991.1
                                                                                                            • rifR
                                                                                                            		 96034 - 96813 (-) RifR
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                                                                                                              • AAC01737.2
                                                                                                              		 96833 - 98101 (-) putative cytochrome P450 monooxygenase
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                                                                                                                • AAC01738.1
                                                                                                                		 98368 - 99186 (+) C-27 O-methyltransferase
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                                                                                                                  • AAS07757.1
                                                                                                                  		 99201 - 99893 (+) putative transketolase A subunit
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                                                                                                                    • AAC01739.2
                                                                                                                    		 99890 - 100801 (+) putative transketolase B subunit
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                                                                                                                      • AAC01740.2
                                                                                                                      		 101062 - 102231 (-) putative cytochrome P450 monooxygenase
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                                                                                                                        • AAS07762.1
                                                                                                                        • rifJ
                                                                                                                        		 102476 - 102967 (+) aminodehydroquinate dehydratase
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                                                                                                                          • AAS07758.1
                                                                                                                          		 103594 - 104808 (+) putative regulatory protein
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                                                                                                                            • AAS07759.1
                                                                                                                            		 104813 - 105298 (+) hypothetical protein
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                                                                                                                              • AAS07760.1
                                                                                                                              • rpoB
                                                                                                                              		 105773 - 109276 (+) RpoB
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                                                                                                                                • AAS07761.1
                                                                                                                                • rpoC
                                                                                                                                		 109375 - >109528 (+) RpoC
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                                                                                                                                  Biosynthesis information
                                                                                                                                  Annotation changelog

                                                                                                                                  Entry version: 4

                                                                                                                                  Date
                                                                                                                                  Changes
                                                                                                                                  Submitters
                                                                                                                                  Reviewers
                                                                                                                                  2022-10-07
                                                                                                                                  Update chemical activity to schema version 2.11
                                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                  Entry version: 3

                                                                                                                                  Date
                                                                                                                                  Changes
                                                                                                                                  Submitters
                                                                                                                                  Reviewers
                                                                                                                                  2022-09-15
                                                                                                                                  Updated bioactivity data
                                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                  Entry version: 2

                                                                                                                                  Date
                                                                                                                                  Changes
                                                                                                                                  Submitters
                                                                                                                                  Reviewers
                                                                                                                                  2019-10-16
                                                                                                                                  Migrated from v1.4
                                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                  Entry version: 1

                                                                                                                                  Date
                                                                                                                                  Changes
                                                                                                                                  Submitters
                                                                                                                                  Reviewers
                                                                                                                                  2015-06-12
                                                                                                                                  Submitted
                                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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