Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000136.1:
Cluster 1Polyketide1109528

BGC0000136, rifamycin biosynthetic gene cluster from Amycolatopsis mediterranei. Locus 1. Partial MIBiG entry.

Chemical compounds

Compound: rifamycin
PubChem ID: 6324616
SMILES string: Copy to clipboard
Molecular formula: C37H47NO12
Average molecular mass: 697.778 Da

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide synthase subclass:
Type I

Gene cluster description

rifamycin (BGC0000136). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank AF040570. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

Literature references

1. August PR et al. (1998) Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699. Chem Biol 5(2):69-79.
2. Kim CG et al. (1998) 3-Amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics. J Biol Chem 273(11):6030-40.
3. Yu TW et al. (2001) Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699. J Biol Chem 276(16):12546-55. doi: 10.1074/jbc.M009667200. Epub 2001